Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors

Narisa S ulaiman Sahari, Syahrul Sazliyana Shaharir, Mohd R edzuan Ismail, Sakthiswary Rajalingham, Mohd Shahrir Mohamed Said

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVE: To determine the associated factors of subclinical atherosclerosis measured with carotid intima media thickness (CIMT) among rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors.

METHODS: Forty RA patients with matched age and gender healthy controls were recruited. Carotid ultrasound was performed to all subjects. CIMT was considered to be abnormally thickened if it was more than the 75th percentile matched for age and sex reference values. Univariate and multivariate analyses were performed to determine the association between the sociodemographics and disease characteristics of RA with thickened CIMT.

RESULTS: Abnormally thickened CIMT were observed in 11 RA patients (27.5%) and in 4 control subjects (10%), p = 0.04. It was highly prevalent among RA patients with active disease (54.5% vs 17.2%), p = 0.02. Patients with thickened CIMT also tend to have erosive disease, p = 0.06. Seropositive rheumatoid factor (RF) patients also had significantly higher CIMT values as compared with sero-negative patients, p = 0.03. Multivariable logistic regression analysis revealed that active disease was independently associated with thickened CIMT.

CONCLUSIONS: RA patients are at risk for subclinical atherosclerosis despite absence of traditional CV risk co morbidities and active disease was the independent factor associated with it.

Original languageEnglish
Pages (from-to)920-925
Number of pages6
JournalModern rheumatology / the Japan Rheumatism Association
Volume24
Issue number6
DOIs
Publication statusPublished - 1 Nov 2014

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Carotid Intima-Media Thickness
Rheumatoid Arthritis
Atherosclerosis
Rheumatoid Factor
Reference Values
Multivariate Analysis
Logistic Models
Regression Analysis
Morbidity

Keywords

  • Atherosclerosis
  • Carotid intima media thickness
  • Disease activity
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Subclinical atherosclerosis among rheumatoid arthritis patients without overt cardiovascular risk factors",
abstract = "OBJECTIVE: To determine the associated factors of subclinical atherosclerosis measured with carotid intima media thickness (CIMT) among rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors.METHODS: Forty RA patients with matched age and gender healthy controls were recruited. Carotid ultrasound was performed to all subjects. CIMT was considered to be abnormally thickened if it was more than the 75th percentile matched for age and sex reference values. Univariate and multivariate analyses were performed to determine the association between the sociodemographics and disease characteristics of RA with thickened CIMT.RESULTS: Abnormally thickened CIMT were observed in 11 RA patients (27.5{\%}) and in 4 control subjects (10{\%}), p = 0.04. It was highly prevalent among RA patients with active disease (54.5{\%} vs 17.2{\%}), p = 0.02. Patients with thickened CIMT also tend to have erosive disease, p = 0.06. Seropositive rheumatoid factor (RF) patients also had significantly higher CIMT values as compared with sero-negative patients, p = 0.03. Multivariable logistic regression analysis revealed that active disease was independently associated with thickened CIMT.CONCLUSIONS: RA patients are at risk for subclinical atherosclerosis despite absence of traditional CV risk co morbidities and active disease was the independent factor associated with it.",
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author = "Sahari, {Narisa S ulaiman} and Shaharir, {Syahrul Sazliyana} and Ismail, {Mohd R edzuan} and Sakthiswary Rajalingham and {Mohamed Said}, {Mohd Shahrir}",
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AU - Sahari, Narisa S ulaiman

AU - Shaharir, Syahrul Sazliyana

AU - Ismail, Mohd R edzuan

AU - Rajalingham, Sakthiswary

AU - Mohamed Said, Mohd Shahrir

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N2 - OBJECTIVE: To determine the associated factors of subclinical atherosclerosis measured with carotid intima media thickness (CIMT) among rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors.METHODS: Forty RA patients with matched age and gender healthy controls were recruited. Carotid ultrasound was performed to all subjects. CIMT was considered to be abnormally thickened if it was more than the 75th percentile matched for age and sex reference values. Univariate and multivariate analyses were performed to determine the association between the sociodemographics and disease characteristics of RA with thickened CIMT.RESULTS: Abnormally thickened CIMT were observed in 11 RA patients (27.5%) and in 4 control subjects (10%), p = 0.04. It was highly prevalent among RA patients with active disease (54.5% vs 17.2%), p = 0.02. Patients with thickened CIMT also tend to have erosive disease, p = 0.06. Seropositive rheumatoid factor (RF) patients also had significantly higher CIMT values as compared with sero-negative patients, p = 0.03. Multivariable logistic regression analysis revealed that active disease was independently associated with thickened CIMT.CONCLUSIONS: RA patients are at risk for subclinical atherosclerosis despite absence of traditional CV risk co morbidities and active disease was the independent factor associated with it.

AB - OBJECTIVE: To determine the associated factors of subclinical atherosclerosis measured with carotid intima media thickness (CIMT) among rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors.METHODS: Forty RA patients with matched age and gender healthy controls were recruited. Carotid ultrasound was performed to all subjects. CIMT was considered to be abnormally thickened if it was more than the 75th percentile matched for age and sex reference values. Univariate and multivariate analyses were performed to determine the association between the sociodemographics and disease characteristics of RA with thickened CIMT.RESULTS: Abnormally thickened CIMT were observed in 11 RA patients (27.5%) and in 4 control subjects (10%), p = 0.04. It was highly prevalent among RA patients with active disease (54.5% vs 17.2%), p = 0.02. Patients with thickened CIMT also tend to have erosive disease, p = 0.06. Seropositive rheumatoid factor (RF) patients also had significantly higher CIMT values as compared with sero-negative patients, p = 0.03. Multivariable logistic regression analysis revealed that active disease was independently associated with thickened CIMT.CONCLUSIONS: RA patients are at risk for subclinical atherosclerosis despite absence of traditional CV risk co morbidities and active disease was the independent factor associated with it.

KW - Atherosclerosis

KW - Carotid intima media thickness

KW - Disease activity

KW - Rheumatoid arthritis

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