Skin pH mapping and its relationship with transepidermal water loss, hydration and disease severity in adult patients with atopic dermatitis

Hazleen Zainal, Adawiyah Jamil, Norazirah Md Nor, Min Moon Tang

Research output: Contribution to journalArticle

Abstract

Background: Defective skin's acidic mantle is a component of atopic dermatitis (AD) pathophysiology. We mapped the skin pH and determine its relationship with transepidermal water loss (TEWL), hydration and disease severity. Materials and Methods: A cross-sectional study involving patients aged ≥18 years. Eczema Area and Severity Index (EASI) was assessed. Skin pH, TEWL and hydration were measured at 18 pre-determined sites. Results: Forty-eight patients participated, 33(68.8%) females and 15(31.3%) males aged 28.46 ± 12.07 years. The overall skin pH was 5.32 ± 0.68 ranging from 5.16 ± 0.75 to 5.52 ± 0.59. The lowest pH 5.16 ± 0.75 was at anterior leg, popliteal fossae 5.18 ± 0.67, lower back 5.21 ± 0.64, forehead 5.22 ± 0.62, upper back 5.25 ± 0.65 and neck 5.26 ± 0.76. Highest pH was at the cheek 5.52 ± 0.59, anterior thigh 5.47 ± 0.68, dorsal arm 5.46 ± 0.68, volar arm 5.43 ± 0.67 and abdomen 5.39 ± 0.67. Lesional areas’ pH (5.40 ± 0.13) was higher than nonlesional (5.27 ± 0.14), P =.01. pH at AD predilection sites was significantly lower non-predilection sites (5.26 ± 0.59 vs 5.34 ± 0.64). pH did not correlate with TEWL (r =.23, P =.12), EASI (r =.19, P =.20) and itch (r =.06, P =.70) but correlated with hydration r = −.33, P =.02. Conclusion: Skin pH was lower at AD predilection sites. There was no correlation between pH with AD severity and TEWL, pH correlated with hydration.

Original languageEnglish
JournalSkin Research and Technology
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Fingerprint

Atopic Dermatitis
Skin
Water
Eczema
Arm
Forehead
Cheek
Thigh
Abdomen
Leg
Neck
Cross-Sectional Studies

Keywords

  • atopic dermatitis
  • eczema
  • hydration
  • pH
  • transepidermal water loss

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{1e0dbbb605d34a7da3543c8cf46e2e10,
title = "Skin pH mapping and its relationship with transepidermal water loss, hydration and disease severity in adult patients with atopic dermatitis",
abstract = "Background: Defective skin's acidic mantle is a component of atopic dermatitis (AD) pathophysiology. We mapped the skin pH and determine its relationship with transepidermal water loss (TEWL), hydration and disease severity. Materials and Methods: A cross-sectional study involving patients aged ≥18 years. Eczema Area and Severity Index (EASI) was assessed. Skin pH, TEWL and hydration were measured at 18 pre-determined sites. Results: Forty-eight patients participated, 33(68.8{\%}) females and 15(31.3{\%}) males aged 28.46 ± 12.07 years. The overall skin pH was 5.32 ± 0.68 ranging from 5.16 ± 0.75 to 5.52 ± 0.59. The lowest pH 5.16 ± 0.75 was at anterior leg, popliteal fossae 5.18 ± 0.67, lower back 5.21 ± 0.64, forehead 5.22 ± 0.62, upper back 5.25 ± 0.65 and neck 5.26 ± 0.76. Highest pH was at the cheek 5.52 ± 0.59, anterior thigh 5.47 ± 0.68, dorsal arm 5.46 ± 0.68, volar arm 5.43 ± 0.67 and abdomen 5.39 ± 0.67. Lesional areas’ pH (5.40 ± 0.13) was higher than nonlesional (5.27 ± 0.14), P =.01. pH at AD predilection sites was significantly lower non-predilection sites (5.26 ± 0.59 vs 5.34 ± 0.64). pH did not correlate with TEWL (r =.23, P =.12), EASI (r =.19, P =.20) and itch (r =.06, P =.70) but correlated with hydration r = −.33, P =.02. Conclusion: Skin pH was lower at AD predilection sites. There was no correlation between pH with AD severity and TEWL, pH correlated with hydration.",
keywords = "atopic dermatitis, eczema, hydration, pH, transepidermal water loss",
author = "Hazleen Zainal and Adawiyah Jamil and {Md Nor}, Norazirah and Tang, {Min Moon}",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/srt.12768",
language = "English",
journal = "Skin Research and Technology",
issn = "0909-752X",
publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Skin pH mapping and its relationship with transepidermal water loss, hydration and disease severity in adult patients with atopic dermatitis

