Subclinical memory dysfunction in Malaysian systemic lupus erythematosus patients

Association with clinical characteristics and disease activity - A pilot study

Mohd Shahrir Mohamed Said, Saiful S. Bin Shudim, Khairiyah Mohamad, Syahrul Sazliyana Shaharir, Norella K C Tong, Raymond Azman Ali

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim of the work: This work aimed to determine the frequency of subclinical memory dysfunction in a group of Malaysian systemic lupus erythematosus (SLE) patients and to study its relation to clinical characteristics, laboratory investigations and disease activity. Patients and methods: Fifteen SLE patients attending the Universiti Kebangsaan Malaysia Medical Centre (UKMMC) and not known to have neuropsychiatric lupus were recruited. These patients were assessed using the Wechsler Memory Scale. Disease activity was assessed using the SLE disease activity index 2000 (SLEDAI-2K). Results: The median age of the patients was 28. years (25-37. years) and they were 14 females and one male. Their median disease duration was 9.3. years (4.8-10. years). Their median SLEDAI-2K was 4 (0-6). Memory dysfunction was identified in 7/15 (46.7%) SLE patients and was significantly associated with lower serum thyroxine levels (median 12.27; 11.8-13.3. μg/dl) (p = 0.027) compared to those without memory impairment (15.48; 14.39-16.56. μg/dl). Auditory memory impairment was associated with the education level as the auditory memory index was significantly lower in patients with secondary education (n = 7, median 88; 86.5-91.5) compared to those who received tertiary education (n = 8, median 103; 97.5-119.5) (p = 0.025) while visual memory was influenced by disease duration (p = 0.016). There was no association between overall memory dysfunction and disease duration, number of relapses, clinical manifestations and SLEDAI-2K scores. Conclusion: There is a high frequency of subclinical memory dysfunction among SLE patients. A remarkable association is present with lower thyroxine. Auditory memory impairment is related to the level of education and visual memory to disease duration.

Original languageEnglish
JournalEgyptian Rheumatologist
DOIs
Publication statusAccepted/In press - 30 Nov 2015

Fingerprint

Systemic Lupus Erythematosus
Education
Thyroxine
Wechsler Scales
Malaysia
Recurrence

Keywords

  • Hypothyroidism
  • Memory dysfunction
  • Systemic lupus erythematosus
  • Wechsler Memory Scale-IV Ed

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{f5f94777bb494f75b41e221d7ee93d3a,
title = "Subclinical memory dysfunction in Malaysian systemic lupus erythematosus patients: Association with clinical characteristics and disease activity - A pilot study",
abstract = "Aim of the work: This work aimed to determine the frequency of subclinical memory dysfunction in a group of Malaysian systemic lupus erythematosus (SLE) patients and to study its relation to clinical characteristics, laboratory investigations and disease activity. Patients and methods: Fifteen SLE patients attending the Universiti Kebangsaan Malaysia Medical Centre (UKMMC) and not known to have neuropsychiatric lupus were recruited. These patients were assessed using the Wechsler Memory Scale. Disease activity was assessed using the SLE disease activity index 2000 (SLEDAI-2K). Results: The median age of the patients was 28. years (25-37. years) and they were 14 females and one male. Their median disease duration was 9.3. years (4.8-10. years). Their median SLEDAI-2K was 4 (0-6). Memory dysfunction was identified in 7/15 (46.7{\%}) SLE patients and was significantly associated with lower serum thyroxine levels (median 12.27; 11.8-13.3. μg/dl) (p = 0.027) compared to those without memory impairment (15.48; 14.39-16.56. μg/dl). Auditory memory impairment was associated with the education level as the auditory memory index was significantly lower in patients with secondary education (n = 7, median 88; 86.5-91.5) compared to those who received tertiary education (n = 8, median 103; 97.5-119.5) (p = 0.025) while visual memory was influenced by disease duration (p = 0.016). There was no association between overall memory dysfunction and disease duration, number of relapses, clinical manifestations and SLEDAI-2K scores. Conclusion: There is a high frequency of subclinical memory dysfunction among SLE patients. A remarkable association is present with lower thyroxine. Auditory memory impairment is related to the level of education and visual memory to disease duration.",
keywords = "Hypothyroidism, Memory dysfunction, Systemic lupus erythematosus, Wechsler Memory Scale-IV Ed",
author = "{Mohamed Said}, {Mohd Shahrir} and {Bin Shudim}, {Saiful S.} and Khairiyah Mohamad and Shaharir, {Syahrul Sazliyana} and Tong, {Norella K C} and Ali, {Raymond Azman}",
year = "2015",
month = "11",
day = "30",
doi = "10.1016/j.ejr.2015.12.001",
language = "English",
journal = "Egyptian Rheumatologist",
issn = "1110-1164",
publisher = "The Egyptian Society for Joint Diseases and Arthritis",

