Successful treatment of acute kidney injury secondary to haeme nephropathy in paroxysmal nocturnal haemoglobinuria with alkaline diuresis

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Abstract

Paroxysmal nocturnal haemoglobinuria (PNH) also known as 'Marchiafava Micheli syn-drome' is a rare condition which can lead to both acute and chronic forms of renal failure through renal tubular haemosiderin deposition. A 45-year-old lady with underlying PNH, pre-sented with complaints of fever, productive cough followed by dark coloured urine. Investiga-tions revealed pancytopenia with a markedly raised creatinine from her baseline (from 65 mmol/L to 385 mmol/L) consistent with acute kidney injury (AKI). Renal biopsy con-firmed the diagnosis of haeme nephropathy. The renal impairment improved rapidly and nor-malised over a period of 5 days with alkaline diuresis (AD). The patient did not require hae-modialysis unlike most other reported cases of AKI secondary to haeme nephropathy in PNH. This is the second reported case of AKI in PNH which was successfully treated with AD alone emphasizing the role of AD as a promising therapeutic strategy in this condition.

Original languageEnglish
Pages (from-to)198-203
Number of pages6
JournalEXCLI Journal
Volume11
Publication statusPublished - 2012

Fingerprint

hemoglobinuria
Paroxysmal Hemoglobinuria
diuresis
Diuresis
heme
kidney diseases
Heme
Acute Kidney Injury
kidneys
Kidney
Hemosiderin
Pancytopenia
Therapeutics
Cough
hemosiderin
Chronic Kidney Failure
Creatinine
Fever
cough
Urine

Keywords

  • Alkaline diuresis
  • Paroxysmal nocturnal haemoglobinuria

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Animal Science and Zoology

Cite this

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title = "Successful treatment of acute kidney injury secondary to haeme nephropathy in paroxysmal nocturnal haemoglobinuria with alkaline diuresis",
abstract = "Paroxysmal nocturnal haemoglobinuria (PNH) also known as 'Marchiafava Micheli syn-drome' is a rare condition which can lead to both acute and chronic forms of renal failure through renal tubular haemosiderin deposition. A 45-year-old lady with underlying PNH, pre-sented with complaints of fever, productive cough followed by dark coloured urine. Investiga-tions revealed pancytopenia with a markedly raised creatinine from her baseline (from 65 mmol/L to 385 mmol/L) consistent with acute kidney injury (AKI). Renal biopsy con-firmed the diagnosis of haeme nephropathy. The renal impairment improved rapidly and nor-malised over a period of 5 days with alkaline diuresis (AD). The patient did not require hae-modialysis unlike most other reported cases of AKI secondary to haeme nephropathy in PNH. This is the second reported case of AKI in PNH which was successfully treated with AD alone emphasizing the role of AD as a promising therapeutic strategy in this condition.",
keywords = "Alkaline diuresis, Paroxysmal nocturnal haemoglobinuria",
author = "Sakthiswary Rajalingham and Srijit Das and {S. Abdul Wahid}, {S Fadilah}",
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journal = "EXCLI Journal",
issn = "1611-2156",
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T1 - Successful treatment of acute kidney injury secondary to haeme nephropathy in paroxysmal nocturnal haemoglobinuria with alkaline diuresis

AU - Rajalingham, Sakthiswary

AU - Das, Srijit

AU - S. Abdul Wahid, S Fadilah

PY - 2012

Y1 - 2012

N2 - Paroxysmal nocturnal haemoglobinuria (PNH) also known as 'Marchiafava Micheli syn-drome' is a rare condition which can lead to both acute and chronic forms of renal failure through renal tubular haemosiderin deposition. A 45-year-old lady with underlying PNH, pre-sented with complaints of fever, productive cough followed by dark coloured urine. Investiga-tions revealed pancytopenia with a markedly raised creatinine from her baseline (from 65 mmol/L to 385 mmol/L) consistent with acute kidney injury (AKI). Renal biopsy con-firmed the diagnosis of haeme nephropathy. The renal impairment improved rapidly and nor-malised over a period of 5 days with alkaline diuresis (AD). The patient did not require hae-modialysis unlike most other reported cases of AKI secondary to haeme nephropathy in PNH. This is the second reported case of AKI in PNH which was successfully treated with AD alone emphasizing the role of AD as a promising therapeutic strategy in this condition.

AB - Paroxysmal nocturnal haemoglobinuria (PNH) also known as 'Marchiafava Micheli syn-drome' is a rare condition which can lead to both acute and chronic forms of renal failure through renal tubular haemosiderin deposition. A 45-year-old lady with underlying PNH, pre-sented with complaints of fever, productive cough followed by dark coloured urine. Investiga-tions revealed pancytopenia with a markedly raised creatinine from her baseline (from 65 mmol/L to 385 mmol/L) consistent with acute kidney injury (AKI). Renal biopsy con-firmed the diagnosis of haeme nephropathy. The renal impairment improved rapidly and nor-malised over a period of 5 days with alkaline diuresis (AD). The patient did not require hae-modialysis unlike most other reported cases of AKI secondary to haeme nephropathy in PNH. This is the second reported case of AKI in PNH which was successfully treated with AD alone emphasizing the role of AD as a promising therapeutic strategy in this condition.

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