Simvastatin-loaded lyophilized wafers as a potential dressing for chronic wounds

Masoud Rezvanian, Chin Khai Tan, Shiow Fern Ng

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Wafers are an established drug delivery system for application to suppurating wounds. They can absorb wound exudates and are converted into a gel, offering a moist environment that is vital for wound healing. Simvastatin-loaded lyophilized wafers were developed using sodium carboxymethyl cellulose (CMC) and methyl cellulose (MC) and evaluated for their potential in the management of chronic wounds. Simvastatin (SIM) was chosen as the model drug since it is known to accelerate wound healing by promoting angiogenesis and lymphangiogenesis. Pre-formulation studies were carried out with CMC, MC, and a mixture of CMC and MC. Wafers obtained from aqueous gels of 3% CMC and blend of CMC-MC in the % weight ratio of 2:1 and 1.5:1.5 were selected for further analysis. The formulated wafers were characterized by microscopic examination, texture analysis, hydration test, rheological studies, FTIR spectroscopy, water vapor transmission and drug release test. Among the selected formulations, simvastatin-loaded CMC-MC (2:1) wafers exhibited the most desired characteristics for wound dressing application, such as good flexibility, hardness, sponginess, and viscosity. It showed a sustained drug release, which is desirable in wound healing, and was more appropriate for suppurating wounds. In conclusion, simvastatin-loaded CMC-MC (2:1) wafers showing potential for wound dressing applications were successfully developed.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalDrug Development and Industrial Pharmacy
DOIs
Publication statusAccepted/In press - 24 Jun 2016

Fingerprint

Carboxymethylcellulose Sodium
Simvastatin
Bandages
Methylcellulose
Wounds and Injuries
Wound Healing
Gels
Pharmaceutical Preparations
Lymphangiogenesis
Steam
Hardness
Exudates and Transudates
Fourier Transform Infrared Spectroscopy
Drug Delivery Systems
Viscosity
Hydration
Spectrum Analysis
Microscopic examination
Textures
Sodium

Keywords

  • Carboxymethyl cellulose
  • lyophilized wafer
  • methyl cellulose
  • simvastatin
  • wound dressing

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry

Cite this

Simvastatin-loaded lyophilized wafers as a potential dressing for chronic wounds. / Rezvanian, Masoud; Tan, Chin Khai; Ng, Shiow Fern.

In: Drug Development and Industrial Pharmacy, 24.06.2016, p. 1-8.

Research output: Contribution to journalArticle

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