Sexual arousal difficulties in women treated with antidepressants

A comparison between escitalopram and fluoxetine

Marhani Midi, Sharmilla Kanagasundram, Hatta Sidi, Duni Asmidar, Ling Naing, Ng Guan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To compare the risk of sexual arousal difficulties between two groups of depressed female patients in remission who were treated with either escitalopram or fluoxetine. Associated factors were also examined. Methods: This was a cross-sectional study involving 112 female patients attending the psychiatric clinic, University Kebangsaan Malaysia Medical Centre (UKMMC) with depressive disorders as assessed by using the Structured Clinical Interview for DSM-IV (SCID), who had been in remission for the previous 2 months as defined by a score of ≤10 from an assessment using the Montgomery-Asberg Depression Rating Scale (MADRS) and were treated with either fluoxetine or escitalopram. Sexual arousal difficulties were assessed using the arousal subscale of Malay Version of the Female Sexual Function Index (MVFSFI). Results: The rate of sexual arousal difficulties was 41.1% for all subjects. Sexual arousal difficulties occurred in 50.0% of subjects treated with fluoxetine and 32.1% with escitalopram. However, this difference was not statistically significant (p = 0.055). Multivariate logistic regression analysis showed that higher dose of antidepressant (adjusted OR = 4.08, 95 CI = 1.70-9.81) was significantly associated with female sexual arousal difficulties. Conclusion: The risk of sexual arousal difficulties was higher in female patients who were treated with higher doses of either fluoxetine or escitalopram.

Original languageEnglish
Pages (from-to)405-418
Number of pages14
JournalInternational Journal of Psychiatry in Medicine
Volume43
Issue number4
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Fingerprint

Citalopram
Fluoxetine
Arousal
Antidepressive Agents
Malaysia
Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Cross-Sectional Studies
Logistic Models
Regression Analysis
Interviews
Depression

Keywords

  • Depression
  • escitalopram
  • Female sexual arousal
  • Fluoxetine
  • Malaysia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Sexual arousal difficulties in women treated with antidepressants : A comparison between escitalopram and fluoxetine. / Midi, Marhani; Kanagasundram, Sharmilla; Sidi, Hatta; Asmidar, Duni; Naing, Ling; Guan, Ng.

In: International Journal of Psychiatry in Medicine, Vol. 43, No. 4, 01.01.2012, p. 405-418.

Research output: Contribution to journalArticle

Midi, Marhani ; Kanagasundram, Sharmilla ; Sidi, Hatta ; Asmidar, Duni ; Naing, Ling ; Guan, Ng. / Sexual arousal difficulties in women treated with antidepressants : A comparison between escitalopram and fluoxetine. In: International Journal of Psychiatry in Medicine. 2012 ; Vol. 43, No. 4. pp. 405-418.
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