Spectral characterization and crystal structures of two newly synthesized ligands of N-methyl o-substituted benzohydroxamic acids

Khan Naqeebullah, Yang Farina Abdul Aziz, Lo Kong Mun, Nor Fadilah Rajab, Normah Awang

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1 Citation (Scopus)

Abstract

Two new derivatives of hydroxamic acid having the general formula RC(O)N(RN)OH (R = alkyl/aryl; RN = alkyl/aryl or H), have been synthesized by the condensation method in an ice-bath. The compounds, N-methyl o-iodobenzohydroxamic acid and N-methyl o-bromobenzohydroxamic acid have been isolated as crystalline solids, stable in air and soluble in organic solvents and in aqueous alcohol solution. A systematic investigation of the derivatives were carried out both in solid and in solution. They have been structurally characterized by elemental analysis, and the results were in good agreement with the values calculated for the proposed formula. These derivatives were further investigated on the basis of FT-IR, multinuclear 1H, 13C NMR spectroscopy, and Single Crystal X-ray crystallographic studies, indicating that both the compounds are structurally similar. Graphical Abstract: Two new compounds of hydroxamic acid have been synthesized by condensation method and were structurally characterized by elemental analysis, FT-IR, multinuclear 1H, 13C NMR spectroscopy, and Single Crystal X-ray crystallographic studies. Figure 3 Thermal ellipsoidal plot of C8 H8 Br N O2. Displacement ellipsoids are drawn at the 50 % probability level, and H atoms are shown as spheres of arbitrary radii.[Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)622-627
Number of pages6
JournalJournal of Chemical Crystallography
Volume43
Issue number11
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Hydroxamic Acids
Crystal structure
Ligands
Derivatives
ligands
Nuclear magnetic resonance spectroscopy
acids
crystal structure
Condensation
Single crystals
X rays
Acids
condensation
Ice
Chemical analysis
Organic solvents
nuclear magnetic resonance
single crystals
ellipsoids
Alcohols

Keywords

  • CHN
  • Hydroxamic acids
  • NMR spectroscopy
  • X-ray diffraction

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

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title = "Spectral characterization and crystal structures of two newly synthesized ligands of N-methyl o-substituted benzohydroxamic acids",
abstract = "Two new derivatives of hydroxamic acid having the general formula RC(O)N(RN)OH (R = alkyl/aryl; RN = alkyl/aryl or H), have been synthesized by the condensation method in an ice-bath. The compounds, N-methyl o-iodobenzohydroxamic acid and N-methyl o-bromobenzohydroxamic acid have been isolated as crystalline solids, stable in air and soluble in organic solvents and in aqueous alcohol solution. A systematic investigation of the derivatives were carried out both in solid and in solution. They have been structurally characterized by elemental analysis, and the results were in good agreement with the values calculated for the proposed formula. These derivatives were further investigated on the basis of FT-IR, multinuclear 1H, 13C NMR spectroscopy, and Single Crystal X-ray crystallographic studies, indicating that both the compounds are structurally similar. Graphical Abstract: Two new compounds of hydroxamic acid have been synthesized by condensation method and were structurally characterized by elemental analysis, FT-IR, multinuclear 1H, 13C NMR spectroscopy, and Single Crystal X-ray crystallographic studies. Figure 3 Thermal ellipsoidal plot of C8 H8 Br N O2. Displacement ellipsoids are drawn at the 50 {\%} probability level, and H atoms are shown as spheres of arbitrary radii.[Figure not available: see fulltext.]",
keywords = "CHN, Hydroxamic acids, NMR spectroscopy, X-ray diffraction",
author = "Khan Naqeebullah and {Abdul Aziz}, {Yang Farina} and Mun, {Lo Kong} and Rajab, {Nor Fadilah} and Normah Awang",
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language = "English",
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TY - JOUR

T1 - Spectral characterization and crystal structures of two newly synthesized ligands of N-methyl o-substituted benzohydroxamic acids

AU - Naqeebullah, Khan

AU - Abdul Aziz, Yang Farina

AU - Mun, Lo Kong

AU - Rajab, Nor Fadilah

AU - Awang, Normah

PY - 2013/11

Y1 - 2013/11

N2 - Two new derivatives of hydroxamic acid having the general formula RC(O)N(RN)OH (R = alkyl/aryl; RN = alkyl/aryl or H), have been synthesized by the condensation method in an ice-bath. The compounds, N-methyl o-iodobenzohydroxamic acid and N-methyl o-bromobenzohydroxamic acid have been isolated as crystalline solids, stable in air and soluble in organic solvents and in aqueous alcohol solution. A systematic investigation of the derivatives were carried out both in solid and in solution. They have been structurally characterized by elemental analysis, and the results were in good agreement with the values calculated for the proposed formula. These derivatives were further investigated on the basis of FT-IR, multinuclear 1H, 13C NMR spectroscopy, and Single Crystal X-ray crystallographic studies, indicating that both the compounds are structurally similar. Graphical Abstract: Two new compounds of hydroxamic acid have been synthesized by condensation method and were structurally characterized by elemental analysis, FT-IR, multinuclear 1H, 13C NMR spectroscopy, and Single Crystal X-ray crystallographic studies. Figure 3 Thermal ellipsoidal plot of C8 H8 Br N O2. Displacement ellipsoids are drawn at the 50 % probability level, and H atoms are shown as spheres of arbitrary radii.[Figure not available: see fulltext.]

AB - Two new derivatives of hydroxamic acid having the general formula RC(O)N(RN)OH (R = alkyl/aryl; RN = alkyl/aryl or H), have been synthesized by the condensation method in an ice-bath. The compounds, N-methyl o-iodobenzohydroxamic acid and N-methyl o-bromobenzohydroxamic acid have been isolated as crystalline solids, stable in air and soluble in organic solvents and in aqueous alcohol solution. A systematic investigation of the derivatives were carried out both in solid and in solution. They have been structurally characterized by elemental analysis, and the results were in good agreement with the values calculated for the proposed formula. These derivatives were further investigated on the basis of FT-IR, multinuclear 1H, 13C NMR spectroscopy, and Single Crystal X-ray crystallographic studies, indicating that both the compounds are structurally similar. Graphical Abstract: Two new compounds of hydroxamic acid have been synthesized by condensation method and were structurally characterized by elemental analysis, FT-IR, multinuclear 1H, 13C NMR spectroscopy, and Single Crystal X-ray crystallographic studies. Figure 3 Thermal ellipsoidal plot of C8 H8 Br N O2. Displacement ellipsoids are drawn at the 50 % probability level, and H atoms are shown as spheres of arbitrary radii.[Figure not available: see fulltext.]

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