Soursop (Anona muricata L.): Blood hematology and serum biochemistry of sprague-dawley rats

M. Syahida, Mohamad Yusof Maskat, R. Suri, S. Mamot, H. Hadijah

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study was aimed to evaluate the effect of soursop (Annona muricata L.) extract on Sprague-Dawley rats subjected to in vivo 28-day repeated doses. The extract was given to the study group via force feeding. In the 28-day study, Annona muricata L. extract was dosed at 0 (CD, control dose), 0.5 (LD, low dose), 1.0 (MD, medium dose), 2.0g/kg (HD, high dose) body weight. For control group, distilled water was given to the animals. Administration of Annona muricata L. extract did not cause negative effect in blood hematology even though a statistically significant (p<0.05) increase in platelet level was noted. Result from serum biochemical test showed that the consumption of the extract did not result in liver and kidney failure. The total antioxidant status (TAS) increased significantly as the dosages increased. However the incresase were within the normal laboratory limits.

Original languageEnglish
Pages (from-to)955-959
Number of pages5
JournalInternational Food Research Journal
Volume19
Issue number3
Publication statusPublished - 2012

Fingerprint

soursops
Annona
Hematology
hematology
blood serum
Biochemistry
biochemistry
Sprague Dawley Rats
Annona muricata
rats
blood
dosage
Serum
extracts
Liver Failure
Enteral Nutrition
forced feeding
Renal Insufficiency
liver failure
Blood Platelets

Keywords

  • Blood hematology
  • Serum biochemistry
  • Soursop
  • Sprague-dawley

ASJC Scopus subject areas

  • Food Science

Cite this

Soursop (Anona muricata L.) : Blood hematology and serum biochemistry of sprague-dawley rats. / Syahida, M.; Maskat, Mohamad Yusof; Suri, R.; Mamot, S.; Hadijah, H.

In: International Food Research Journal, Vol. 19, No. 3, 2012, p. 955-959.

Research output: Contribution to journalArticle

@article{1b2e1ffad8e8433ab9d7310f891fe3c8,
title = "Soursop (Anona muricata L.): Blood hematology and serum biochemistry of sprague-dawley rats",
abstract = "This study was aimed to evaluate the effect of soursop (Annona muricata L.) extract on Sprague-Dawley rats subjected to in vivo 28-day repeated doses. The extract was given to the study group via force feeding. In the 28-day study, Annona muricata L. extract was dosed at 0 (CD, control dose), 0.5 (LD, low dose), 1.0 (MD, medium dose), 2.0g/kg (HD, high dose) body weight. For control group, distilled water was given to the animals. Administration of Annona muricata L. extract did not cause negative effect in blood hematology even though a statistically significant (p<0.05) increase in platelet level was noted. Result from serum biochemical test showed that the consumption of the extract did not result in liver and kidney failure. The total antioxidant status (TAS) increased significantly as the dosages increased. However the incresase were within the normal laboratory limits.",
keywords = "Blood hematology, Serum biochemistry, Soursop, Sprague-dawley",
author = "M. Syahida and Maskat, {Mohamad Yusof} and R. Suri and S. Mamot and H. Hadijah",
year = "2012",
language = "English",
volume = "19",
pages = "955--959",
journal = "International Food Research Journal",
issn = "1985-4668",
publisher = "Universiti Putra Malaysia",
number = "3",

}

TY - JOUR

T1 - Soursop (Anona muricata L.)

T2 - Blood hematology and serum biochemistry of sprague-dawley rats

AU - Syahida, M.

AU - Maskat, Mohamad Yusof

AU - Suri, R.

AU - Mamot, S.

AU - Hadijah, H.

PY - 2012

Y1 - 2012

N2 - This study was aimed to evaluate the effect of soursop (Annona muricata L.) extract on Sprague-Dawley rats subjected to in vivo 28-day repeated doses. The extract was given to the study group via force feeding. In the 28-day study, Annona muricata L. extract was dosed at 0 (CD, control dose), 0.5 (LD, low dose), 1.0 (MD, medium dose), 2.0g/kg (HD, high dose) body weight. For control group, distilled water was given to the animals. Administration of Annona muricata L. extract did not cause negative effect in blood hematology even though a statistically significant (p<0.05) increase in platelet level was noted. Result from serum biochemical test showed that the consumption of the extract did not result in liver and kidney failure. The total antioxidant status (TAS) increased significantly as the dosages increased. However the incresase were within the normal laboratory limits.

AB - This study was aimed to evaluate the effect of soursop (Annona muricata L.) extract on Sprague-Dawley rats subjected to in vivo 28-day repeated doses. The extract was given to the study group via force feeding. In the 28-day study, Annona muricata L. extract was dosed at 0 (CD, control dose), 0.5 (LD, low dose), 1.0 (MD, medium dose), 2.0g/kg (HD, high dose) body weight. For control group, distilled water was given to the animals. Administration of Annona muricata L. extract did not cause negative effect in blood hematology even though a statistically significant (p<0.05) increase in platelet level was noted. Result from serum biochemical test showed that the consumption of the extract did not result in liver and kidney failure. The total antioxidant status (TAS) increased significantly as the dosages increased. However the incresase were within the normal laboratory limits.

KW - Blood hematology

KW - Serum biochemistry

KW - Soursop

KW - Sprague-dawley

UR - http://www.scopus.com/inward/record.url?scp=84864814376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864814376&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84864814376

VL - 19

SP - 955

EP - 959

JO - International Food Research Journal

JF - International Food Research Journal

SN - 1985-4668

IS - 3

ER -