Serum osteocalcin in subjects with metabolic syndrome and central obesity

Khalidah Adibah Mazlan, Lim D. Wee, Siti Aizon A. Halim, Mohd Faris M. Fadi, Premalatha Santhiran, Nabila F. Rosli, Norlaila Mustafa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims The aim of this study was to determine if osteocalcin is related to adiposity and hyperglycaemia in metabolic syndrome irrespective of the presence of diabetes mellitus. Materials and Methods This was a cross sectional study of 90 patients (59 men and 31 women) with metabolic syndrome as defined by the International Diabetes Federation criteria. Based on medical history 50 out of 90 patients had a diabetes. Anthropometric data were collected and blood taken for measurement of osteocalcin, fasting lipids, fasting glucose and insulin resistance (using homeostatic model assessment index, HOMA-IR). Results Osteocalcin correlated negatively with fasting glucose (r = −0.366, p < 0.001) and HOMA-IR (r = −0.305, p < 0.05) but not with waist circumference (r = 0.079), body mass index (r = 0.028), total cholesterol (r = 0.061) or triglycerides (r = 0.009). Diabetics had higher HOMA-IR (p < 0.01) and lower osteocalcin levels (p < 0.01) than non-diabetics. Among diabetics, osteocalcin correlated with glucose only (r = −0.341, p = 0.015). In non-diabetics, osteocalcin correlated with HOMA-IR (r = −0.359, p = 0.023) via insulin (r = −0.402, p = 0.010). Patients with impaired fasting glucose levels (5.6–6.9 mmol/L) had the same HOMA-IR as diabetics (p = 0.076) but not low osteocalcin (p = 0.025). Conclusions In this cross-sectional study of subjects with metabolic syndrome and central obesity, low osteocalcin was associated with diabetes but not adiposity.

Original languageEnglish
Pages (from-to)S42-S45
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume10
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Abdominal Obesity
Osteocalcin
Serum
Fasting
Glucose
Adiposity
Cross-Sectional Studies
Waist Circumference
Hyperglycemia
Insulin Resistance
Diabetes Mellitus
Triglycerides
Body Mass Index
Cholesterol
Insulin
Lipids

Keywords

  • Adiposity
  • Central obesity
  • Diabetes
  • Metabolic syndrome
  • Osteocalcin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum osteocalcin in subjects with metabolic syndrome and central obesity. / Mazlan, Khalidah Adibah; Wee, Lim D.; Halim, Siti Aizon A.; Fadi, Mohd Faris M.; Santhiran, Premalatha; Rosli, Nabila F.; Mustafa, Norlaila.

In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, Vol. 10, No. 1, 2016, p. S42-S45.

Research output: Contribution to journalArticle

Mazlan, Khalidah Adibah ; Wee, Lim D. ; Halim, Siti Aizon A. ; Fadi, Mohd Faris M. ; Santhiran, Premalatha ; Rosli, Nabila F. ; Mustafa, Norlaila. / Serum osteocalcin in subjects with metabolic syndrome and central obesity. In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2016 ; Vol. 10, No. 1. pp. S42-S45.
@article{b2e4b8316dc44a98b1243739d7d088ce,
title = "Serum osteocalcin in subjects with metabolic syndrome and central obesity",
abstract = "Aims The aim of this study was to determine if osteocalcin is related to adiposity and hyperglycaemia in metabolic syndrome irrespective of the presence of diabetes mellitus. Materials and Methods This was a cross sectional study of 90 patients (59 men and 31 women) with metabolic syndrome as defined by the International Diabetes Federation criteria. Based on medical history 50 out of 90 patients had a diabetes. Anthropometric data were collected and blood taken for measurement of osteocalcin, fasting lipids, fasting glucose and insulin resistance (using homeostatic model assessment index, HOMA-IR). Results Osteocalcin correlated negatively with fasting glucose (r = −0.366, p < 0.001) and HOMA-IR (r = −0.305, p < 0.05) but not with waist circumference (r = 0.079), body mass index (r = 0.028), total cholesterol (r = 0.061) or triglycerides (r = 0.009). Diabetics had higher HOMA-IR (p < 0.01) and lower osteocalcin levels (p < 0.01) than non-diabetics. Among diabetics, osteocalcin correlated with glucose only (r = −0.341, p = 0.015). In non-diabetics, osteocalcin correlated with HOMA-IR (r = −0.359, p = 0.023) via insulin (r = −0.402, p = 0.010). Patients with impaired fasting glucose levels (5.6–6.9 mmol/L) had the same HOMA-IR as diabetics (p = 0.076) but not low osteocalcin (p = 0.025). Conclusions In this cross-sectional study of subjects with metabolic syndrome and central obesity, low osteocalcin was associated with diabetes but not adiposity.",
keywords = "Adiposity, Central obesity, Diabetes, Metabolic syndrome, Osteocalcin",
author = "Mazlan, {Khalidah Adibah} and Wee, {Lim D.} and Halim, {Siti Aizon A.} and Fadi, {Mohd Faris M.} and Premalatha Santhiran and Rosli, {Nabila F.} and Norlaila Mustafa",
year = "2016",
doi = "10.1016/j.dsx.2015.09.009",
language = "English",
volume = "10",
pages = "S42--S45",
journal = "Diabetes and Metabolic Syndrome: Clinical Research and Reviews",
issn = "1871-4021",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Serum osteocalcin in subjects with metabolic syndrome and central obesity

