Study of acute toxicity of Carica papaya leaf extract in Sprague Dawley rats

S. Z. Halim, N. R. Abdullah, A. Afzan, B. A. Abdul Rashid, Ibrahim Jantan, Z. Ismail

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Carica papaya (CP) leaves are popularly used as food and have many traditional claims for herbal medicine. The leaf extract have been proven scientifically for their efficacy as wound healing and has protective effects against gastric damage in rats. However, toxicity study of the CP leaf extract is still lacking. The present study is to investigate the acute toxicity of CP leaf extract on Sprague Dawley rats at a dose of 2000 mg/kg body weight (BW). Sighting study was conducted in a stepwise procedure using the fixed doses of 5, 50, 300 and 2000 mg/kg BW. No signs of toxicity and no deaths were observed. Based on the sighting study, we selected a dose of 2000 mg/kg BW and were observed for 14 days. The study includes control and treatment group, each consisting of 5 female rats. The single oral dose of the CP leaf extract did not produce mortality or significant changes in the body weight, food and water consumption. The relative weights of the internal organs were normal. However, hemoglobin (HGB), hematocrit (HCT), red blood cell (RBC) and total protein were significantly increase indicating dehydration. Apart from triglyceride, other biochemistry parameters demonstrated no significant changes as compared to the control.

Original languageEnglish
Pages (from-to)1867-1872
Number of pages6
JournalJournal of Medicinal Plants Research
Volume5
Issue number10
Publication statusPublished - 18 May 2011
Externally publishedYes

Fingerprint

Carica
Carica papaya
acute toxicity
leaf extracts
Sprague Dawley Rats
Body Weight
rats
fixed dose procedure
body weight
dosage
Food
Organ Size
Body Water
Herbal Medicine
body weight changes
herbal medicines
toxicity testing
tissue repair
Dehydration
Hematocrit

Keywords

  • Acute toxicity
  • Carica papaya
  • Leaf extract

ASJC Scopus subject areas

  • Pharmacology
  • Complementary and alternative medicine
  • Drug Discovery
  • Plant Science
  • Pharmaceutical Science

Cite this

Halim, S. Z., Abdullah, N. R., Afzan, A., Abdul Rashid, B. A., Jantan, I., & Ismail, Z. (2011). Study of acute toxicity of Carica papaya leaf extract in Sprague Dawley rats. Journal of Medicinal Plants Research, 5(10), 1867-1872.

Study of acute toxicity of Carica papaya leaf extract in Sprague Dawley rats. / Halim, S. Z.; Abdullah, N. R.; Afzan, A.; Abdul Rashid, B. A.; Jantan, Ibrahim; Ismail, Z.

In: Journal of Medicinal Plants Research, Vol. 5, No. 10, 18.05.2011, p. 1867-1872.

Research output: Contribution to journalArticle

Halim, SZ, Abdullah, NR, Afzan, A, Abdul Rashid, BA, Jantan, I & Ismail, Z 2011, 'Study of acute toxicity of Carica papaya leaf extract in Sprague Dawley rats', Journal of Medicinal Plants Research, vol. 5, no. 10, pp. 1867-1872.
Halim SZ, Abdullah NR, Afzan A, Abdul Rashid BA, Jantan I, Ismail Z. Study of acute toxicity of Carica papaya leaf extract in Sprague Dawley rats. Journal of Medicinal Plants Research. 2011 May 18;5(10):1867-1872.
Halim, S. Z. ; Abdullah, N. R. ; Afzan, A. ; Abdul Rashid, B. A. ; Jantan, Ibrahim ; Ismail, Z. / Study of acute toxicity of Carica papaya leaf extract in Sprague Dawley rats. In: Journal of Medicinal Plants Research. 2011 ; Vol. 5, No. 10. pp. 1867-1872.
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