Sex steroids and bone health status in men

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Male osteoporosis is a health problem which deserves more attention as nearly 30 of osteoporotic fractures happen in men aged 50 years and above. Although men do not experience an accelerated bone loss phase and testosterone deficiency is not a universal characteristic for aged men, osteoporosis due to age-related testosterone deficiency does have a negative impact on bone health status of men. Observations from epidemiological studies indicate that elderly men with higher testosterone can preserve their BMD better and thus are less prone to fracture. Observations on men with estrogen resistance or aromatase deficiency indicate that estrogen is equally important in the maintenance of bone health status. This had been validated in several epidemiological studies which found that the relationships between estrogen and bone health indices are significant and sometimes stronger than testosterone. Studies on the relationship between quantitative ultrasound and bone remodeling markers suggest that testosterone and estrogen may have differential effects on bone, but further evidence was needed. In conclusion, both testosterone and estrogen are important in the maintenance of bone health in men.

Original languageEnglish
Article number208719
JournalInternational Journal of Endocrinology
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Health Status
Testosterone
Steroids
Estrogens
Bone and Bones
Osteoporosis
Epidemiologic Studies
Maintenance
Men's Health
Osteoporotic Fractures
Bone Remodeling
Health

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Sex steroids and bone health status in men. / Kok Yong, Chin; Soelaiman, Ima Nirwana.

In: International Journal of Endocrinology, Vol. 2012, 208719, 2012.

Research output: Contribution to journalArticle

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