Stratifying patients with haematuria into high or low risk groups for bladder cancer

A novel clinical scoring system

Guan Hee Tan, Shamsul Azhar Shah, Ho Sue Ann, Siti Nirhafizah Hemdan, Lim Chun Shen, Nurudin Al Fahmi Abdul Galib, Praveen Singam, Chee Kong Christopher Ho, Eng Hong Goh, Badrulhisham Bahadzor, Zulkifli Md. Zainuddin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Haematuria is a common presentation of bladder cancer and requires a full urologic evaluation. This study aimed to develop a scoring system capable of stratifying patients with haematuria into high or low risk groups for having bladder cancer to help clinicians decide which patients need more urgent assessment. This cross-sectional study included all adult patients referred for haematuria and subsequently undergoing full urological evaluation in the years 2001 to 2011. Risk factors with strong association with bladder cancer in the study population were used to design the scoring system. Accuracy was determined by the area under the receiver operating characteristic (ROC) curve. A total of 325 patients with haematuria were included, out of which 70 (21.5%) were diagnosed to have bladder cancer. Significant risk factors associated with bladder cancer were male gender, a history of cigarette smoking and the presence of gross haematuria. A scoring system using 4 clinical parameters as variables was created. The scores ranged between 6 to 14, and a score of 10 and above indicated high risk for having bladder cancer. It was found to have good accuracy with an area under the ROC curve of 80.4%, while the sensitivity and specificity were 90.0% and 55.7%, respectively. The scoring system designed in this study has the potential to help clinicians stratify patients who present with haematuria into high or low risk for having bladder cancer. This will enable high-risk patients to undergo urologic assessment earlier.

Original languageEnglish
Pages (from-to)6327-6330
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume14
Issue number11
DOIs
Publication statusPublished - 2013

Fingerprint

Hematuria
Urinary Bladder Neoplasms
ROC Curve
Cross-Sectional Studies
Smoking
Sensitivity and Specificity
Population

Keywords

  • Bladder cancer
  • Haematuria
  • Nomogram
  • Risk stratification
  • Scoring system

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

Cite this

Stratifying patients with haematuria into high or low risk groups for bladder cancer : A novel clinical scoring system. / Tan, Guan Hee; Shah, Shamsul Azhar; Ann, Ho Sue; Hemdan, Siti Nirhafizah; Shen, Lim Chun; Abdul Galib, Nurudin Al Fahmi; Singam, Praveen; Ho, Chee Kong Christopher; Goh, Eng Hong; Bahadzor, Badrulhisham; Md. Zainuddin, Zulkifli.

In: Asian Pacific Journal of Cancer Prevention, Vol. 14, No. 11, 2013, p. 6327-6330.

Research output: Contribution to journalArticle

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