Seropositivity and serointensity of Toxoplasma gondii antibodies and DNA among patients with schizophrenia

Ainsah Omar, Osman Che Bakar, Nor Fatini Adam, Hakim Osman, Arina Osman, Ahmad Hatim Suleiman, Mohd Rizal Abdul Manaf, Mohd Ikhsan Selamat

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this cross sectional case control study was to examine the serofrequency and serointensity of Toxoplasma gondii (Tg) IgG, IgM, and DNA among patients with schizophrenia. A total of 101 patients with schizophrenia and 55 healthy controls from Sungai Buloh Hospital, Selangor, Malaysia and University Malaya Medical Center (UMMC) were included in this study. The diagnosis of schizophrenia was made based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). The presence of Tg infection was examined using both indirect (ELISA) and direct (quantitative real-time PCR) detection methods by measuring Tg IgG and IgM and DNA, respectively. The serofrequency of Tg IgG antibodies (51.5%, 52/101) and DNA (32.67%, 33/101) among patients with schizophrenia was significantly higher than IgG (18.2%, 10/55) and DNA (3.64%, 2/55) of the controls (IgG, P=0.000, OD=4.8, CI=2.2-10.5; DNA, P=0.000, OD=12.9, CI=2.17-10.51). However, the Tg IgM antibody between patients with schizophrenia and controls was not significant (P>0.005). There was no significant difference (P>0.005) in both serointensity of Tg IgG and DNA be­tween patients with schizophrenia and controls. These findings have further demonstrated the strong association between the active Tg infection and schizophrenia.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalKorean Journal of Parasitology
Volume53
Issue number1
DOIs
Publication statusPublished - 1 Feb 2015

Fingerprint

Toxoplasma
Schizophrenia
Immunoglobulin G
Antibodies
DNA
Immunoglobulin M
Malaysia
Toxoplasmosis
Diagnostic and Statistical Manual of Mental Disorders
Case-Control Studies
Real-Time Polymerase Chain Reaction
Enzyme-Linked Immunosorbent Assay

Keywords

  • Schizophrenia
  • Serofrequency
  • Serointensity
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Omar, A., Bakar, O. C., Adam, N. F., Osman, H., Osman, A., Suleiman, A. H., ... Selamat, M. I. (2015). Seropositivity and serointensity of Toxoplasma gondii antibodies and DNA among patients with schizophrenia. Korean Journal of Parasitology, 53(1), 29-34. https://doi.org/10.3347/kjp.2015.53.1.29

Seropositivity and serointensity of Toxoplasma gondii antibodies and DNA among patients with schizophrenia. / Omar, Ainsah; Bakar, Osman Che; Adam, Nor Fatini; Osman, Hakim; Osman, Arina; Suleiman, Ahmad Hatim; Abdul Manaf, Mohd Rizal; Selamat, Mohd Ikhsan.

In: Korean Journal of Parasitology, Vol. 53, No. 1, 01.02.2015, p. 29-34.

Research output: Contribution to journalArticle

Omar, Ainsah ; