Serum levels of squamous cell carcinoma antigen and CA 125 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix

M. L. Looi, M. D. Ahmad Zailani Hatta, M. A. Siti Aishah, M. H. Baizurah, W. N. Wan Zurinah, Yasmin Anum Mohd Yusof

Research output: Contribution to journalArticle

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Abstract

The aim of this study is to determine whether Squamous Cell Carcinoma Antigen (SCC-Ag) and (Cancer Antigen) CA 125 are helpful in determining the stage of cervical cancer. The Serum levels of (SCC-Ag) and CA 125 were determined by enzyme immunoassay in 26 patients with Squamous Cell Carcinoma (SCC) of the uterine cervix, 30 patients with Cervical Intraepithelial Neoplasia (CIN) and in 35 healthy women (normal control). The cut-off values for SCC-Ag and CA 125 were chosen at 1.80 υg L-1 and 35.0 U mL-1, respectively. Elevated SCC-Ag levels were found in 69% of patients with SCC with a specificity of 97%. Sensitivity and specificity of serum CA 125 were 23 and 97%, respectively. Statistical analysis showed that advanced SCC (FIGO stage III and IV) had significantly higher levels of serum SCC-Ag than CIN and normal control (p = 0.0001). However, increased levels of CA 125 were only found in SCC stage IV. There were no significant differences in serum SCC-Ag and CA 125 levels between CIN and normal control. Using chi-square test, we found a strong correlation (p = 0.0140) between the staging of SCC and the elevation of senim SCC-Ag but not for CA 125 (p = 0.5080). We concluded that SCC-Ag is a better tumor marker than CA 125 in detecting squamous cell carcinoma of the cervix and its level in serum correlated with staging of cervical SCC.

Original languageEnglish
Pages (from-to)212-218
Number of pages7
JournalInternational Journal of Cancer Research
Volume2
Issue number3
Publication statusPublished - 2006

Fingerprint

Cervical Intraepithelial Neoplasia
Cervix Uteri
Squamous Cell Carcinoma
Serum
CA-125 Antigen
squamous cell carcinoma-related antigen
Chi-Square Distribution
Tumor Biomarkers
Immunoenzyme Techniques
Uterine Cervical Neoplasms
Sensitivity and Specificity

Keywords

  • CA 125
  • Cervical cancer
  • Cervical Intraepithelial Neoplasia
  • SCC-Ag
  • Serum markers
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Looi, M. L., Ahmad Zailani Hatta, M. D., Siti Aishah, M. A., Baizurah, M. H., Wan Zurinah, W. N., & Mohd Yusof, Y. A. (2006). Serum levels of squamous cell carcinoma antigen and CA 125 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. International Journal of Cancer Research, 2(3), 212-218.

Serum levels of squamous cell carcinoma antigen and CA 125 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. / Looi, M. L.; Ahmad Zailani Hatta, M. D.; Siti Aishah, M. A.; Baizurah, M. H.; Wan Zurinah, W. N.; Mohd Yusof, Yasmin Anum.

In: International Journal of Cancer Research, Vol. 2, No. 3, 2006, p. 212-218.

Research output: Contribution to journalArticle

Looi, ML, Ahmad Zailani Hatta, MD, Siti Aishah, MA, Baizurah, MH, Wan Zurinah, WN & Mohd Yusof, YA 2006, 'Serum levels of squamous cell carcinoma antigen and CA 125 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix', International Journal of Cancer Research, vol. 2, no. 3, pp. 212-218.
Looi, M. L. ; Ahmad Zailani Hatta, M. D. ; Siti Aishah, M. A. ; Baizurah, M. H. ; Wan Zurinah, W. N. ; Mohd Yusof, Yasmin Anum. / Serum levels of squamous cell carcinoma antigen and CA 125 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. In: International Journal of Cancer Research. 2006 ; Vol. 2, No. 3. pp. 212-218.
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abstract = "The aim of this study is to determine whether Squamous Cell Carcinoma Antigen (SCC-Ag) and (Cancer Antigen) CA 125 are helpful in determining the stage of cervical cancer. The Serum levels of (SCC-Ag) and CA 125 were determined by enzyme immunoassay in 26 patients with Squamous Cell Carcinoma (SCC) of the uterine cervix, 30 patients with Cervical Intraepithelial Neoplasia (CIN) and in 35 healthy women (normal control). The cut-off values for SCC-Ag and CA 125 were chosen at 1.80 υg L-1 and 35.0 U mL-1, respectively. Elevated SCC-Ag levels were found in 69{\%} of patients with SCC with a specificity of 97{\%}. Sensitivity and specificity of serum CA 125 were 23 and 97{\%}, respectively. Statistical analysis showed that advanced SCC (FIGO stage III and IV) had significantly higher levels of serum SCC-Ag than CIN and normal control (p = 0.0001). However, increased levels of CA 125 were only found in SCC stage IV. There were no significant differences in serum SCC-Ag and CA 125 levels between CIN and normal control. Using chi-square test, we found a strong correlation (p = 0.0140) between the staging of SCC and the elevation of senim SCC-Ag but not for CA 125 (p = 0.5080). We concluded that SCC-Ag is a better tumor marker than CA 125 in detecting squamous cell carcinoma of the cervix and its level in serum correlated with staging of cervical SCC.",
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