Spectral sensitivity in patients with dysthyroid eye disease

Sharanjeet Kaur Malkeet Singh, Chris M. Dickinson, Eammon O'Donoghue, Ian J. Murray

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The majority of patients with dysthyroid eye disease have an acquired colour vision defect. However, no psychophysical investigation of selective damage to colour or flicker pathways has been carried out. In order to clarify the nature of the visual pathology, we have used a psychophysical technique (spectral sensitivity) to selectively stimulate the chromatic and achromatic mechanisms. Spectral spots of size 1°presented at a rate of 1 Hz on a bright 1000 td white background are detected by the chromatic mechanism but a rate of 25 Hz reveals the achromatic mechanism. Fifteen patients (28 eyes) between the ages of 50-70 years were tested. The study showed that all patients had reduced spectral sensitivity, either 1 Hz, 25 Hz or both. The patients with reduced 1 Hz or 25 Hz spectral sensitivity only had a shorter systemic and ocular duration of the condition, had no proptosis, normal intraocular pressures in primary gaze, slightly higher intraocular pressures on upgaze, normal visual field plots and FM 100-Hue error scores higher than the normal age-matched values. The patients with reduced both 1 Hz and 25 Hz spectral sensitivities had a longer systemic and ocular duration of the condition, had proptosis, normal intraocular pressures in primary position, higher intraocular pressures on upgaze and higher FM 100-Hue error scores than the age-matched normals and those in Groups 1 and 2. A total of 50% of patients in Group 3 had defective visual field plots. These data suggest that there is damage of the large achromatic fibres and small chromatic fibres in dysthyroid eye disease. The mechanism of the damage could be one of ischaemic or mechanical or both.

Original languageEnglish
Pages (from-to)232-238
Number of pages7
JournalOphthalmic and Physiological Optics
Volume17
Issue number3
DOIs
Publication statusPublished - May 1997

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Eye Diseases
Intraocular Pressure
Color
Exophthalmos
Visual Fields
Color Vision Defects
Pathology

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Health Professions(all)

Cite this

Spectral sensitivity in patients with dysthyroid eye disease. / Malkeet Singh, Sharanjeet Kaur; Dickinson, Chris M.; O'Donoghue, Eammon; Murray, Ian J.

In: Ophthalmic and Physiological Optics, Vol. 17, No. 3, 05.1997, p. 232-238.

Research output: Contribution to journalArticle

Malkeet Singh, Sharanjeet Kaur ; Dickinson, Chris M. ; O'Donoghue, Eammon ; Murray, Ian J. / Spectral sensitivity in patients with dysthyroid eye disease. In: Ophthalmic and Physiological Optics. 1997 ; Vol. 17, No. 3. pp. 232-238.
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