Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia

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Abstract

Objectives The risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous population might shed a new light in the disease mechanism. This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder. Methods This is a candidate gene association study of randomly selected forty five unrelated bipolar disorder probands and sixty six controls. Diagnosis was evaluated using the Mini International Neuropsychiatric Interview (M.I.N.I). The control group consisted of healthy volunteers without personal psychiatric history and family history of mood disorder. Patients' whole blood was collected for genotyping. Results This study revealed that the frequency of the short variant of 5-HTTLPR in healthy control group was highest in Indians (42.9%) followed by Malays (23.5%) and was absent in Chinese. The association between the homozygous ss genotype of the 5-HTTLPR polymorphism with bipolar disorder was not found in the pooled subjects (χ2 = 1.52, d.f. = 1, p = 0.218, OR = 4.67, 95% C.I. = 0.69-7.58) and after stratification into Malays (p = 0.315, OR = 2.03, 95% CI = 0.50-8.17), Indians (p = 0.310; OR = 0.44, 95% CI = 0.21-0.92) and Chinese. Conclusion The differences in the frequency of the short allele of 5-HTTLPR across the three main ethnic groups in Malaysia were noteworthy. The present study showed no significant association between the homozygous short variant of the 5-HTTLPR and bipolar disorder in the pooled subject and after stratification into the three main ethnic groups in Malaysia.

Original languageEnglish
JournalComprehensive Psychiatry
Volume55
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 2014

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Serotonin Plasma Membrane Transport Proteins
Malaysia
Bipolar Disorder
Ethnic Groups
Genes
Control Groups
Population Genetics
Genetic Association Studies
Mood Disorders
Gene Frequency
Psychiatry
Healthy Volunteers
Genotype
Interviews
Light
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

@article{f1fb07fe80914fbd865a82ad0c6e9399,
title = "Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia",
abstract = "Objectives The risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous population might shed a new light in the disease mechanism. This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder. Methods This is a candidate gene association study of randomly selected forty five unrelated bipolar disorder probands and sixty six controls. Diagnosis was evaluated using the Mini International Neuropsychiatric Interview (M.I.N.I). The control group consisted of healthy volunteers without personal psychiatric history and family history of mood disorder. Patients' whole blood was collected for genotyping. Results This study revealed that the frequency of the short variant of 5-HTTLPR in healthy control group was highest in Indians (42.9{\%}) followed by Malays (23.5{\%}) and was absent in Chinese. The association between the homozygous ss genotype of the 5-HTTLPR polymorphism with bipolar disorder was not found in the pooled subjects (χ2 = 1.52, d.f. = 1, p = 0.218, OR = 4.67, 95{\%} C.I. = 0.69-7.58) and after stratification into Malays (p = 0.315, OR = 2.03, 95{\%} CI = 0.50-8.17), Indians (p = 0.310; OR = 0.44, 95{\%} CI = 0.21-0.92) and Chinese. Conclusion The differences in the frequency of the short allele of 5-HTTLPR across the three main ethnic groups in Malaysia were noteworthy. The present study showed no significant association between the homozygous short variant of the 5-HTTLPR and bipolar disorder in the pooled subject and after stratification into the three main ethnic groups in Malaysia.",
author = "{Mohamed Saini}, Suriati and {Nik Jaafar}, {Nik Ruzyanei} and Hatta Sidi and Marhani Midin and {Mohd Radzi}, Azizah and {Abdul Rahman}, {Abdul Hamid}",
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language = "English",
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TY - JOUR

T1 - Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia

AU - Mohamed Saini, Suriati

AU - Nik Jaafar, Nik Ruzyanei

AU - Sidi, Hatta

AU - Midin, Marhani

AU - Mohd Radzi, Azizah

AU - Abdul Rahman, Abdul Hamid

PY - 2014/1

Y1 - 2014/1

N2 - Objectives The risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous population might shed a new light in the disease mechanism. This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder. Methods This is a candidate gene association study of randomly selected forty five unrelated bipolar disorder probands and sixty six controls. Diagnosis was evaluated using the Mini International Neuropsychiatric Interview (M.I.N.I). The control group consisted of healthy volunteers without personal psychiatric history and family history of mood disorder. Patients' whole blood was collected for genotyping. Results This study revealed that the frequency of the short variant of 5-HTTLPR in healthy control group was highest in Indians (42.9%) followed by Malays (23.5%) and was absent in Chinese. The association between the homozygous ss genotype of the 5-HTTLPR polymorphism with bipolar disorder was not found in the pooled subjects (χ2 = 1.52, d.f. = 1, p = 0.218, OR = 4.67, 95% C.I. = 0.69-7.58) and after stratification into Malays (p = 0.315, OR = 2.03, 95% CI = 0.50-8.17), Indians (p = 0.310; OR = 0.44, 95% CI = 0.21-0.92) and Chinese. Conclusion The differences in the frequency of the short allele of 5-HTTLPR across the three main ethnic groups in Malaysia were noteworthy. The present study showed no significant association between the homozygous short variant of the 5-HTTLPR and bipolar disorder in the pooled subject and after stratification into the three main ethnic groups in Malaysia.

AB - Objectives The risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous population might shed a new light in the disease mechanism. This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder. Methods This is a candidate gene association study of randomly selected forty five unrelated bipolar disorder probands and sixty six controls. Diagnosis was evaluated using the Mini International Neuropsychiatric Interview (M.I.N.I). The control group consisted of healthy volunteers without personal psychiatric history and family history of mood disorder. Patients' whole blood was collected for genotyping. Results This study revealed that the frequency of the short variant of 5-HTTLPR in healthy control group was highest in Indians (42.9%) followed by Malays (23.5%) and was absent in Chinese. The association between the homozygous ss genotype of the 5-HTTLPR polymorphism with bipolar disorder was not found in the pooled subjects (χ2 = 1.52, d.f. = 1, p = 0.218, OR = 4.67, 95% C.I. = 0.69-7.58) and after stratification into Malays (p = 0.315, OR = 2.03, 95% CI = 0.50-8.17), Indians (p = 0.310; OR = 0.44, 95% CI = 0.21-0.92) and Chinese. Conclusion The differences in the frequency of the short allele of 5-HTTLPR across the three main ethnic groups in Malaysia were noteworthy. The present study showed no significant association between the homozygous short variant of the 5-HTTLPR and bipolar disorder in the pooled subject and after stratification into the three main ethnic groups in Malaysia.

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DO - 10.1016/j.comppsych.2012.12.005

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JO - Comprehensive Psychiatry

JF - Comprehensive Psychiatry

SN - 0010-440X

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