Significant health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy in Malaysia

Reena Rajasuriar, Meng Li Chong, Nor Syuhada Ahmad Bashah, Siti Azdiah Abdul Aziz, Megan Mcstea, Erica Chai Yong Lee, Pui Li Wong, Iskandar Azwa, Sharifah Faridah Syed Omar, Pauline Siew Mei Lai, Sasheela Ponampalavanar, Suzanne M. Crowe, Sharon R. Lewin, Shahrul Bahyah Kamaruzzaman, Adeeba Kamarulzaman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

BACKGROUND:: Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge however, studies assessing multidimensional aspects of aging are lacking. We characterised ten geriatric conditions (GCs) encompassing multiple functional domains, its health impact and associated risk factors in HIV-infected and age-matched uninfected controls. METHODS:: HIV-infected individuals were recruited from the out-patient clinic in University Malaya Medical Centre, Malaysia and controls from the community. All participants were aged ≥25years, no acute illness and HIV-infected individuals were on stable ART. GCs were assessed and the burden scored as a composite of GCs present in an individual (total score?=?10). Multivariate regression analysis was performed to determine the risk factors and health impact associated with the burden of GCs. RESULTS:: We analysed data from 336 HIV-infected individuals (total HIV+), of whom 172 were matched for age, gender and ethnicity with 172 HIV-uninfected controls (matched subset). In the total HIV+ cohort, median (interquartile range) age was 44 (38–51)years and CD4 T-cell count was 562 (398–737)cells/μl. The burden of GCs was significantly higher in the HIV-infected group compared to controls (p?<?0.001). With an increasing GC burden, quality of life scores were 2.2-times poorer, health-care utilisation 5-times greater and mortality risk scores 4-times higher in the HIV-infected group compared to matched controls. Both socio-behavioural and HIV-related clinical factors were independently associated with an increasing burden of GC in HIV. CONCLUSIONS:: A high burden of GCs with significant impact on health outcomes, including mortality risk scores are observed among HIV-infected individuals on ART in a resource-limited setting.

Original languageEnglish
JournalAIDS
DOIs
Publication statusAccepted/In press - 29 Mar 2017

Fingerprint

Malaysia
HIV
Geriatrics
Health
Therapeutics
Patient Acceptance of Health Care
Mortality
CD4 Lymphocyte Count
Outpatients
Multivariate Analysis
Regression Analysis
Quality of Life

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Rajasuriar, R., Chong, M. L., Ahmad Bashah, N. S., Abdul Aziz, S. A., Mcstea, M., Lee, E. C. Y., ... Kamarulzaman, A. (Accepted/In press). Significant health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy in Malaysia. AIDS. https://doi.org/10.1097/QAD.0000000000001475

Significant health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy in Malaysia. / Rajasuriar, Reena; Chong, Meng Li; Ahmad Bashah, Nor Syuhada; Abdul Aziz, Siti Azdiah; Mcstea, Megan; Lee, Erica Chai Yong; Wong, Pui Li; Azwa, Iskandar; Syed Omar, Sharifah Faridah; Lai, Pauline Siew Mei; Ponampalavanar, Sasheela; Crowe, Suzanne M.; Lewin, Sharon R.; Kamaruzzaman, Shahrul Bahyah; Kamarulzaman, Adeeba.

In: AIDS, 29.03.2017.

Research output: Contribution to journalArticle

Rajasuriar, R, Chong, ML, Ahmad Bashah, NS, Abdul Aziz, SA, Mcstea, M, Lee, ECY, Wong, PL, Azwa, I, Syed Omar, SF, Lai, PSM, Ponampalavanar, S, Crowe, SM, Lewin, SR, Kamaruzzaman, SB & Kamarulzaman, A 2017, 'Significant health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy in Malaysia', AIDS. https://doi.org/10.1097/QAD.0000000000001475
Rajasuriar, Reena ; Chong, Meng Li ; Ahmad Bashah, Nor Syuhada ; Abdul Aziz, Siti Azdiah ; Mcstea, Megan ; Lee, Erica Chai Yong ; Wong, Pui Li ; Azwa, Iskandar ; Syed Omar, Sharifah Faridah ; Lai, Pauline Siew Mei ; Ponampalavanar, Sasheela ; Crowe, Suzanne M. ; Lewin, Sharon R. ; Kamaruzzaman, Shahrul Bahyah ; Kamarulzaman, Adeeba. / Significant health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy in Malaysia. In: AIDS. 2017.
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abstract = "BACKGROUND:: Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge however, studies assessing multidimensional aspects of aging are lacking. We characterised ten geriatric conditions (GCs) encompassing multiple functional domains, its health impact and associated risk factors in HIV-infected and age-matched uninfected controls. METHODS:: HIV-infected individuals were recruited from the out-patient clinic in University Malaya Medical Centre, Malaysia and controls from the community. All participants were aged ≥25years, no acute illness and HIV-infected individuals were on stable ART. GCs were assessed and the burden scored as a composite of GCs present in an individual (total score?=?10). Multivariate regression analysis was performed to determine the risk factors and health impact associated with the burden of GCs. RESULTS:: We analysed data from 336 HIV-infected individuals (total HIV+), of whom 172 were matched for age, gender and ethnicity with 172 HIV-uninfected controls (matched subset). In the total HIV+ cohort, median (interquartile range) age was 44 (38–51)years and CD4 T-cell count was 562 (398–737)cells/μl. The burden of GCs was significantly higher in the HIV-infected group compared to controls (p?<?0.001). With an increasing GC burden, quality of life scores were 2.2-times poorer, health-care utilisation 5-times greater and mortality risk scores 4-times higher in the HIV-infected group compared to matched controls. Both socio-behavioural and HIV-related clinical factors were independently associated with an increasing burden of GC in HIV. CONCLUSIONS:: A high burden of GCs with significant impact on health outcomes, including mortality risk scores are observed among HIV-infected individuals on ART in a resource-limited setting.",
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AU - Chong, Meng Li

