Significant association between parathyroid hormone and uric acid level in men

Chin Kok Yong, Ima Nirwana Soelaiman, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Previous reports of patients undergoing parathyroidectomy and of patients receiving teriparatide as antiosteoporotic treatment have suggested a plausible relationship between parathyroid hormone (PTH) and uric acid. However, similar data at population level were lacking. The current study aimed to determine the relationship between PTH and uric acid in a group of apparently healthy Malaysian men. Methods: A cross-sectional study was conducted among 380 Malay and Chinese men aged 20 years and above, residing in the Klang Valley, Malaysia. Their body anthropometry was measured, and their fasting blood samples were collected for biochemical analysis. The relationship between PTH and uric acid was analyzed using regression analysis. Results: Increased serum PTH level was significantly associated with increased serum uric acid level (β=0.165; P=0.001). Increased PTH level was also significantly associated with the condition of hyperuricemia in the study population (odds ratio [OR], 1.045; 95% confidence interval [CI], 1.017–1.075; P=0.002). All analyses were adjusted for age, body mass index, vitamin D, total calcium, inorganic phosphate, blood urea nitrogen and creatinine levels. Conclusion: There is a significant positive relationship between PTH level and uric acid level in Malaysian men. This relationship and its clinical significance should be further investigated in a larger longitudinal study.

Original languageEnglish
Pages (from-to)1377-1380
Number of pages4
JournalClinical Interventions in Aging
Volume10
DOIs
Publication statusPublished - 21 Aug 2015

Fingerprint

Uric Acid
Parathyroid Hormone
Teriparatide
Hyperuricemia
Parathyroidectomy
Anthropometry
Blood Urea Nitrogen
Malaysia
Serum
Vitamin D
Population
Longitudinal Studies
Fasting
Creatinine
Body Mass Index
Cross-Sectional Studies
Odds Ratio
Regression Analysis
Confidence Intervals

Keywords

  • Asian
  • Cross-sectional study
  • Hyperuricemia
  • Urate
  • Uric acid

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Significant association between parathyroid hormone and uric acid level in men. / Kok Yong, Chin; Soelaiman, Ima Nirwana; Ngah, Wan Zurinah Wan.

In: Clinical Interventions in Aging, Vol. 10, 21.08.2015, p. 1377-1380.

Research output: Contribution to journalArticle

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