Subclinical hypothyroidism among patients with depressive disorders

Siti Yazmin Zahari Sham, Nor Aini Umar, Zarida Hambali, Rosdinom Razali, Mohd Rizal Abdul Manaf

Research output: Contribution to journalArticle

Abstract

Subclinical hypothyroidism (SHT) is a biochemical diagnosis, defined as an elevated Thyroid Stimulating Hormone (TSH) with normal free thyroxine (FT4). It affects 4-10% of the adult population and is more prevalent in elderly women. Its commonest cause is autoimmune thyroiditis, detected by anti-thyroid peroxidase antibody (TPO-Ab). About 2-5% of SHT patients progress to overt hypothyroidism annually. The SHT prevalence among depressed patients ranges between 3% and 17%. This study aimed to determine the prevalence of SHT and TPO-Ab positivity among patients diagnosed with depressive disorders. It was a cross-sectional study carried out in the Universiti Kebangsaan Malaysia Medical Centre over a 12 months period. Serum TSH, FT4 and TPO-Ab were measured. Results showed that 82% of depressed patients were euthyroid, 4% had SHT, 11% had subclinical hyperthyroidism and 2% had discordant thyroid function. TPO-Ab positivity among the subjects was 7%, one of whom had SHT. In conclusion, the prevalence of SHT and TPO-Ab positivity in the study population, at 4% and 7%, respectively, were comparable to previous findings.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalMalaysian Journal of Medicine and Health Sciences
Volume10
Issue number2
Publication statusPublished - 1 Jun 2014

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Depressive Disorder
Hypothyroidism
Iodide Peroxidase
Antibodies
Thyrotropin
Autoimmune Thyroiditis
Malaysia
Hyperthyroidism
Thyroxine
Population
Thyroid Gland
Cross-Sectional Studies
Serum

Keywords

  • Anti-thyroid peroxidase antibody
  • Depressed patients
  • Prevalence
  • Subclinical hypothyroid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Subclinical hypothyroidism among patients with depressive disorders. / Sham, Siti Yazmin Zahari; Umar, Nor Aini; Hambali, Zarida; Razali, Rosdinom; Abdul Manaf, Mohd Rizal.

In: Malaysian Journal of Medicine and Health Sciences, Vol. 10, No. 2, 01.06.2014, p. 71-78.

Research output: Contribution to journalArticle

Sham, Siti Yazmin Zahari ; Umar, Nor Aini ; Hambali, Zarida ; Razali, Rosdinom ; Abdul Manaf, Mohd Rizal. / Subclinical hypothyroidism among patients with depressive disorders. In: Malaysian Journal of Medicine and Health Sciences. 2014 ; Vol. 10, No. 2. pp. 71-78.
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