Superior dry bonding of off-stoichiometry thiol-ene epoxy (OSTE(+)) polymers for heterogeneous material labs-on-chip

Farizah Saharil, Lamia El Fissi, Yitong Liu, Fredrik Calborg, Denis Vandormael, Laurent A. Francis, Wouter Van Der Wijngaart, Tommy Haraldsson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

We demonstrate biocompatible bonding to a multitude of LoC substrates using OSTE(+). a novel polymer formulation with a unique dual cure system developed specifically for microfluidic applications. OSTE(+) allows for soft lithography microstructuring. strong biocompatible dry bonding to almost any substrate during LoC manufacturing, while simultaneously mimicking the mechanical properties found in thermoplastic polymers, hence allowing for true prototyping of commercial LoC's. In this work, we describe the simple micropatteming process, curing mechanisms and show leak-free dry bonding to nine different substrate materials. Uniquely, strong bonding is achieved to C'OC. the thermoplastic of choice for microfluidics, which opens up the possibility of hybrid thermoplastic/OSTE(+) LoCs. In this work, we demonstrate bonding to nine different untreated substrates at 37CC and room temperature to demonstrate good bonding properties even at lower temperature. We also show the high resilience of the epoxy bond by immersing an aluminum substrate with a bonded OSTE(+) layer into boiling water while simultaneously subjecting the assembly to pressurized air.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1831-1833
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012
Externally publishedYes
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa
Duration: 28 Oct 20121 Nov 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CityOkinawa
Period28/10/121/11/12

Fingerprint

Sulfhydryl Compounds
Stoichiometry
Polymers
Thermoplastics
Substrates
Microfluidics
Aluminum
Boiling liquids
Lithography
Curing
Mechanical properties
Temperature
Water
Air

Keywords

  • Bonding
  • COC
  • Microfabrication
  • Microfluidics
  • Off-stoichiometiy thiol-ene
  • OSTE
  • Soft lithography

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Saharil, F., El Fissi, L., Liu, Y., Calborg, F., Vandormael, D., Francis, L. A., ... Haraldsson, T. (2012). Superior dry bonding of off-stoichiometry thiol-ene epoxy (OSTE(+)) polymers for heterogeneous material labs-on-chip. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1831-1833). Chemical and Biological Microsystems Society.

Superior dry bonding of off-stoichiometry thiol-ene epoxy (OSTE(+)) polymers for heterogeneous material labs-on-chip. / Saharil, Farizah; El Fissi, Lamia; Liu, Yitong; Calborg, Fredrik; Vandormael, Denis; Francis, Laurent A.; Van Der Wijngaart, Wouter; Haraldsson, Tommy.

Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. p. 1831-1833.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Saharil, F, El Fissi, L, Liu, Y, Calborg, F, Vandormael, D, Francis, LA, Van Der Wijngaart, W & Haraldsson, T 2012, Superior dry bonding of off-stoichiometry thiol-ene epoxy (OSTE(+)) polymers for heterogeneous material labs-on-chip. in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, pp. 1831-1833, 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Okinawa, 28/10/12.
Saharil F, El Fissi L, Liu Y, Calborg F, Vandormael D, Francis LA et al. Superior dry bonding of off-stoichiometry thiol-ene epoxy (OSTE(+)) polymers for heterogeneous material labs-on-chip. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society. 2012. p. 1831-1833
Saharil, Farizah ; El Fissi, Lamia ; Liu, Yitong ; Calborg, Fredrik ; Vandormael, Denis ; Francis, Laurent A. ; Van Der Wijngaart, Wouter ; Haraldsson, Tommy. / Superior dry bonding of off-stoichiometry thiol-ene epoxy (OSTE(+)) polymers for heterogeneous material labs-on-chip. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. pp. 1831-1833
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