Subacute and subchronic toxicity studies of palm vitamin E in mice

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Palm oil is a rich source of vitamin E, especially the tocotrienols. It had been shown in previous studies to be effective in preventing and treating experimentally induced osteoporosis in laboratory rats. The objective of this study was to determine the subacute and subchronic toxic effects of palm vitamin E extract on mice. This was part of an ongoing effort to determine the potential for use of palm vitamin E as an anti-osteoporotic agent. The doses used in this study were 200, 500 and 1000 mg kg<sup>-1</sup>. Treatment period was 14 days for the Subacute Toxicity Study and 42 days for the Subchronic Toxicity Study. The parameters measured were Bleeding Time, Clotting Time, serum aspartate aminotransferase, serum creatinine as well as liver and kidney weights. The results showed that the Bleeding and Clotting Times were significantly prolonged in the 500 and 1000 mg kg<sup>-1</sup> groups in both the Subacute and Subchronic Toxicity Studies. Serum creatinine was raised in the 500 and 1000 mg kg<sup>-1</sup> group for the Subchronic Toxicity Study. Kidney weights were increased in the 200 and 500 mg kg<sup>-1</sup> groups for the Subacute Toxicity Study and in the 1000 mg kg<sup>-1</sup> group for the Subchronic Toxicity Study. No changes in serum aspartate aminotransferase levels or in liver weights were seen in both the Subacute and Subchronic Toxicity Studies. In conclusion, large doses of palm vitamin E in animals well above the effective dose used to prevent and treat osteoporosis may cause bleeding tendency and renal impairment but there was no liver toxicity.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalJournal of Pharmacology and Toxicology
Volume6
Issue number2
DOIs
Publication statusPublished - 2011

Fingerprint

Vitamin E
Bleeding Time
Aspartate Aminotransferases
Serum
Kidney
Weights and Measures
Osteoporosis
Liver
Creatinine
Tocotrienols
Poisons
Hemorrhage

Keywords

  • Mice
  • Palm vitamin E
  • Subacute
  • Subchronic
  • Toxicity studies

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{c9b896e623b34612ab0fb9eaeb89dd27,
title = "Subacute and subchronic toxicity studies of palm vitamin E in mice",
abstract = "Palm oil is a rich source of vitamin E, especially the tocotrienols. It had been shown in previous studies to be effective in preventing and treating experimentally induced osteoporosis in laboratory rats. The objective of this study was to determine the subacute and subchronic toxic effects of palm vitamin E extract on mice. This was part of an ongoing effort to determine the potential for use of palm vitamin E as an anti-osteoporotic agent. The doses used in this study were 200, 500 and 1000 mg kg-1. Treatment period was 14 days for the Subacute Toxicity Study and 42 days for the Subchronic Toxicity Study. The parameters measured were Bleeding Time, Clotting Time, serum aspartate aminotransferase, serum creatinine as well as liver and kidney weights. The results showed that the Bleeding and Clotting Times were significantly prolonged in the 500 and 1000 mg kg-1 groups in both the Subacute and Subchronic Toxicity Studies. Serum creatinine was raised in the 500 and 1000 mg kg-1 group for the Subchronic Toxicity Study. Kidney weights were increased in the 200 and 500 mg kg-1 groups for the Subacute Toxicity Study and in the 1000 mg kg-1 group for the Subchronic Toxicity Study. No changes in serum aspartate aminotransferase levels or in liver weights were seen in both the Subacute and Subchronic Toxicity Studies. In conclusion, large doses of palm vitamin E in animals well above the effective dose used to prevent and treat osteoporosis may cause bleeding tendency and renal impairment but there was no liver toxicity.",
keywords = "Mice, Palm vitamin E, Subacute, Subchronic, Toxicity studies",
author = "Soelaiman, {Ima Nirwana} and Y. Nurshazwani and Shuid, {Ahmad Nazrun} and Norliza Muhammad and Norazlina Mohamed",
year = "2011",
doi = "10.3923/jpt.2011.166.173",
language = "English",
volume = "6",
pages = "166--173",
journal = "Journal of Pharmacology and Toxicology",
issn = "1816-496X",
publisher = "Academic Journals Inc.",
number = "2",

}

TY - JOUR

T1 - Subacute and subchronic toxicity studies of palm vitamin E in mice

AU - Soelaiman, Ima Nirwana

AU - Nurshazwani, Y.

