Sex differences in stroke incidence, prevalence,mortality and disability-adjusted life years: Results from the global burden of disease study 2013

GBD 2013 Writing Group and GBD 2013, Stroke Panel Experts Group

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Background: Accurate information on stroke burden in men and women are important for evidence-based healthcare planning and resource allocation. Previously, limited research suggested that the absolute number of deaths from stroke in women was greater than in men, but the incidence and mortality rates were greater in men. However, sex differences in various metrics of stroke burden on a global scale have not been a subject of comprehensive and comparable assessment for most regions of the world, nor have sex differences in stroke burden been examined for trends over time. Methods: Stroke incidence, prevalence, mortality, disability-adjusted life years (DALYs) and healthy years lost due to disability were estimated as part of the Global Burden of Disease (GBD) 2013 Study. Data inputs included all available information on stroke incidence, prevalence and death and case fatality rates. Analysis was performed separately by sex and 5-year age categories for 188 countries. Statistical models were employed to produce globally comprehensive results over time. All rates were age-standardized to a global population and 95% uncertainty intervals (UIs) were computed. Findings: In 2013, global ischemic stroke (IS) and hemorrhagic stroke (HS) incidence (per 100,000) in men (IS 132.77 (95% UI 125.34-142.77); HS 64.89 (95% UI 59.82-68.85)) exceeded those of women (IS 98.85 (95% UI 92.11-106.62); HS 45.48 (95% UI 42.43-48.53)). IS incidence rates were lower in 2013 compared with 1990 rates for both sexes (1990 male IS incidence 147.40 (95% UI 137.87-157.66); 1990 female IS incidence 113.31 (95% UI 103.52-123.40)), but the only significant change in IS incidence was among women.

Original languageEnglish
Pages (from-to)203-214
Number of pages12
JournalNeuroepidemiology
Volume45
Issue number3
DOIs
Publication statusPublished - 1 Oct 2015

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Quality-Adjusted Life Years
Sex Characteristics
Stroke
Mortality
Incidence
Uncertainty
Global Burden of Disease
Resource Allocation
Evidence-Based Practice
Statistical Models

Keywords

  • Burden
  • Epidemiology
  • Global
  • Sex differences
  • Stroke

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Sex differences in stroke incidence, prevalence,mortality and disability-adjusted life years : Results from the global burden of disease study 2013. / GBD 2013 Writing Group and GBD 2013; Stroke Panel Experts Group.

In: Neuroepidemiology, Vol. 45, No. 3, 01.10.2015, p. 203-214.

Research output: Contribution to journalArticle

GBD 2013 Writing Group and GBD 2013 ; Stroke Panel Experts Group. / Sex differences in stroke incidence, prevalence,mortality and disability-adjusted life years : Results from the global burden of disease study 2013. In: Neuroepidemiology. 2015 ; Vol. 45, No. 3. pp. 203-214.
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abstract = "Background: Accurate information on stroke burden in men and women are important for evidence-based healthcare planning and resource allocation. Previously, limited research suggested that the absolute number of deaths from stroke in women was greater than in men, but the incidence and mortality rates were greater in men. However, sex differences in various metrics of stroke burden on a global scale have not been a subject of comprehensive and comparable assessment for most regions of the world, nor have sex differences in stroke burden been examined for trends over time. Methods: Stroke incidence, prevalence, mortality, disability-adjusted life years (DALYs) and healthy years lost due to disability were estimated as part of the Global Burden of Disease (GBD) 2013 Study. Data inputs included all available information on stroke incidence, prevalence and death and case fatality rates. Analysis was performed separately by sex and 5-year age categories for 188 countries. Statistical models were employed to produce globally comprehensive results over time. All rates were age-standardized to a global population and 95{\%} uncertainty intervals (UIs) were computed. Findings: In 2013, global ischemic stroke (IS) and hemorrhagic stroke (HS) incidence (per 100,000) in men (IS 132.77 (95{\%} UI 125.34-142.77); HS 64.89 (95{\%} UI 59.82-68.85)) exceeded those of women (IS 98.85 (95{\%} UI 92.11-106.62); HS 45.48 (95{\%} UI 42.43-48.53)). IS incidence rates were lower in 2013 compared with 1990 rates for both sexes (1990 male IS incidence 147.40 (95{\%} UI 137.87-157.66); 1990 female IS incidence 113.31 (95{\%} UI 103.52-123.40)), but the only significant change in IS incidence was among women.",
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TY - JOUR

T1 - Sex differences in stroke incidence, prevalence,mortality and disability-adjusted life years

T2 - Results from the global burden of disease study 2013

AU - GBD 2013 Writing Group and GBD 2013

AU - Stroke Panel Experts Group

AU - Barker-Collo, Suzanne

AU - Bennett, Derrick A.

AU - Krishnamurthi, Rita V.