AU - Ahmad Bashah, Nor Syuhada

AU - Abdul Aziz, Siti Azdiah

AU - Mcstea, Megan

AU - Lee, Erica Chai Yong

AU - Wong, Pui Li

AU - Azwa, Iskandar

AU - Syed Omar, Sharifah Faridah

AU - Lai, Pauline Siew Mei

AU - Ponampalavanar, Sasheela

AU - Crowe, Suzanne M.

AU - Lewin, Sharon R.

AU - Kamaruzzaman, Shahrul Bahyah

AU - Kamarulzaman, Adeeba

PY - 2017/3/29

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N2 - BACKGROUND:: Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge however, studies assessing multidimensional aspects of aging are lacking. We characterised ten geriatric conditions (GCs) encompassing multiple functional domains, its health impact and associated risk factors in HIV-infected and age-matched uninfected controls. METHODS:: HIV-infected individuals were recruited from the out-patient clinic in University Malaya Medical Centre, Malaysia and controls from the community. All participants were aged ≥25years, no acute illness and HIV-infected individuals were on stable ART. GCs were assessed and the burden scored as a composite of GCs present in an individual (total score?=?10). Multivariate regression analysis was performed to determine the risk factors and health impact associated with the burden of GCs. RESULTS:: We analysed data from 336 HIV-infected individuals (total HIV+), of whom 172 were matched for age, gender and ethnicity with 172 HIV-uninfected controls (matched subset). In the total HIV+ cohort, median (interquartile range) age was 44 (38–51)years and CD4 T-cell count was 562 (398–737)cells/μl. The burden of GCs was significantly higher in the HIV-infected group compared to controls (p?<?0.001). With an increasing GC burden, quality of life scores were 2.2-times poorer, health-care utilisation 5-times greater and mortality risk scores 4-times higher in the HIV-infected group compared to matched controls. Both socio-behavioural and HIV-related clinical factors were independently associated with an increasing burden of GC in HIV. CONCLUSIONS:: A high burden of GCs with significant impact on health outcomes, including mortality risk scores are observed among HIV-infected individuals on ART in a resource-limited setting.

AB - BACKGROUND:: Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge however, studies assessing multidimensional aspects of aging are lacking. We characterised ten geriatric conditions (GCs) encompassing multiple functional domains, its health impact and associated risk factors in HIV-infected and age-matched uninfected controls. METHODS:: HIV-infected individuals were recruited from the out-patient clinic in University Malaya Medical Centre, Malaysia and controls from the community. All participants were aged ≥25years, no acute illness and HIV-infected individuals were on stable ART. GCs were assessed and the burden scored as a composite of GCs present in an individual (total score?=?10). Multivariate regression analysis was performed to determine the risk factors and health impact associated with the burden of GCs. RESULTS:: We analysed data from 336 HIV-infected individuals (total HIV+), of whom 172 were matched for age, gender and ethnicity with 172 HIV-uninfected controls (matched subset). In the total HIV+ cohort, median (interquartile range) age was 44 (38–51)years and CD4 T-cell count was 562 (398–737)cells/μl. The burden of GCs was significantly higher in the HIV-infected group compared to controls (p?<?0.001). With an increasing GC burden, quality of life scores were 2.2-times poorer, health-care utilisation 5-times greater and mortality risk scores 4-times higher in the HIV-infected group compared to matched controls. Both socio-behavioural and HIV-related clinical factors were independently associated with an increasing burden of GC in HIV. CONCLUSIONS:: A high burden of GCs with significant impact on health outcomes, including mortality risk scores are observed among HIV-infected individuals on ART in a resource-limited setting.

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