Structure of biologically active organotin(IV) dithiocarbamates

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The diorganotin(IV) complexes of dithiocarbamates derived from from N-ethyl-n-propylamine (EtPrdtc), 2-dimethylaminoethylamine (Me 2Etdtc), 3-dimethlyamino-1-propylamine (Me2Prdtc), p-tolylmethanamine (TylMetdtc) and N-methyl-1-phenylmethanamine (MePhMetdtc) have been synthesized and characterized. Single crystal X-ray diffraction studies on Ph3Sn(EtPrdtc), Me2Sn(MePhMetdtc)2 and Bu2Sn(MePhMetdtc)2 showed that the complexes adopted a monoclinic system with space group P(2)/n, P21/n and C2/c, respectively. The Ph3Sn(EtPrdtc) complex adopted a trigonal pyramidal structure while the Me2Sn(MePhMetdtc)2 and Bu 2Sn(MePhMetdtc)2 complexes displayed structures which may be described as distorted octahedrons. Cytotoxicity test using HL60 cells (human promyelocytic leukemic) showed that only Me2Sn(Me2Etdtc), Me2Sn(MePhMetdtc)2 and Bu2Sn(MePhMetdtc) 2 complexes were active. The rest of the complexes did not show cytotoxicity behaviour towards HL60 cells.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages221-223
Number of pages3
Volume989
DOIs
Publication statusPublished - 2008
EventInternational Conference on Neutron and X-ray Scattering 2007, ICNX 2007 - Serpong and Bandung
Duration: 23 Jul 200731 Jul 2007

Other

OtherInternational Conference on Neutron and X-ray Scattering 2007, ICNX 2007
CitySerpong and Bandung
Period23/7/0731/7/07

Fingerprint

octahedrons
cells
single crystals
diffraction
x rays

Keywords

  • Biologically active
  • Organotin dithiocarbamates
  • Structure

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Structure of biologically active organotin(IV) dithiocarbamates. / Abdul Aziz, Yang Farina; Sanuddin, M.; Mohd. Yamin, Bohari.

AIP Conference Proceedings. Vol. 989 2008. p. 221-223.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abdul Aziz, YF, Sanuddin, M & Mohd. Yamin, B 2008, Structure of biologically active organotin(IV) dithiocarbamates. in AIP Conference Proceedings. vol. 989, pp. 221-223, International Conference on Neutron and X-ray Scattering 2007, ICNX 2007, Serpong and Bandung, 23/7/07. https://doi.org/10.1063/1.2906071
Abdul Aziz, Yang Farina ; Sanuddin, M. ; Mohd. Yamin, Bohari. / Structure of biologically active organotin(IV) dithiocarbamates. AIP Conference Proceedings. Vol. 989 2008. pp. 221-223
@inproceedings{6116b71608b046a0ae28d92eb9fc8909,
title = "Structure of biologically active organotin(IV) dithiocarbamates",
abstract = "The diorganotin(IV) complexes of dithiocarbamates derived from from N-ethyl-n-propylamine (EtPrdtc), 2-dimethylaminoethylamine (Me 2Etdtc), 3-dimethlyamino-1-propylamine (Me2Prdtc), p-tolylmethanamine (TylMetdtc) and N-methyl-1-phenylmethanamine (MePhMetdtc) have been synthesized and characterized. Single crystal X-ray diffraction studies on Ph3Sn(EtPrdtc), Me2Sn(MePhMetdtc)2 and Bu2Sn(MePhMetdtc)2 showed that the complexes adopted a monoclinic system with space group P(2)/n, P21/n and C2/c, respectively. The Ph3Sn(EtPrdtc) complex adopted a trigonal pyramidal structure while the Me2Sn(MePhMetdtc)2 and Bu 2Sn(MePhMetdtc)2 complexes displayed structures which may be described as distorted octahedrons. Cytotoxicity test using HL60 cells (human promyelocytic leukemic) showed that only Me2Sn(Me2Etdtc), Me2Sn(MePhMetdtc)2 and Bu2Sn(MePhMetdtc) 2 complexes were active. The rest of the complexes did not show cytotoxicity behaviour towards HL60 cells.",
keywords = "Biologically active, Organotin dithiocarbamates, Structure",
author = "{Abdul Aziz}, {Yang Farina} and M. Sanuddin and {Mohd. Yamin}, Bohari",
year = "2008",
doi = "10.1063/1.2906071",
language = "English",
isbn = "9780735405080",
volume = "989",
pages = "221--223",
booktitle = "AIP Conference Proceedings",

