Stem cell therapy in neurodegenerative diseases: From principles to practice

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The lack of curative therapies for neurodegenerative diseases has high economic impact and places huge burden on the society. The contribution of stem cells to cure neurodegenerative diseases has been unraveled and explored extensively over the past few years. Beyond substitution of the lost neurons, stem cells act as immunomodulators and neuroprotectors. A large number of preclinical and a small number of clinical studies have shown beneficial outcomes in this context. In this review, we have summarized the current concepts of stem cell therapy in neurodegenerative diseases and the recent advances in this field, particularly between 2010 and 2012. Further studies should be encouraged to resolve the clinical issues and vague translational findings for maximum optimization of the efficacy of stem cell therapy in neurodegenerative diseases.

Original languageEnglish
Pages (from-to)1822-1831
Number of pages10
JournalNeural Regeneration Research
Volume7
Issue number23
DOIs
Publication statusPublished - 15 Aug 2012

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Cell- and Tissue-Based Therapy
Neurodegenerative Diseases
Stem Cells
Immunologic Factors
Economics
Neurons
Therapeutics

Keywords

  • Alzheimer’s disease
  • Amyotrophic lateral sclerosis
  • Embryonic stem cells
  • Huntington’s disease
  • Induced pluripotent stem cells
  • Mesenchymal stem cells
  • Neural stem cells
  • Neurodegenerative diseases
  • Parkinson’s disease
  • Stem cells

ASJC Scopus subject areas

  • Developmental Neuroscience

Cite this

Stem cell therapy in neurodegenerative diseases : From principles to practice. / Rajalingham, Sakthiswary; Ali, Raymond Azman.

In: Neural Regeneration Research, Vol. 7, No. 23, 15.08.2012, p. 1822-1831.

Research output: Contribution to journalArticle

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