Serum selenium level and other risk factors for breast cancer among patients in a Malaysian hospital

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The aim of this study is to investigate the association between breast cancer and serum selenium level as well as other risk factors for breast cancer. Methods: A matched case-control study was conducted in a hospital in Malaysia from July 2000 to January 2001 and from May 2001 to June 2001. Sixty-two newly diagnosed breast cancer patients were selected as the cases. Each control, selected from the same hospital population was matched to each case according to age, ethnic group, and menopausal status. Results: The mean selenium concentration among the cases was significantly lower than that among the control. There was a significant association (p<0.05) between breast cancer and low selenium serum level, nulliparity (OR=5.5, 95% CI=1.22 to 24.81), exposure to cigarette smoke (OR=2.2, 95% CI=1.04 to 4.65) and use of oral contraceptives (OR=3.0, 95% CI=1.09 to 8.25) as determined by the McNemar test. Multivariate analysis showed that nulliparity (OR=10.08, 95% CI=1.48 to 68.52) and use of oral contraceptives (OR=3.66, 95% CI=1.36 to 9.87) were associated with increased breast cancer risk. An increased selenium concentration contributes to a reduced risk of breast cancer (OR=0.89, 95% CI=0.84 to 0.94). Conclusion: The results suggest that use of oral contraceptive pills, being nulliparous, and a low serum selenium level are associated with breast cancer.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalEnvironmental Health and Preventive Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - 2007

Fingerprint

Selenium
Breast Neoplasms
Serum
Oral Contraceptives
Parity
Smoke
Malaysia
Ethnic Groups
Tobacco Products
Case-Control Studies
Multivariate Analysis
Age Groups
Population

Keywords

  • Breast cancer
  • Glutathione peroxides enzyme
  • Nulliparity
  • Oral contraceptives
  • Selenium

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Pollution

Cite this

@article{2143185d5c3943a3a389edcbef6ff99d,
title = "Serum selenium level and other risk factors for breast cancer among patients in a Malaysian hospital",
abstract = "Objective: The aim of this study is to investigate the association between breast cancer and serum selenium level as well as other risk factors for breast cancer. Methods: A matched case-control study was conducted in a hospital in Malaysia from July 2000 to January 2001 and from May 2001 to June 2001. Sixty-two newly diagnosed breast cancer patients were selected as the cases. Each control, selected from the same hospital population was matched to each case according to age, ethnic group, and menopausal status. Results: The mean selenium concentration among the cases was significantly lower than that among the control. There was a significant association (p<0.05) between breast cancer and low selenium serum level, nulliparity (OR=5.5, 95{\%} CI=1.22 to 24.81), exposure to cigarette smoke (OR=2.2, 95{\%} CI=1.04 to 4.65) and use of oral contraceptives (OR=3.0, 95{\%} CI=1.09 to 8.25) as determined by the McNemar test. Multivariate analysis showed that nulliparity (OR=10.08, 95{\%} CI=1.48 to 68.52) and use of oral contraceptives (OR=3.66, 95{\%} CI=1.36 to 9.87) were associated with increased breast cancer risk. An increased selenium concentration contributes to a reduced risk of breast cancer (OR=0.89, 95{\%} CI=0.84 to 0.94). Conclusion: The results suggest that use of oral contraceptive pills, being nulliparous, and a low serum selenium level are associated with breast cancer.",
keywords = "Breast cancer, Glutathione peroxides enzyme, Nulliparity, Oral contraceptives, Selenium",
author = "Lokman Rejali and Ja`Afar, {Mohd Hasni} and Ismail, {Noor Hassim}",
year = "2007",
doi = "10.1265/ehpm.12.105",
language = "English",
volume = "12",
pages = "105--110",
journal = "Environmental Health and Preventive Medicine",
issn = "1342-078X",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Serum selenium level and other risk factors for breast cancer among patients in a Malaysian hospital

AU - Rejali, Lokman

AU - Ja`Afar, Mohd Hasni

AU - Ismail, Noor Hassim

PY - 2007

Y1 - 2007

N2 - Objective: The aim of this study is to investigate the association between breast cancer and serum selenium level as well as other risk factors for breast cancer. Methods: A matched case-control study was conducted in a hospital in Malaysia from July 2000 to January 2001 and from May 2001 to June 2001. Sixty-two newly diagnosed breast cancer patients were selected as the cases. Each control, selected from the same hospital population was matched to each case according to age, ethnic group, and menopausal status. Results: The mean selenium concentration among the cases was significantly lower than that among the control. There was a significant association (p<0.05) between breast cancer and low selenium serum level, nulliparity (OR=5.5, 95% CI=1.22 to 24.81), exposure to cigarette smoke (OR=2.2, 95% CI=1.04 to 4.65) and use of oral contraceptives (OR=3.0, 95% CI=1.09 to 8.25) as determined by the McNemar test. Multivariate analysis showed that nulliparity (OR=10.08, 95% CI=1.48 to 68.52) and use of oral contraceptives (OR=3.66, 95% CI=1.36 to 9.87) were associated with increased breast cancer risk. An increased selenium concentration contributes to a reduced risk of breast cancer (OR=0.89, 95% CI=0.84 to 0.94). Conclusion: The results suggest that use of oral contraceptive pills, being nulliparous, and a low serum selenium level are associated with breast cancer.

AB - Objective: The aim of this study is to investigate the association between breast cancer and serum selenium level as well as other risk factors for breast cancer. Methods: A matched case-control study was conducted in a hospital in Malaysia from July 2000 to January 2001 and from May 2001 to June 2001. Sixty-two newly diagnosed breast cancer patients were selected as the cases. Each control, selected from the same hospital population was matched to each case according to age, ethnic group, and menopausal status. Results: The mean selenium concentration among the cases was significantly lower than that among the control. There was a significant association (p<0.05) between breast cancer and low selenium serum level, nulliparity (OR=5.5, 95% CI=1.22 to 24.81), exposure to cigarette smoke (OR=2.2, 95% CI=1.04 to 4.65) and use of oral contraceptives (OR=3.0, 95% CI=1.09 to 8.25) as determined by the McNemar test. Multivariate analysis showed that nulliparity (OR=10.08, 95% CI=1.48 to 68.52) and use of oral contraceptives (OR=3.66, 95% CI=1.36 to 9.87) were associated with increased breast cancer risk. An increased selenium concentration contributes to a reduced risk of breast cancer (OR=0.89, 95% CI=0.84 to 0.94). Conclusion: The results suggest that use of oral contraceptive pills, being nulliparous, and a low serum selenium level are associated with breast cancer.

KW - Breast cancer

KW - Glutathione peroxides enzyme

KW - Nulliparity

KW - Oral contraceptives

KW - Selenium

UR - http://www.scopus.com/inward/record.url?scp=34250186110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250186110&partnerID=8YFLogxK

U2 - 10.1265/ehpm.12.105

DO - 10.1265/ehpm.12.105

M3 - Article

C2 - 21432063

AN - SCOPUS:34250186110

VL - 12

SP - 105

EP - 110

JO - Environmental Health and Preventive Medicine

JF - Environmental Health and Preventive Medicine

SN - 1342-078X

IS - 3

ER -