Study on effectiveness and side effect of mycophenolate mofetil versus azathioprine in maintenance treatment of lupus nephritis

Syazzana Dzulkifli, Kumolosasi Msi Endang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: This study investigated the effects of mycophenolate mofetil and azathioprine on serum creatinine, creatinine clearance and proteinurea in maintenance treatment of lupus nephritis. Methods: This retrospective observational study was carried out in a tertiary hospital. Patients with lupus nephritis were selected as convenience sampling method based on inclusion and exclusion criteria. All the data were obtained from the patients' medical records. Results: No significance differences were observed in mean improvement of serum creatinine, creatinine clearance and proteinurea at after one year treatment with either mycophenolate mofetil or azathioprine. Conclusion: Our study demonstrated that mycophenolate mofetil and azathioprine had similar effectiveness in the maintenance treatment of lupus nephritis.

Original languageEnglish
Pages (from-to)360-362
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume5
Issue numberSUPPL.4
Publication statusPublished - 2013

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Mycophenolic Acid
Lupus Nephritis
Azathioprine
Creatinine
Therapeutics
Serum
Tertiary Care Centers
Medical Records
Observational Studies
Retrospective Studies

Keywords

  • Azathioprine
  • Lupus nephritis
  • Mycophenolate mofetil

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

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abstract = "Objective: This study investigated the effects of mycophenolate mofetil and azathioprine on serum creatinine, creatinine clearance and proteinurea in maintenance treatment of lupus nephritis. Methods: This retrospective observational study was carried out in a tertiary hospital. Patients with lupus nephritis were selected as convenience sampling method based on inclusion and exclusion criteria. All the data were obtained from the patients' medical records. Results: No significance differences were observed in mean improvement of serum creatinine, creatinine clearance and proteinurea at after one year treatment with either mycophenolate mofetil or azathioprine. Conclusion: Our study demonstrated that mycophenolate mofetil and azathioprine had similar effectiveness in the maintenance treatment of lupus nephritis.",
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AU - Dzulkifli, Syazzana

AU - Endang, Kumolosasi Msi

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N2 - Objective: This study investigated the effects of mycophenolate mofetil and azathioprine on serum creatinine, creatinine clearance and proteinurea in maintenance treatment of lupus nephritis. Methods: This retrospective observational study was carried out in a tertiary hospital. Patients with lupus nephritis were selected as convenience sampling method based on inclusion and exclusion criteria. All the data were obtained from the patients' medical records. Results: No significance differences were observed in mean improvement of serum creatinine, creatinine clearance and proteinurea at after one year treatment with either mycophenolate mofetil or azathioprine. Conclusion: Our study demonstrated that mycophenolate mofetil and azathioprine had similar effectiveness in the maintenance treatment of lupus nephritis.

AB - Objective: This study investigated the effects of mycophenolate mofetil and azathioprine on serum creatinine, creatinine clearance and proteinurea in maintenance treatment of lupus nephritis. Methods: This retrospective observational study was carried out in a tertiary hospital. Patients with lupus nephritis were selected as convenience sampling method based on inclusion and exclusion criteria. All the data were obtained from the patients' medical records. Results: No significance differences were observed in mean improvement of serum creatinine, creatinine clearance and proteinurea at after one year treatment with either mycophenolate mofetil or azathioprine. Conclusion: Our study demonstrated that mycophenolate mofetil and azathioprine had similar effectiveness in the maintenance treatment of lupus nephritis.

KW - Azathioprine

KW - Lupus nephritis

KW - Mycophenolate mofetil

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