AU - Mazlan, Khalidah Adibah

AU - Wee, Lim D.

AU - Halim, Siti Aizon A.

AU - Fadi, Mohd Faris M.

AU - Santhiran, Premalatha

AU - Rosli, Nabila F.

AU - Mustafa, Norlaila

PY - 2016

Y1 - 2016

N2 - Aims The aim of this study was to determine if osteocalcin is related to adiposity and hyperglycaemia in metabolic syndrome irrespective of the presence of diabetes mellitus. Materials and Methods This was a cross sectional study of 90 patients (59 men and 31 women) with metabolic syndrome as defined by the International Diabetes Federation criteria. Based on medical history 50 out of 90 patients had a diabetes. Anthropometric data were collected and blood taken for measurement of osteocalcin, fasting lipids, fasting glucose and insulin resistance (using homeostatic model assessment index, HOMA-IR). Results Osteocalcin correlated negatively with fasting glucose (r = −0.366, p < 0.001) and HOMA-IR (r = −0.305, p < 0.05) but not with waist circumference (r = 0.079), body mass index (r = 0.028), total cholesterol (r = 0.061) or triglycerides (r = 0.009). Diabetics had higher HOMA-IR (p < 0.01) and lower osteocalcin levels (p < 0.01) than non-diabetics. Among diabetics, osteocalcin correlated with glucose only (r = −0.341, p = 0.015). In non-diabetics, osteocalcin correlated with HOMA-IR (r = −0.359, p = 0.023) via insulin (r = −0.402, p = 0.010). Patients with impaired fasting glucose levels (5.6–6.9 mmol/L) had the same HOMA-IR as diabetics (p = 0.076) but not low osteocalcin (p = 0.025). Conclusions In this cross-sectional study of subjects with metabolic syndrome and central obesity, low osteocalcin was associated with diabetes but not adiposity.

AB - Aims The aim of this study was to determine if osteocalcin is related to adiposity and hyperglycaemia in metabolic syndrome irrespective of the presence of diabetes mellitus. Materials and Methods This was a cross sectional study of 90 patients (59 men and 31 women) with metabolic syndrome as defined by the International Diabetes Federation criteria. Based on medical history 50 out of 90 patients had a diabetes. Anthropometric data were collected and blood taken for measurement of osteocalcin, fasting lipids, fasting glucose and insulin resistance (using homeostatic model assessment index, HOMA-IR). Results Osteocalcin correlated negatively with fasting glucose (r = −0.366, p < 0.001) and HOMA-IR (r = −0.305, p < 0.05) but not with waist circumference (r = 0.079), body mass index (r = 0.028), total cholesterol (r = 0.061) or triglycerides (r = 0.009). Diabetics had higher HOMA-IR (p < 0.01) and lower osteocalcin levels (p < 0.01) than non-diabetics. Among diabetics, osteocalcin correlated with glucose only (r = −0.341, p = 0.015). In non-diabetics, osteocalcin correlated with HOMA-IR (r = −0.359, p = 0.023) via insulin (r = −0.402, p = 0.010). Patients with impaired fasting glucose levels (5.6–6.9 mmol/L) had the same HOMA-IR as diabetics (p = 0.076) but not low osteocalcin (p = 0.025). Conclusions In this cross-sectional study of subjects with metabolic syndrome and central obesity, low osteocalcin was associated with diabetes but not adiposity.

KW - Adiposity

KW - Central obesity

KW - Diabetes

KW - Metabolic syndrome

KW - Osteocalcin

UR - http://www.scopus.com/inward/record.url?scp=84996497090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84996497090&partnerID=8YFLogxK

U2 - 10.1016/j.dsx.2015.09.009

DO - 10.1016/j.dsx.2015.09.009

M3 - Article

VL - 10

SP - S42-S45

JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

SN - 1871-4021

IS - 1

ER -