Successful clot lysis using low dose of streptokinase in 22 neonates with aortic thromboses

Cheah Fook Choe, N. Y. Boo, Rohana Jaafar, S. C. Yong

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To determine whether intravenous infusion of low dose of streptokinase was effective in lysing umbilical arterial catheter (UAC)-associated aortic thrombi. Method: A prospective cohort study of 31 consecutive newborn infants with UAC-associated aortic thrombi which were detected by abdominal ultrasonography after removal of UAC. Twenty-two infants were treated with intravenous infusion of low dose (1000 U/h) streptokinase, while nine others were not treated due to various contra-indications. Thrombolysis occurred after a mean interval of 2.2 days (standard deviation (SD) = 1.8) in the treated infants. In the untreated infants, spontaneous thrombolysis occurred significantly later, after a mean interval of 16.9 days (SD = 14.7) (95% confidence intervals of difference between mean intervals - 26.0, - 3.4;P = 0.02). Only one treated infant developed mild bleeding directly attributed to streptokinase therapy. Conclusion: Low dose streptokinase infusion was effective and safe in thrombolysing UAC-associated aortic thrombi.

Original languageEnglish
Pages (from-to)479-482
Number of pages4
JournalJournal of Paediatrics and Child Health
Volume37
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint

Umbilicus
Streptokinase
Thrombosis
Catheters
Newborn Infant
Intravenous Infusions
Ultrasonography
Cohort Studies
Prospective Studies
Confidence Intervals
Hemorrhage
Therapeutics

Keywords

  • Abdominal ultrasonography
  • Aortic thrombi
  • Streptokinase
  • Thrombolysis
  • Umbilical arterial catheterization

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Successful clot lysis using low dose of streptokinase in 22 neonates with aortic thromboses. / Fook Choe, Cheah; Boo, N. Y.; Jaafar, Rohana; Yong, S. C.

In: Journal of Paediatrics and Child Health, Vol. 37, No. 5, 2001, p. 479-482.

Research output: Contribution to journalArticle

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N2 - Objective: To determine whether intravenous infusion of low dose of streptokinase was effective in lysing umbilical arterial catheter (UAC)-associated aortic thrombi. Method: A prospective cohort study of 31 consecutive newborn infants with UAC-associated aortic thrombi which were detected by abdominal ultrasonography after removal of UAC. Twenty-two infants were treated with intravenous infusion of low dose (1000 U/h) streptokinase, while nine others were not treated due to various contra-indications. Thrombolysis occurred after a mean interval of 2.2 days (standard deviation (SD) = 1.8) in the treated infants. In the untreated infants, spontaneous thrombolysis occurred significantly later, after a mean interval of 16.9 days (SD = 14.7) (95% confidence intervals of difference between mean intervals - 26.0, - 3.4;P = 0.02). Only one treated infant developed mild bleeding directly attributed to streptokinase therapy. Conclusion: Low dose streptokinase infusion was effective and safe in thrombolysing UAC-associated aortic thrombi.

AB - Objective: To determine whether intravenous infusion of low dose of streptokinase was effective in lysing umbilical arterial catheter (UAC)-associated aortic thrombi. Method: A prospective cohort study of 31 consecutive newborn infants with UAC-associated aortic thrombi which were detected by abdominal ultrasonography after removal of UAC. Twenty-two infants were treated with intravenous infusion of low dose (1000 U/h) streptokinase, while nine others were not treated due to various contra-indications. Thrombolysis occurred after a mean interval of 2.2 days (standard deviation (SD) = 1.8) in the treated infants. In the untreated infants, spontaneous thrombolysis occurred significantly later, after a mean interval of 16.9 days (SD = 14.7) (95% confidence intervals of difference between mean intervals - 26.0, - 3.4;P = 0.02). Only one treated infant developed mild bleeding directly attributed to streptokinase therapy. Conclusion: Low dose streptokinase infusion was effective and safe in thrombolysing UAC-associated aortic thrombi.

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