Sleep related epilepsy and pharmacotherapy

An insight

Jaya Kumar, Amro Solaiman, Pasuk Mahakkanukrauh, Rashidi Mohamed Pakri Mohamed, Srijit Das

Research output: Contribution to journalReview article

Abstract

In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state. Sleep comprises two distinct stages i.e., non-rapid eye movement (NREM) and rapid eye movement (REM) that alternate every 90 min with NREM preceding REM. Current findings indicate that the sleep-related epilepsy manifests predominantly during the synchronized stages of sleep; NREM over REM stage. Sleep related hypermotor epilepsy (SHE), benign partial epilepsy with centrotemporal spikes or benign rolandic epilepsy (BECTS), and Panayiotopoulos Syndrome (PS) are three of the most frequently implicated epilepsies occurring during the sleep state. Although some familial types are described, others are seemingly sporadic occurrences. In the present review, we aim to discuss the predominance of sleep-related epilepsy during NREM, established familial links to the pathogenesis of SHE, BECTS and PS, and highlight the present available pharmacotherapy options.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalFrontiers in Pharmacology
Volume9
DOIs
Publication statusPublished - 1 Sep 2018

Fingerprint

Epilepsy
Sleep
Rolandic Epilepsy
Drug Therapy
Eye Movements
REM Sleep
Partial Epilepsy
Sleep Stages
Seizures

Keywords

  • BECTS
  • Epilepsy
  • Panayiotopoulos
  • PS
  • Rolandic
  • Seizure
  • SHE
  • Sleep

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Sleep related epilepsy and pharmacotherapy : An insight. / Kumar, Jaya; Solaiman, Amro; Mahakkanukrauh, Pasuk; Pakri Mohamed, Rashidi Mohamed; Das, Srijit.

In: Frontiers in Pharmacology, Vol. 9, 01.09.2018, p. 1-17.

Research output: Contribution to journalReview article

Kumar, Jaya ; Solaiman, Amro ; Mahakkanukrauh, Pasuk ; Pakri Mohamed, Rashidi Mohamed ; Das, Srijit. / Sleep related epilepsy and pharmacotherapy : An insight. In: Frontiers in Pharmacology. 2018 ; Vol. 9. pp. 1-17.
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