AU - Parmar, Priya

AU - Feigin, Valery L.

AU - Naghavi, Mohsen

AU - Forouzanfar, Mohammed H.

AU - Johnson, Catherine O.

AU - Nguyen, Grant

AU - Mensah, George A.

AU - Vos, Theo

AU - Murray, Christopher J L

AU - Roth, Gregory A.

AU - Abd-Allah, Foad

AU - Abera, Semaw Ferede

AU - Akinyemi, Rufus Olusola

AU - Bahit, Maria Cecilia

AU - Banerjee, Amitava

AU - Basu, Sanjay

AU - Brainin, Michael

AU - Bornstein, Natan M.

AU - Caso, Valeria

AU - Catalá-López, Ferrán

AU - Chowdhury, Rajiv

AU - Christensen, Hanne K.

AU - Colomar, Mercedes

AU - Davis, Stephen

AU - Deveber, Gabrielle

AU - Dharmaratne, Samath D.

AU - Donnan, Geoffrey

AU - Dorairaj, Prabhakaran

AU - Dokova, Klara

AU - Endres, Matthias

AU - Fernandes, Jefferson Gomes

AU - Geleijnse, Johanna M.

AU - Gillum, Richard F.

AU - Giroud, Maurice

AU - Hamadeh, Randah R.

AU - Hankey, Graeme J.

AU - Jeemon, Panniyammakal

AU - Jiang, Guohong

AU - Jonas, Jost B.

AU - Kalkonde, Yogesh

AU - Kengne, Andre Pascal

AU - Kim, Daniel

AU - Kissela, Brett M.

AU - Kokubo, Yoshihiro

AU - Lavados, Pablo M.

AU - Patrice Lindsay, M.

AU - Sahathevan, Ramesh

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background: Accurate information on stroke burden in men and women are important for evidence-based healthcare planning and resource allocation. Previously, limited research suggested that the absolute number of deaths from stroke in women was greater than in men, but the incidence and mortality rates were greater in men. However, sex differences in various metrics of stroke burden on a global scale have not been a subject of comprehensive and comparable assessment for most regions of the world, nor have sex differences in stroke burden been examined for trends over time. Methods: Stroke incidence, prevalence, mortality, disability-adjusted life years (DALYs) and healthy years lost due to disability were estimated as part of the Global Burden of Disease (GBD) 2013 Study. Data inputs included all available information on stroke incidence, prevalence and death and case fatality rates. Analysis was performed separately by sex and 5-year age categories for 188 countries. Statistical models were employed to produce globally comprehensive results over time. All rates were age-standardized to a global population and 95% uncertainty intervals (UIs) were computed. Findings: In 2013, global ischemic stroke (IS) and hemorrhagic stroke (HS) incidence (per 100,000) in men (IS 132.77 (95% UI 125.34-142.77); HS 64.89 (95% UI 59.82-68.85)) exceeded those of women (IS 98.85 (95% UI 92.11-106.62); HS 45.48 (95% UI 42.43-48.53)). IS incidence rates were lower in 2013 compared with 1990 rates for both sexes (1990 male IS incidence 147.40 (95% UI 137.87-157.66); 1990 female IS incidence 113.31 (95% UI 103.52-123.40)), but the only significant change in IS incidence was among women.

AB - Background: Accurate information on stroke burden in men and women are important for evidence-based healthcare planning and resource allocation. Previously, limited research suggested that the absolute number of deaths from stroke in women was greater than in men, but the incidence and mortality rates were greater in men. However, sex differences in various metrics of stroke burden on a global scale have not been a subject of comprehensive and comparable assessment for most regions of the world, nor have sex differences in stroke burden been examined for trends over time. Methods: Stroke incidence, prevalence, mortality, disability-adjusted life years (DALYs) and healthy years lost due to disability were estimated as part of the Global Burden of Disease (GBD) 2013 Study. Data inputs included all available information on stroke incidence, prevalence and death and case fatality rates. Analysis was performed separately by sex and 5-year age categories for 188 countries. Statistical models were employed to produce globally comprehensive results over time. All rates were age-standardized to a global population and 95% uncertainty intervals (UIs) were computed. Findings: In 2013, global ischemic stroke (IS) and hemorrhagic stroke (HS) incidence (per 100,000) in men (IS 132.77 (95% UI 125.34-142.77); HS 64.89 (95% UI 59.82-68.85)) exceeded those of women (IS 98.85 (95% UI 92.11-106.62); HS 45.48 (95% UI 42.43-48.53)). IS incidence rates were lower in 2013 compared with 1990 rates for both sexes (1990 male IS incidence 147.40 (95% UI 137.87-157.66); 1990 female IS incidence 113.31 (95% UI 103.52-123.40)), but the only significant change in IS incidence was among women.

KW - Burden

KW - Epidemiology

KW - Global

KW - Sex differences

KW - Stroke

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