Serum folate concentration, cognitive impairment, and DNA damage among elderly individuals in Malaysia

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The notion that dietary factors affect cognitive function and subsequently the risk of dementia has increased over the years from a global viewpoint. Because low folate intake has been described to impair cognitive function, we tested the hypothesis that low serum folate concentration is associated with cognitive impairment and an attenuated increase in DNA damage. We investigated the relationship between serum folate concentration, cognitive impairment, and DNA damage among elderly people attending health clinics in Klang Valley, an urban area in Malaysia. Two hundred thirty-two participants, composed of 115 men (49.6%) and 117 women (50.4%), were involved; none of the patients were diagnosed with neuropsychiatric problems, nor where they terminally ill. Sociodemography and health variables were assessed through face-to-face interview. Cognitive impairment review was conducted through an Elderly Cognitive Assessment Questionnaire. The estimation of dietary intake, serum folate concentration, and DNA damage was individually analyzed using validated Dietary History Questionnaires, immunoassay methods, and an Alkaline Comet Assay study (10 mL of peripheral venous blood), respectively. Results indicated that more men had cognitive impairment (33.0%) and DNA damage (27.0% for percentage DNA in tail, 22.6% tail moment) compared with women (25.6%, 15.4%, and 15.4%, respectively) (P < .05 for all parameters), recording an average folate deficiency value of 13.9% (0.2% higher than women). Multivariate binary logistic regression analysis outlined the association of cognitive impairment with older age (odds ratio [OR], 2.74; 95% confidence interval [CI], 1.35-5.57), smoking habits (OR, 5.12; 95% CI, 2.48-10.57), poor serum folate concentration (OR, 3.46; 95% CI, 1.26-9.52), and DNA damage (percentage DNA in tail) (OR, 13.70; 95% CI, 1.36-138.29). In conclusion, this study highlighted the important role of serum folate concentration for cognitive function and provided a concise picture regarding the elevated levels of oxidative DNA damage in peripheral lymphocytes.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalNutrition Research
Volume29
Issue number5
DOIs
Publication statusPublished - May 2009

Fingerprint

Malaysia
Folic Acid
DNA Damage
Serum
Odds Ratio
Confidence Intervals
Cognition
Terminally Ill
Comet Assay
DNA
Health
Cognitive Dysfunction
Immunoassay
Habits
Dementia
Logistic Models
Smoking
Regression Analysis
Lymphocytes
Interviews

Keywords

  • Cognitive impairment
  • DNA damage
  • Elderly people
  • Lymphocytes
  • Serum folate concentration

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Serum folate concentration, cognitive impairment, and DNA damage among elderly individuals in Malaysia. / Lee, Lai Kuan; Shahar, Suzana; Rajab, Nor Fadilah.

In: Nutrition Research, Vol. 29, No. 5, 05.2009, p. 327-334.

Research output: Contribution to journalArticle

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abstract = "The notion that dietary factors affect cognitive function and subsequently the risk of dementia has increased over the years from a global viewpoint. Because low folate intake has been described to impair cognitive function, we tested the hypothesis that low serum folate concentration is associated with cognitive impairment and an attenuated increase in DNA damage. We investigated the relationship between serum folate concentration, cognitive impairment, and DNA damage among elderly people attending health clinics in Klang Valley, an urban area in Malaysia. Two hundred thirty-two participants, composed of 115 men (49.6{\%}) and 117 women (50.4{\%}), were involved; none of the patients were diagnosed with neuropsychiatric problems, nor where they terminally ill. Sociodemography and health variables were assessed through face-to-face interview. Cognitive impairment review was conducted through an Elderly Cognitive Assessment Questionnaire. The estimation of dietary intake, serum folate concentration, and DNA damage was individually analyzed using validated Dietary History Questionnaires, immunoassay methods, and an Alkaline Comet Assay study (10 mL of peripheral venous blood), respectively. Results indicated that more men had cognitive impairment (33.0{\%}) and DNA damage (27.0{\%} for percentage DNA in tail, 22.6{\%} tail moment) compared with women (25.6{\%}, 15.4{\%}, and 15.4{\%}, respectively) (P < .05 for all parameters), recording an average folate deficiency value of 13.9{\%} (0.2{\%} higher than women). Multivariate binary logistic regression analysis outlined the association of cognitive impairment with older age (odds ratio [OR], 2.74; 95{\%} confidence interval [CI], 1.35-5.57), smoking habits (OR, 5.12; 95{\%} CI, 2.48-10.57), poor serum folate concentration (OR, 3.46; 95{\%} CI, 1.26-9.52), and DNA damage (percentage DNA in tail) (OR, 13.70; 95{\%} CI, 1.36-138.29). In conclusion, this study highlighted the important role of serum folate concentration for cognitive function and provided a concise picture regarding the elevated levels of oxidative DNA damage in peripheral lymphocytes.",
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