Serum neutrophil gelatinase-associated lipocalin and cystatin C are early biomarkers of contrast-induced nephropathy after coronary angiography in patients with chronic kidney disease

Sabah Mohamed Alharazy, Norella Kong, Rashidi Saidin, Abdul Halim Abdul Gafor, Oteh Maskon, Marlyn Mohd, Syed Zulkifli Syed Zakaria

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23 Citations (Scopus)

Abstract

We had previously reported on serum neutrophil gelatinase-associated lipocalin (NGAL) as an earlier biomarker of contrast-induced nephropathy (CIN) than serum creatinine (SCr) in 100 patients with chronic kidney disease undergoing coronary angiography.1 We then compared serum NGAL to serum cystatin C (CysC) in the same group of patients. The SCr, estimated glomerular filtration rate, serum NGAL, and serum CysC were measured at baseline and various time points as appropriate postprocedure. The frequency of CIN was 11% (n = 11). Serum NGAL increased ≥25% from baseline at 24 hours in 7 patients with CIN (P =.04). Serum CysC increased ≥25% from baseline at 24 hours in 4 patients with CIN (P =.008). Changes in serum NGAL and serum CysC from baseline at 24 hours (â-μ values) could diagnose CIN 24 hours earlier than SCr with serum NGAL showing a superior performance.

Original languageEnglish
Pages (from-to)436-442
Number of pages7
JournalAngiology
Volume65
Issue number5
DOIs
Publication statusPublished - 2014

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Cystatin C
Coronary Angiography
Chronic Renal Insufficiency
Biomarkers
Serum
Creatinine
Lipocalin-2
Glomerular Filtration Rate

Keywords

  • chronic kidney disease
  • contrast-induced nephropathy
  • coronary angiography
  • cystatin C
  • neutrophil gelatinase-associated lipocalin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Serum neutrophil gelatinase-associated lipocalin and cystatin C are early biomarkers of contrast-induced nephropathy after coronary angiography in patients with chronic kidney disease",
abstract = "We had previously reported on serum neutrophil gelatinase-associated lipocalin (NGAL) as an earlier biomarker of contrast-induced nephropathy (CIN) than serum creatinine (SCr) in 100 patients with chronic kidney disease undergoing coronary angiography.1 We then compared serum NGAL to serum cystatin C (CysC) in the same group of patients. The SCr, estimated glomerular filtration rate, serum NGAL, and serum CysC were measured at baseline and various time points as appropriate postprocedure. The frequency of CIN was 11{\%} (n = 11). Serum NGAL increased ≥25{\%} from baseline at 24 hours in 7 patients with CIN (P =.04). Serum CysC increased ≥25{\%} from baseline at 24 hours in 4 patients with CIN (P =.008). Changes in serum NGAL and serum CysC from baseline at 24 hours ({\^a}-μ values) could diagnose CIN 24 hours earlier than SCr with serum NGAL showing a superior performance.",
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author = "Alharazy, {Sabah Mohamed} and Norella Kong and Rashidi Saidin and {Abdul Gafor}, {Abdul Halim} and Oteh Maskon and Marlyn Mohd and {Syed Zakaria}, {Syed Zulkifli}",
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T1 - Serum neutrophil gelatinase-associated lipocalin and cystatin C are early biomarkers of contrast-induced nephropathy after coronary angiography in patients with chronic kidney disease

AU - Alharazy, Sabah Mohamed

AU - Kong, Norella

AU - Saidin, Rashidi

AU - Abdul Gafor, Abdul Halim

AU - Maskon, Oteh

AU - Mohd, Marlyn

AU - Syed Zakaria, Syed Zulkifli

PY - 2014

Y1 - 2014

N2 - We had previously reported on serum neutrophil gelatinase-associated lipocalin (NGAL) as an earlier biomarker of contrast-induced nephropathy (CIN) than serum creatinine (SCr) in 100 patients with chronic kidney disease undergoing coronary angiography.1 We then compared serum NGAL to serum cystatin C (CysC) in the same group of patients. The SCr, estimated glomerular filtration rate, serum NGAL, and serum CysC were measured at baseline and various time points as appropriate postprocedure. The frequency of CIN was 11% (n = 11). Serum NGAL increased ≥25% from baseline at 24 hours in 7 patients with CIN (P =.04). Serum CysC increased ≥25% from baseline at 24 hours in 4 patients with CIN (P =.008). Changes in serum NGAL and serum CysC from baseline at 24 hours (â-μ values) could diagnose CIN 24 hours earlier than SCr with serum NGAL showing a superior performance.

AB - We had previously reported on serum neutrophil gelatinase-associated lipocalin (NGAL) as an earlier biomarker of contrast-induced nephropathy (CIN) than serum creatinine (SCr) in 100 patients with chronic kidney disease undergoing coronary angiography.1 We then compared serum NGAL to serum cystatin C (CysC) in the same group of patients. The SCr, estimated glomerular filtration rate, serum NGAL, and serum CysC were measured at baseline and various time points as appropriate postprocedure. The frequency of CIN was 11% (n = 11). Serum NGAL increased ≥25% from baseline at 24 hours in 7 patients with CIN (P =.04). Serum CysC increased ≥25% from baseline at 24 hours in 4 patients with CIN (P =.008). Changes in serum NGAL and serum CysC from baseline at 24 hours (â-μ values) could diagnose CIN 24 hours earlier than SCr with serum NGAL showing a superior performance.

KW - chronic kidney disease

KW - contrast-induced nephropathy

KW - coronary angiography

KW - cystatin C

KW - neutrophil gelatinase-associated lipocalin

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