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T1 - Subclinical memory dysfunction in Malaysian systemic lupus erythematosus patients

T2 - Association with clinical characteristics and disease activity - A pilot study

AU - Mohamed Said, Mohd Shahrir

AU - Bin Shudim, Saiful S.

AU - Mohamad, Khairiyah

AU - Shaharir, Syahrul Sazliyana

AU - Tong, Norella K C

AU - Ali, Raymond Azman

PY - 2015/11/30

Y1 - 2015/11/30

N2 - Aim of the work: This work aimed to determine the frequency of subclinical memory dysfunction in a group of Malaysian systemic lupus erythematosus (SLE) patients and to study its relation to clinical characteristics, laboratory investigations and disease activity. Patients and methods: Fifteen SLE patients attending the Universiti Kebangsaan Malaysia Medical Centre (UKMMC) and not known to have neuropsychiatric lupus were recruited. These patients were assessed using the Wechsler Memory Scale. Disease activity was assessed using the SLE disease activity index 2000 (SLEDAI-2K). Results: The median age of the patients was 28. years (25-37. years) and they were 14 females and one male. Their median disease duration was 9.3. years (4.8-10. years). Their median SLEDAI-2K was 4 (0-6). Memory dysfunction was identified in 7/15 (46.7%) SLE patients and was significantly associated with lower serum thyroxine levels (median 12.27; 11.8-13.3. μg/dl) (p = 0.027) compared to those without memory impairment (15.48; 14.39-16.56. μg/dl). Auditory memory impairment was associated with the education level as the auditory memory index was significantly lower in patients with secondary education (n = 7, median 88; 86.5-91.5) compared to those who received tertiary education (n = 8, median 103; 97.5-119.5) (p = 0.025) while visual memory was influenced by disease duration (p = 0.016). There was no association between overall memory dysfunction and disease duration, number of relapses, clinical manifestations and SLEDAI-2K scores. Conclusion: There is a high frequency of subclinical memory dysfunction among SLE patients. A remarkable association is present with lower thyroxine. Auditory memory impairment is related to the level of education and visual memory to disease duration.

AB - Aim of the work: This work aimed to determine the frequency of subclinical memory dysfunction in a group of Malaysian systemic lupus erythematosus (SLE) patients and to study its relation to clinical characteristics, laboratory investigations and disease activity. Patients and methods: Fifteen SLE patients attending the Universiti Kebangsaan Malaysia Medical Centre (UKMMC) and not known to have neuropsychiatric lupus were recruited. These patients were assessed using the Wechsler Memory Scale. Disease activity was assessed using the SLE disease activity index 2000 (SLEDAI-2K). Results: The median age of the patients was 28. years (25-37. years) and they were 14 females and one male. Their median disease duration was 9.3. years (4.8-10. years). Their median SLEDAI-2K was 4 (0-6). Memory dysfunction was identified in 7/15 (46.7%) SLE patients and was significantly associated with lower serum thyroxine levels (median 12.27; 11.8-13.3. μg/dl) (p = 0.027) compared to those without memory impairment (15.48; 14.39-16.56. μg/dl). Auditory memory impairment was associated with the education level as the auditory memory index was significantly lower in patients with secondary education (n = 7, median 88; 86.5-91.5) compared to those who received tertiary education (n = 8, median 103; 97.5-119.5) (p = 0.025) while visual memory was influenced by disease duration (p = 0.016). There was no association between overall memory dysfunction and disease duration, number of relapses, clinical manifestations and SLEDAI-2K scores. Conclusion: There is a high frequency of subclinical memory dysfunction among SLE patients. A remarkable association is present with lower thyroxine. Auditory memory impairment is related to the level of education and visual memory to disease duration.

KW - Hypothyroidism

KW - Memory dysfunction

KW - Systemic lupus erythematosus

KW - Wechsler Memory Scale-IV Ed

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