Stem cells, cytokines and their receptors

Shahrul Hisham Zainal Ariffin, Rohaya Megat Abdul Wahab, Ismanizan Ismail, Nor Muhammad Mahadi, Zaidah Zainal Ariffin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Stem cells that have totipotent, pluripotent and multipotent abilities can be divided into two main categories: embryonic stem cells and adult stem cells. Embryonic stem cells originate from the inner cell mass of the blastocyst stage during embryonic development whereas adult stem cells are derived from bone marrow. Stem cells have the ability to differentiate into mature cells or transdifferentiate into other tissues partly due to cellular signals triggered by the growth factors such as cytokines. Cytokines produce cellular signals through the cytoplasmic domain of their cognate receptor. Cytokine receptors have been categorised into several superfamilies followed by subfamilies partly due to structural similarities (extracellular and cytoplasmic domains) and combination of subunits. The ability of IL-3 to trigger differentiation not only to haemopoietic stem cells but also to liver stem cells might be a potential factor for transdifferentiation. IL-3, GM-CSF and IL-5 receptors are members of a common â subfamily because they share the same â subunit known as â common (âc). This review focuses on the â subfamily and in particular on their potential signalling pathways, i.e. proliferation, differentiation and survival that triggers at the cytoplasmic domain of both subunits (α subunits and âc) on the stem cells.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalAsia-Pacific Journal of Molecular Biology and Biotechnology
Volume13
Issue number1
Publication statusPublished - 2005

Fingerprint

Cytokine Receptors
Stem Cells
Adult Stem Cells
Interleukin-3
Embryonic Stem Cells
Totipotent Stem Cells
Interleukin-5 Receptors
Blastocyst Inner Cell Mass
Cytokines
Multipotent Stem Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Embryonic Development
Intercellular Signaling Peptides and Proteins
Bone Marrow
Liver

Keywords

  • Âc subunit
  • Cellular signals
  • Cytoplasmic domain
  • Stem cells
  • Α subunit

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

Cite this

Stem cells, cytokines and their receptors. / Zainal Ariffin, Shahrul Hisham; Megat Abdul Wahab, Rohaya; Ismail, Ismanizan; Mahadi, Nor Muhammad; Ariffin, Zaidah Zainal.

In: Asia-Pacific Journal of Molecular Biology and Biotechnology, Vol. 13, No. 1, 2005, p. 1-13.

Research output: Contribution to journalArticle

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