AU - Zainal, Hazleen

AU - Jamil, Adawiyah

AU - Md Nor, Norazirah

AU - Tang, Min Moon

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Defective skin's acidic mantle is a component of atopic dermatitis (AD) pathophysiology. We mapped the skin pH and determine its relationship with transepidermal water loss (TEWL), hydration and disease severity. Materials and Methods: A cross-sectional study involving patients aged ≥18 years. Eczema Area and Severity Index (EASI) was assessed. Skin pH, TEWL and hydration were measured at 18 pre-determined sites. Results: Forty-eight patients participated, 33(68.8%) females and 15(31.3%) males aged 28.46 ± 12.07 years. The overall skin pH was 5.32 ± 0.68 ranging from 5.16 ± 0.75 to 5.52 ± 0.59. The lowest pH 5.16 ± 0.75 was at anterior leg, popliteal fossae 5.18 ± 0.67, lower back 5.21 ± 0.64, forehead 5.22 ± 0.62, upper back 5.25 ± 0.65 and neck 5.26 ± 0.76. Highest pH was at the cheek 5.52 ± 0.59, anterior thigh 5.47 ± 0.68, dorsal arm 5.46 ± 0.68, volar arm 5.43 ± 0.67 and abdomen 5.39 ± 0.67. Lesional areas’ pH (5.40 ± 0.13) was higher than nonlesional (5.27 ± 0.14), P =.01. pH at AD predilection sites was significantly lower non-predilection sites (5.26 ± 0.59 vs 5.34 ± 0.64). pH did not correlate with TEWL (r =.23, P =.12), EASI (r =.19, P =.20) and itch (r =.06, P =.70) but correlated with hydration r = −.33, P =.02. Conclusion: Skin pH was lower at AD predilection sites. There was no correlation between pH with AD severity and TEWL, pH correlated with hydration.

AB - Background: Defective skin's acidic mantle is a component of atopic dermatitis (AD) pathophysiology. We mapped the skin pH and determine its relationship with transepidermal water loss (TEWL), hydration and disease severity. Materials and Methods: A cross-sectional study involving patients aged ≥18 years. Eczema Area and Severity Index (EASI) was assessed. Skin pH, TEWL and hydration were measured at 18 pre-determined sites. Results: Forty-eight patients participated, 33(68.8%) females and 15(31.3%) males aged 28.46 ± 12.07 years. The overall skin pH was 5.32 ± 0.68 ranging from 5.16 ± 0.75 to 5.52 ± 0.59. The lowest pH 5.16 ± 0.75 was at anterior leg, popliteal fossae 5.18 ± 0.67, lower back 5.21 ± 0.64, forehead 5.22 ± 0.62, upper back 5.25 ± 0.65 and neck 5.26 ± 0.76. Highest pH was at the cheek 5.52 ± 0.59, anterior thigh 5.47 ± 0.68, dorsal arm 5.46 ± 0.68, volar arm 5.43 ± 0.67 and abdomen 5.39 ± 0.67. Lesional areas’ pH (5.40 ± 0.13) was higher than nonlesional (5.27 ± 0.14), P =.01. pH at AD predilection sites was significantly lower non-predilection sites (5.26 ± 0.59 vs 5.34 ± 0.64). pH did not correlate with TEWL (r =.23, P =.12), EASI (r =.19, P =.20) and itch (r =.06, P =.70) but correlated with hydration r = −.33, P =.02. Conclusion: Skin pH was lower at AD predilection sites. There was no correlation between pH with AD severity and TEWL, pH correlated with hydration.

KW - atopic dermatitis

KW - eczema

KW - hydration

KW - pH

KW - transepidermal water loss

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DO - 10.1111/srt.12768

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