Stomach specific polymeric low density microballoons as a vector for extended delivery of rabeprazole and amoxicillin for treatment of peptic ulcer

Sandeep Choudhary, Ashay Jain, Mohd Cairul Iqbal Mohd Amin, Vijay Mishra, Govind P. Agrawal, Prashant Kesharwani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The study was intended to develop a new intra-gastric floating in situ microballoons system for controlled delivery of rabeprazole sodium and amoxicillin trihydrate for the treatment of peptic ulcer disease. Eudragit S-100 and hydroxypropyl methyl cellulose based low density microballoons systems were fabricated by employing varying concentrations of Eudragit S-100 and hydroxypropyl methyl cellulose, to which varying concentrations of drug was added, and formulated by stirring at various speed and time to optimize the process and formulation variable. The formulation variables like concentration and ratio of polymers significantly affected the in vitro drug release from the prepared floating device. The validation of the gastro-retentive potential of the prepared microballoons was carried out in rabbits by orally administration of microballoons formulation containing radio opaque material. The developed formulations showed improved buoyancy and lower ulcer index as compared to that seen with plain drugs. Ulcer protective efficacies were confirmed in ulcer-bearing mouse model. In conclusion, greater compatibility, higher gastro-retention and higher anti-ulcer activity of the presently fabricated formulations to improve potential of formulation for redefining ulcer treatment are presented here. These learning exposed a targeted and sustained drug delivery potential of prepared microballoons in gastric region for ulcer therapeutic intervention as corroborated by in vitro and in vivo findings and, thus, deserves further attention for improved ulcer treatment.

Original languageEnglish
Pages (from-to)268-277
Number of pages10
JournalColloids and Surfaces B: Biointerfaces
Volume141
DOIs
Publication statusPublished - 1 May 2016

Fingerprint

microballoons
Rabeprazole
ulcers
stomach
Amoxicillin
Peptic Ulcer
Ulcer
Cellulose
delivery
Stomach
Bearings (structural)
Buoyancy
Drug delivery
formulations
Pharmaceutical Preparations
drugs
Sodium
Polymers
Therapeutics
cellulose

Keywords

  • Amoxicillin trihydrate
  • Buoyancy
  • Floating drug delivery system
  • Microballoons
  • Rabeprazole sodium

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Stomach specific polymeric low density microballoons as a vector for extended delivery of rabeprazole and amoxicillin for treatment of peptic ulcer. / Choudhary, Sandeep; Jain, Ashay; Mohd Amin, Mohd Cairul Iqbal; Mishra, Vijay; Agrawal, Govind P.; Kesharwani, Prashant.

In: Colloids and Surfaces B: Biointerfaces, Vol. 141, 01.05.2016, p. 268-277.

Research output: Contribution to journalArticle

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