}

TY - GEN

T1 - Structure of biologically active organotin(IV) dithiocarbamates

AU - Abdul Aziz, Yang Farina

AU - Sanuddin, M.

AU - Mohd. Yamin, Bohari

PY - 2008

Y1 - 2008

N2 - The diorganotin(IV) complexes of dithiocarbamates derived from from N-ethyl-n-propylamine (EtPrdtc), 2-dimethylaminoethylamine (Me 2Etdtc), 3-dimethlyamino-1-propylamine (Me2Prdtc), p-tolylmethanamine (TylMetdtc) and N-methyl-1-phenylmethanamine (MePhMetdtc) have been synthesized and characterized. Single crystal X-ray diffraction studies on Ph3Sn(EtPrdtc), Me2Sn(MePhMetdtc)2 and Bu2Sn(MePhMetdtc)2 showed that the complexes adopted a monoclinic system with space group P(2)/n, P21/n and C2/c, respectively. The Ph3Sn(EtPrdtc) complex adopted a trigonal pyramidal structure while the Me2Sn(MePhMetdtc)2 and Bu 2Sn(MePhMetdtc)2 complexes displayed structures which may be described as distorted octahedrons. Cytotoxicity test using HL60 cells (human promyelocytic leukemic) showed that only Me2Sn(Me2Etdtc), Me2Sn(MePhMetdtc)2 and Bu2Sn(MePhMetdtc) 2 complexes were active. The rest of the complexes did not show cytotoxicity behaviour towards HL60 cells.

AB - The diorganotin(IV) complexes of dithiocarbamates derived from from N-ethyl-n-propylamine (EtPrdtc), 2-dimethylaminoethylamine (Me 2Etdtc), 3-dimethlyamino-1-propylamine (Me2Prdtc), p-tolylmethanamine (TylMetdtc) and N-methyl-1-phenylmethanamine (MePhMetdtc) have been synthesized and characterized. Single crystal X-ray diffraction studies on Ph3Sn(EtPrdtc), Me2Sn(MePhMetdtc)2 and Bu2Sn(MePhMetdtc)2 showed that the complexes adopted a monoclinic system with space group P(2)/n, P21/n and C2/c, respectively. The Ph3Sn(EtPrdtc) complex adopted a trigonal pyramidal structure while the Me2Sn(MePhMetdtc)2 and Bu 2Sn(MePhMetdtc)2 complexes displayed structures which may be described as distorted octahedrons. Cytotoxicity test using HL60 cells (human promyelocytic leukemic) showed that only Me2Sn(Me2Etdtc), Me2Sn(MePhMetdtc)2 and Bu2Sn(MePhMetdtc) 2 complexes were active. The rest of the complexes did not show cytotoxicity behaviour towards HL60 cells.

KW - Biologically active

KW - Organotin dithiocarbamates

KW - Structure

UR - http://www.scopus.com/inward/record.url?scp=42449137512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42449137512&partnerID=8YFLogxK

U2 - 10.1063/1.2906071

DO - 10.1063/1.2906071

M3 - Conference contribution

AN - SCOPUS:42449137512

SN - 9780735405080

VL - 989

SP - 221

EP - 223

BT - AIP Conference Proceedings

ER -