"SPE-LC-Mass spectrometry analysis for basic pharmaceuticals with different therapeutic classes in aquatic environment: A review"

Fouad Fadhil Mohamed, Md. Pauzi Abdullah, Mohamed Rozali Othman, Zuriaty Binti Zakeria

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Large quantities of pharmaceuticals are used today in human and veterinary medicine and many of these pharmaceuticals are excreted without being entirely metabolized in human or animal, so these pharmaceutical residues in aquatic environment are considered sever contaminants. Requirements for analytical methods is necessary to determine the levels of these pharmaceuticals. Progress in instrumental analytical chemistry has resulted in the availability of methods that allow a monitoring of these contaminates at ng/L levels. In the current article, a review of the Liquid Chromatography instruments provided with tandem mass, TOF, Q-TOF, Micro Triple Mass and so on, based methods published so far for determination of pharmaceuticals in the aquatic environment is presented. Pharmaceuticals included in this review are eleven with different therapeutic classes: anti hypertensive, antibiotic, antidiabetic, inhabit stomach acid, simultant, harmonal contraception, anticonvulsant, bronchodilator, lipid lowering agent. This review also covers the new methodology, including sample pretreatment, solid phase extraction and matrix effect are discussed.

Original languageEnglish
Pages (from-to)2124-2132
Number of pages9
JournalJournal of Applied Sciences Research
Volume8
Issue number4
Publication statusPublished - Apr 2012

Fingerprint

Mass spectrometry
Pharmaceutical Preparations
Veterinary medicine
Bronchodilator Agents
Liquid chromatography
Hypoglycemic Agents
Anticonvulsants
Antihypertensive Agents
Animals
Availability
Impurities
Anti-Bacterial Agents
Lipids
Acids
Monitoring
Chemical analysis

Keywords

  • Aquatic environment
  • Basic pharmaceuticals
  • Lod
  • Multi-residue analysis
  • SPE-LC

ASJC Scopus subject areas

  • General

Cite this

"SPE-LC-Mass spectrometry analysis for basic pharmaceuticals with different therapeutic classes in aquatic environment : A review". / Mohamed, Fouad Fadhil; Abdullah, Md. Pauzi; Othman, Mohamed Rozali; Zakeria, Zuriaty Binti.

In: Journal of Applied Sciences Research, Vol. 8, No. 4, 04.2012, p. 2124-2132.

Research output: Contribution to journalArticle

Mohamed, Fouad Fadhil ; Abdullah, Md. Pauzi ; Othman, Mohamed Rozali ; Zakeria, Zuriaty Binti. / "SPE-LC-Mass spectrometry analysis for basic pharmaceuticals with different therapeutic classes in aquatic environment : A review". In: Journal of Applied Sciences Research. 2012 ; Vol. 8, No. 4. pp. 2124-2132.
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