Seroprevalence of anti-Toxoplasma gondii IgG antibody in patients with schizophrenia

Emelia Osman, R. N. Amal, Z. Z. Ruzanna, H. Shahida, Z. Azzubair, K. S. Tan, S. Noor Aadila, N. A M Siti, M. Y. Aisah

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Abstract

Schizophrenia is a pervasive neuropsychiatric disease of unknown cause. Previous studies have reported that toxoplasmosis may be a possible cause of schizophrenia. To ascertain possible relationship between Toxoplasma gondii and schizophrenia, a cross sectional study, employing an enzyme-linked immunosorbent assay (ELISA) was performed to study the seroprevalence of anti-T. gondii IgG antibody in schizophrenic patients. Furthermore, demographic data analysis from schizophrenic patients were analysed to associate toxoplasmosis with schizophrenia. A total of 288 serum samples from schizophrenic patients (n=144) and psychiatrically healthy volunteers (n=144) were recruited in this study. Interestingly, a significant result in the serointensity rate of anti-T. gondii IgG antibody (> 60IU/mL) in schizophrenic patients (61.1%) was demonstrated as compared to psychiatrically healthy volunteers (40.8%) (X 2= 4.236, p < 0.050). However, there was no significant difference between the seropositivity rate of anti-T. gondii IgG antibody between the two groups. Analysis from demographic data revealed that the seropositivity rate of anti-T. gondii IgG antibody in schizophrenic patients was significantly associated with age group of more than 40 years old (p=0.007) and between ethnic (p=0.046). Nevertheless, no significant association between seropositivity rate of anti-T. gondii IgG antibody with gender (p=0.897), duration of illness (p=0.344) and family history of schizophrenia (p=0.282) in these patients. Thus, this finding is essential as a preliminary data in Malaysia to establish the association between T. gondii and schizophrenia.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalTropical Biomedicine
Volume29
Issue number1
Publication statusPublished - Mar 2012

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Toxoplasma
Seroepidemiologic Studies
Schizophrenia
Immunoglobulin G
Antibodies
Toxoplasmosis
Healthy Volunteers
Demography
Malaysia
Age Groups
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Thomsen-Friedenreich antibodies
Serum

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Osman, E., Amal, R. N., Ruzanna, Z. Z., Shahida, H., Azzubair, Z., Tan, K. S., ... Aisah, M. Y. (2012). Seroprevalence of anti-Toxoplasma gondii IgG antibody in patients with schizophrenia. Tropical Biomedicine, 29(1), 151-159.

Seroprevalence of anti-Toxoplasma gondii IgG antibody in patients with schizophrenia. / Osman, Emelia; Amal, R. N.; Ruzanna, Z. Z.; Shahida, H.; Azzubair, Z.; Tan, K. S.; Noor Aadila, S.; Siti, N. A M; Aisah, M. Y.

In: Tropical Biomedicine, Vol. 29, No. 1, 03.2012, p. 151-159.

Research output: Contribution to journalArticle

Osman, E, Amal, RN, Ruzanna, ZZ, Shahida, H, Azzubair, Z, Tan, KS, Noor Aadila, S, Siti, NAM & Aisah, MY 2012, 'Seroprevalence of anti-Toxoplasma gondii IgG antibody in patients with schizophrenia', Tropical Biomedicine, vol. 29, no. 1, pp. 151-159.
Osman E, Amal RN, Ruzanna ZZ, Shahida H, Azzubair Z, Tan KS et al. Seroprevalence of anti-Toxoplasma gondii IgG antibody in patients with schizophrenia. Tropical Biomedicine. 2012 Mar;29(1):151-159.
Osman, Emelia ; Amal, R. N. ; Ruzanna, Z. Z. ; Shahida, H. ; Azzubair, Z. ; Tan, K. S. ; Noor Aadila, S. ; Siti, N. A M ; Aisah, M. Y. / Seroprevalence of anti-Toxoplasma gondii IgG antibody in patients with schizophrenia. In: Tropical Biomedicine. 2012 ; Vol. 29, No. 1. pp. 151-159.
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