Stimuli-responsive bacterial cellulose-g-poly(acrylic acid-co-acrylamide) hydrogels for oral controlled release drug delivery

Mohd Cairul Iqbal Mohd Amin, Naveed Ahmad, Manisha Pandey, Chong Jue Xin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This study evaluated the potential of stimuli-responsive bacterial cellulose-g-poly(acrylic acid-co-acrylamide) hydrogels as oral controlled-release drug delivery carriers. Hydrogels were synthesized by graft copolymerization of the monomers onto bacterial cellulose (BC) fibers by using a microwave irradiation technique. The hydrogels were characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). FT-IR spectroscopy confirmed the grafting. XRD showed that the crystallinity of BC was reduced by grafting, whereas an increase in the thermal stability profile was observed in TGA. SEM showed that the hydrogels exhibited a highly porous morphology, which is suitable for drug loading. The hydrogels demonstrated a pH-responsive swelling behavior, with decreased swelling in acidic media, which increased with increase in pH of the media, reaching maximum swelling at pH 7. The release profile of the hydrogels was investigated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The hydrogels showed lesser release in SGF than in SIF, suggesting that hydrogels may be suitable drug carriers for oral controlled release of drug delivery in the lower gastrointestinal tract.

Original languageEnglish
Pages (from-to)1340-1349
Number of pages10
JournalDrug Development and Industrial Pharmacy
Volume40
Issue number10
DOIs
Publication statusPublished - 2014

Fingerprint

Hydrogels
Drug delivery
Cellulose
Swelling
Drug Carriers
Fluids
Fourier Transform Infrared Spectroscopy
X-Ray Diffraction
Electron Scanning Microscopy
Thermogravimetric analysis
Stomach
Lower Gastrointestinal Tract
X ray diffraction
Scanning electron microscopy
Microwave irradiation
poly(acrylamide-co-acrylic acid)
Drug Liberation
Microwaves
Grafts
Copolymerization

Keywords

  • Bacterial cellulose
  • Controlled release
  • Drug delivery
  • Hydrogels
  • Responsive index

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry

Cite this

Stimuli-responsive bacterial cellulose-g-poly(acrylic acid-co-acrylamide) hydrogels for oral controlled release drug delivery. / Mohd Amin, Mohd Cairul Iqbal; Ahmad, Naveed; Pandey, Manisha; Jue Xin, Chong.

In: Drug Development and Industrial Pharmacy, Vol. 40, No. 10, 2014, p. 1340-1349.

Research output: Contribution to journalArticle

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