Strategies for antimicrobial drug delivery to biofilm

Claire Martin, Wan Li Low, Abhishek Gupta, Mohd Cairul Iqbal Mohd Amin, Iza Radecka, Stephen T. Britland, Prem Raj, Ken Kenward

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Biofilms are formed by the attachment of single or mixed microbial communities to a variety of biological and/or synthetic surfaces. Biofilm micro-organisms benefit from many advantages of the polymicrobial environment including increased resistance against antimicrobials and protection against the host organism’s defence mechanisms. These benefits stem from a number of structural and physiological differences between planktonic and biofilm-resident microbes, but two main factors are the presence of extracellular polymeric substances (EPS) and quorum sensing communication. Once formed, biofilms begin to synthesise EPS, a complex viscous matrix composed of a variety of macromolecules including proteins, lipids and polysaccharides. In terms of drug delivery strategies, it is the EPS that presents the greatest barrier to diffusion for drug delivery systems and free antimicrobial agents alike. In addition to EPS synthesis, biofilm-based micro-organisms can also produce small, diffusible signalling molecules involved in cell density-dependent intercellular communication, or quorum sensing. Not only does quorum sensing allow microbes to detect critical cell density numbers, but it also permits co-ordinated behaviour within the biofilm, such as iron chelation and defensive antibiotic activities. Against this backdrop of microbial defence and cell density-specific communication, a variety of drug delivery systems have been developed to deliver antimicrobial agents and antibiotics to extracellular and/or intracellular targets, or more recently, to interfere with the specific mechanisms of quorum sensing. Successful delivery strategies have employed lipidic and polymeric-based formulations such as liposomes and cyclodextrins respectively, in addition to inorganic carriers e.g. metal nanoparticles. This review will examine a range of drug delivery systems and their application to biofilm delivery, as well as pharmaceutical formulations with innate antimicrobial properties such as silver nanoparticles and microemulsions.

Original languageEnglish
Pages (from-to)43-66
Number of pages24
JournalCurrent Pharmaceutical Design
Volume21
Issue number1
Publication statusPublished - 1 Dec 2015

Fingerprint

Biofilms
Quorum Sensing
Pharmaceutical Preparations
Drug Delivery Systems
Cell Count
Anti-Infective Agents
Metal Nanoparticles
Anti-Bacterial Agents
Drug Compounding
Cyclodextrins
Silver
Liposomes
Nanoparticles
Polysaccharides
Iron
Lipids
Proteins

Keywords

  • Antimicrobial agents
  • Biofilm
  • Controlled release
  • Copper
  • Cyclodextrins
  • Dendrimers
  • Drug delivery systems
  • Gold
  • Iron salts
  • Liposomes
  • Micro- and nanoparticles
  • Microemulsions
  • Silver
  • Smart polymers
  • Solid lipid nanoparticles
  • Zinc

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Martin, C., Low, W. L., Gupta, A., Mohd Amin, M. C. I., Radecka, I., Britland, S. T., ... Kenward, K. (2015). Strategies for antimicrobial drug delivery to biofilm. Current Pharmaceutical Design, 21(1), 43-66.

Strategies for antimicrobial drug delivery to biofilm. / Martin, Claire; Low, Wan Li; Gupta, Abhishek; Mohd Amin, Mohd Cairul Iqbal; Radecka, Iza; Britland, Stephen T.; Raj, Prem; Kenward, Ken.

In: Current Pharmaceutical Design, Vol. 21, No. 1, 01.12.2015, p. 43-66.

Research output: Contribution to journalArticle

Martin, C, Low, WL, Gupta, A, Mohd Amin, MCI, Radecka, I, Britland, ST, Raj, P & Kenward, K 2015, 'Strategies for antimicrobial drug delivery to biofilm', Current Pharmaceutical Design, vol. 21, no. 1, pp. 43-66.
Martin C, Low WL, Gupta A, Mohd Amin MCI, Radecka I, Britland ST et al. Strategies for antimicrobial drug delivery to biofilm. Current Pharmaceutical Design. 2015 Dec 1;21(1):43-66.
Martin, Claire ; Low, Wan Li ; Gupta, Abhishek ; Mohd Amin, Mohd Cairul Iqbal ; Radecka, Iza ; Britland, Stephen T. ; Raj, Prem ; Kenward, Ken. / Strategies for antimicrobial drug delivery to biofilm. In: Current Pharmaceutical Design. 2015 ; Vol. 21, No. 1. pp. 43-66.
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