Signatures of gene expression, DNA methylation and microRNAs of hepatocellular carcinoma with vascular invasion

Siti A. Sulaiman, Nadiah Abu, Nurul Syakima Ab-Mutalib, Low Teck Yew, A. Rahman A. Jamal

Research output: Contribution to journalArticle

Abstract

Aim: Micro and macro vascular invasion (VI) are known as independent predictors of tumor recurrence and poor survival after surgical treatment of hepatocellular carcinoma (HCC). Here, we aimed to re-analyze The Cancer Genome Atlas of liver hepatocellular carcinoma datasets to identify the VI-expression signatures. Materials & methods: We filtered The Cancer Genome Atlas liver hepatocellular carcinoma (LIHC) datasets into three groups: no VI (NVI = 198); micro VI (MIVI = 89) and macro VI (MAVI = 16). We performed differential gene expression, methylation and microRNA analyses. Results & conclusion: We identified 12 differentially expressed genes and 55 differentially methylated genes in MAVI compared with no VI. The GPD1L gene appeared in all of the comparative analyses. Higher GPD1L expression was associated with VI and poor outcomes in the HCC patients.

Original languageEnglish
Pages (from-to)2603-2617
Number of pages15
JournalFuture Oncology
Volume15
Issue number22
DOIs
Publication statusPublished - 1 Aug 2019

Fingerprint

DNA Methylation
MicroRNAs
Transcriptome
Blood Vessels
Hepatocellular Carcinoma
Atlases
Genome
Genes
Neoplasms
Liver
Methylation
Gene Expression
Recurrence
Survival

Keywords

  • biomarker
  • GPD1L
  • HCC
  • TCGA
  • vascular invasion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Signatures of gene expression, DNA methylation and microRNAs of hepatocellular carcinoma with vascular invasion. / Sulaiman, Siti A.; Abu, Nadiah; Ab-Mutalib, Nurul Syakima; Teck Yew, Low; A. Jamal, A. Rahman.

In: Future Oncology, Vol. 15, No. 22, 01.08.2019, p. 2603-2617.

Research output: Contribution to journalArticle

@article{bd15f08e7e0041c6bceb5a9938295fcf,
title = "Signatures of gene expression, DNA methylation and microRNAs of hepatocellular carcinoma with vascular invasion",
abstract = "Aim: Micro and macro vascular invasion (VI) are known as independent predictors of tumor recurrence and poor survival after surgical treatment of hepatocellular carcinoma (HCC). Here, we aimed to re-analyze The Cancer Genome Atlas of liver hepatocellular carcinoma datasets to identify the VI-expression signatures. Materials & methods: We filtered The Cancer Genome Atlas liver hepatocellular carcinoma (LIHC) datasets into three groups: no VI (NVI = 198); micro VI (MIVI = 89) and macro VI (MAVI = 16). We performed differential gene expression, methylation and microRNA analyses. Results & conclusion: We identified 12 differentially expressed genes and 55 differentially methylated genes in MAVI compared with no VI. The GPD1L gene appeared in all of the comparative analyses. Higher GPD1L expression was associated with VI and poor outcomes in the HCC patients.",
keywords = "biomarker, GPD1L, HCC, TCGA, vascular invasion",
author = "Sulaiman, {Siti A.} and Nadiah Abu and Ab-Mutalib, {Nurul Syakima} and {Teck Yew}, Low and {A. Jamal}, {A. Rahman}",
year = "2019",
month = "8",
day = "1",
doi = "10.2217/fon-2018-0909",
language = "English",
volume = "15",
pages = "2603--2617",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "22",

}

TY - JOUR

T1 - Signatures of gene expression, DNA methylation and microRNAs of hepatocellular carcinoma with vascular invasion

AU - Sulaiman, Siti A.

AU - Abu, Nadiah

AU - Ab-Mutalib, Nurul Syakima

AU - Teck Yew, Low

AU - A. Jamal, A. Rahman

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Aim: Micro and macro vascular invasion (VI) are known as independent predictors of tumor recurrence and poor survival after surgical treatment of hepatocellular carcinoma (HCC). Here, we aimed to re-analyze The Cancer Genome Atlas of liver hepatocellular carcinoma datasets to identify the VI-expression signatures. Materials & methods: We filtered The Cancer Genome Atlas liver hepatocellular carcinoma (LIHC) datasets into three groups: no VI (NVI = 198); micro VI (MIVI = 89) and macro VI (MAVI = 16). We performed differential gene expression, methylation and microRNA analyses. Results & conclusion: We identified 12 differentially expressed genes and 55 differentially methylated genes in MAVI compared with no VI. The GPD1L gene appeared in all of the comparative analyses. Higher GPD1L expression was associated with VI and poor outcomes in the HCC patients.

AB - Aim: Micro and macro vascular invasion (VI) are known as independent predictors of tumor recurrence and poor survival after surgical treatment of hepatocellular carcinoma (HCC). Here, we aimed to re-analyze The Cancer Genome Atlas of liver hepatocellular carcinoma datasets to identify the VI-expression signatures. Materials & methods: We filtered The Cancer Genome Atlas liver hepatocellular carcinoma (LIHC) datasets into three groups: no VI (NVI = 198); micro VI (MIVI = 89) and macro VI (MAVI = 16). We performed differential gene expression, methylation and microRNA analyses. Results & conclusion: We identified 12 differentially expressed genes and 55 differentially methylated genes in MAVI compared with no VI. The GPD1L gene appeared in all of the comparative analyses. Higher GPD1L expression was associated with VI and poor outcomes in the HCC patients.

KW - biomarker

KW - GPD1L

KW - HCC

KW - TCGA

KW - vascular invasion

UR - http://www.scopus.com/inward/record.url?scp=85070840925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070840925&partnerID=8YFLogxK

U2 - 10.2217/fon-2018-0909

DO - 10.2217/fon-2018-0909

M3 - Article

C2 - 31339048

AN - SCOPUS:85070840925

VL - 15

SP - 2603

EP - 2617

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 22

ER -