Smooth muscle relaxant activities of compounds isolated from Malaysian medicinal plants on rat aorta and guinea-pig ileum

M. R. Mustafa, R. Mohamad, L. Din, S. Wahid

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Muscle relaxant activities of six compounds isolated from Malaysian medicinal plants were investigated on the smooth muscles of the rat aorta and longitudinal muscle of the guinea-pig ileum. Except for goniothalamin, the other five compounds exhibited varying degrees of muscle relaxant activities on the two smooth muscles. Dicentrine, isocorydine, altholactone and usnic acid reduced the contractions to KCl and phenylephrine in the rat aorta, whilst atranorin slightly reduced the contractions to phenylephrine but not KCl. In addition, dicentrine and isocorydine markedly reduced the contractile response to phenylephrine in Ca2+-free Krebs solution. In the longitudinal muscle of the guinea-pig ileum, altholactone, atranorin, dicentrine and isocorydine inhibited to a greater extent the phasic than the tonic responses to KCl. All four compounds similarly inhibited the contractions induced by ACh. The results suggest that the relaxant activities of the compounds are attributed mainly to inhibition of Ca2+ influx via the calcium channels in the membrane of the smooth muscles. Furthermore, the! greater sensitivity of dicentrine, isocorydine and altholactone against phenylephrine-induced contractions or KCl-induced phasic contractions are due to their abilities to inhibit intracellular Ca2+ release in these muscles.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalPhytotherapy Research
Volume9
Issue number8
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

isocorydine
Medicinal Plants
Ileum
Smooth Muscle
Muscle
Aorta
Rats
Phenylephrine
Guinea Pigs
Muscles
Calcium Channels
Membranes
dicentrine

Keywords

  • Calcium
  • Calcium-free
  • Guinea-pig ileum
  • Plant products
  • Rat aorta

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Smooth muscle relaxant activities of compounds isolated from Malaysian medicinal plants on rat aorta and guinea-pig ileum. / Mustafa, M. R.; Mohamad, R.; Din, L.; Wahid, S.

In: Phytotherapy Research, Vol. 9, No. 8, 1995, p. 555-558.

Research output: Contribution to journalArticle

Mustafa, M. R. ; Mohamad, R. ; Din, L. ; Wahid, S. / Smooth muscle relaxant activities of compounds isolated from Malaysian medicinal plants on rat aorta and guinea-pig ileum. In: Phytotherapy Research. 1995 ; Vol. 9, No. 8. pp. 555-558.
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