AU - Shuid, Ahmad Nazrun

AU - Muhammad, Norliza

AU - Mohamed, Norazlina

PY - 2011

Y1 - 2011

N2 - Palm oil is a rich source of vitamin E, especially the tocotrienols. It had been shown in previous studies to be effective in preventing and treating experimentally induced osteoporosis in laboratory rats. The objective of this study was to determine the subacute and subchronic toxic effects of palm vitamin E extract on mice. This was part of an ongoing effort to determine the potential for use of palm vitamin E as an anti-osteoporotic agent. The doses used in this study were 200, 500 and 1000 mg kg-1. Treatment period was 14 days for the Subacute Toxicity Study and 42 days for the Subchronic Toxicity Study. The parameters measured were Bleeding Time, Clotting Time, serum aspartate aminotransferase, serum creatinine as well as liver and kidney weights. The results showed that the Bleeding and Clotting Times were significantly prolonged in the 500 and 1000 mg kg-1 groups in both the Subacute and Subchronic Toxicity Studies. Serum creatinine was raised in the 500 and 1000 mg kg-1 group for the Subchronic Toxicity Study. Kidney weights were increased in the 200 and 500 mg kg-1 groups for the Subacute Toxicity Study and in the 1000 mg kg-1 group for the Subchronic Toxicity Study. No changes in serum aspartate aminotransferase levels or in liver weights were seen in both the Subacute and Subchronic Toxicity Studies. In conclusion, large doses of palm vitamin E in animals well above the effective dose used to prevent and treat osteoporosis may cause bleeding tendency and renal impairment but there was no liver toxicity.

AB - Palm oil is a rich source of vitamin E, especially the tocotrienols. It had been shown in previous studies to be effective in preventing and treating experimentally induced osteoporosis in laboratory rats. The objective of this study was to determine the subacute and subchronic toxic effects of palm vitamin E extract on mice. This was part of an ongoing effort to determine the potential for use of palm vitamin E as an anti-osteoporotic agent. The doses used in this study were 200, 500 and 1000 mg kg-1. Treatment period was 14 days for the Subacute Toxicity Study and 42 days for the Subchronic Toxicity Study. The parameters measured were Bleeding Time, Clotting Time, serum aspartate aminotransferase, serum creatinine as well as liver and kidney weights. The results showed that the Bleeding and Clotting Times were significantly prolonged in the 500 and 1000 mg kg-1 groups in both the Subacute and Subchronic Toxicity Studies. Serum creatinine was raised in the 500 and 1000 mg kg-1 group for the Subchronic Toxicity Study. Kidney weights were increased in the 200 and 500 mg kg-1 groups for the Subacute Toxicity Study and in the 1000 mg kg-1 group for the Subchronic Toxicity Study. No changes in serum aspartate aminotransferase levels or in liver weights were seen in both the Subacute and Subchronic Toxicity Studies. In conclusion, large doses of palm vitamin E in animals well above the effective dose used to prevent and treat osteoporosis may cause bleeding tendency and renal impairment but there was no liver toxicity.

KW - Mice

KW - Palm vitamin E

KW - Subacute

KW - Subchronic

KW - Toxicity studies

UR - http://www.scopus.com/inward/record.url?scp=80755126534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80755126534&partnerID=8YFLogxK

U2 - 10.3923/jpt.2011.166.173

DO - 10.3923/jpt.2011.166.173

M3 - Article

AN - SCOPUS:80755126534

VL - 6

SP - 166

EP - 173

JO - Journal of Pharmacology and Toxicology

JF - Journal of Pharmacology and Toxicology

SN - 1816-496X

IS - 2

ER -