Spectrum of nocardiosis in renal patients.

N. C. Kong, Z. Morad, A. B. Suleiman, I. K. Cheong, I. Lajin

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Nocardiosis is an increasingly recognised opportunistic infection in immunologically incompetent hosts but diagnosis is often delayed. Between December 1975 to October 1988, our two Nephrology Units have encountered five cases of nocardiosis occurring in two post-renal transplant patients, two patients with systemic lupus erythematous (SLE) and one patient with mesangiocapillary glomerulo--nephritis. All were on immunosuppressants at the time. The first three patients presented with predominant pulmonary disease and were cured by combined trimethoprim-sulphamethoxazole (cotrimoxazole) and doxycycline therapy. The patient with limited skin involvement responded to cotrimoxazole alone. However, the last patient with lymphocutaneous disease initially responded to cotrimoxazole (+ chloramphenicol) but developed acute-on-chronic renal failure and relapsed with dose reduction of cotrimoxazole. Alternative treatment with amikacin and doxycycline was instituted with good response. We shall review potential clues that may suggest the diagnosis of nocardiosis and discuss other effective antimicrobial agents.

    Original languageEnglish
    Pages (from-to)375-379
    Number of pages5
    JournalAnnals of the Academy of Medicine Singapore
    Volume19
    Issue number3
    Publication statusPublished - May 1990

    Fingerprint

    Nocardia Infections
    Sulfamethoxazole
    Trimethoprim
    Kidney
    Doxycycline
    Nephrology
    Amikacin
    Nephritis
    Opportunistic Infections
    Chloramphenicol
    Immunosuppressive Agents
    Anti-Infective Agents
    Lung Diseases
    Chronic Kidney Failure
    Transplants
    Skin
    Therapeutics

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Kong, N. C., Morad, Z., Suleiman, A. B., Cheong, I. K., & Lajin, I. (1990). Spectrum of nocardiosis in renal patients. Annals of the Academy of Medicine Singapore, 19(3), 375-379.

    Spectrum of nocardiosis in renal patients. / Kong, N. C.; Morad, Z.; Suleiman, A. B.; Cheong, I. K.; Lajin, I.

    In: Annals of the Academy of Medicine Singapore, Vol. 19, No. 3, 05.1990, p. 375-379.

    Research output: Contribution to journalArticle

    Kong, NC, Morad, Z, Suleiman, AB, Cheong, IK & Lajin, I 1990, 'Spectrum of nocardiosis in renal patients.', Annals of the Academy of Medicine Singapore, vol. 19, no. 3, pp. 375-379.
    Kong NC, Morad Z, Suleiman AB, Cheong IK, Lajin I. Spectrum of nocardiosis in renal patients. Annals of the Academy of Medicine Singapore. 1990 May;19(3):375-379.
    Kong, N. C. ; Morad, Z. ; Suleiman, A. B. ; Cheong, I. K. ; Lajin, I. / Spectrum of nocardiosis in renal patients. In: Annals of the Academy of Medicine Singapore. 1990 ; Vol. 19, No. 3. pp. 375-379.
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