Sudden Cardiac Death (SCD) - Risk stratification and prediction with molecular biomarkers

Junaida Osman, Shing Cheng Tan, Pey Yee Lee, Low Teck Yew, A. Rahman A. Jamal

Research output: Contribution to journalReview article

Abstract

Sudden cardiac death (SCD) is a sudden, unexpected death that is caused by the loss of heart function. While SCD affects many patients suffering from coronary artery diseases (CAD) and heart failure (HF), a considerable number of SCD events occur in asymptomatic individuals. Certain risk factors for SCD have been identified and incorporated in different clinical scores, however, risk stratification using such algorithms is only useful for health management rather than for early detection and prediction of future SCD events in high-risk individuals. In this review, we discuss different molecular biomarkers that are used for early detection of SCD. This includes genetic biomarkers, where the majority of them are genomic variants for genes that encode for ion channels. Meanwhile, protein biomarkers often denote proteins that play roles in pathophysiological processes that lead to CAD and HF, notably (i) atherosclerosis that involves oxidative stress and inflammation, as well as (ii) cardiac tissue damage that involves neurohormonal and hemodynamic regulation and myocardial stress. Finally, we outline existing challenges and future directions including the use of OMICS strategy for biomarker discovery and the multimarker panels.

Original languageEnglish
Article number39
JournalJournal of Biomedical Science
Volume26
Issue number1
DOIs
Publication statusPublished - 22 May 2019

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Sudden Cardiac Death
Biomarkers
Oxidative stress
Coronary Artery Disease
Hemodynamics
Heart Failure
Ion Channels
Proteins
Genes
Health
Tissue
Sudden Death
Atherosclerosis
Oxidative Stress
Inflammation

Keywords

  • biomarker
  • cardiovascular disease (CVD)
  • coronary artery disease (CAD)
  • coronary heart disease (CHD)
  • heart failure (HF)
  • sudden cardiac death (SCD)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Sudden Cardiac Death (SCD) - Risk stratification and prediction with molecular biomarkers. / Osman, Junaida; Tan, Shing Cheng; Lee, Pey Yee; Teck Yew, Low; A. Jamal, A. Rahman.

In: Journal of Biomedical Science, Vol. 26, No. 1, 39, 22.05.2019.

Research output: Contribution to journalReview article

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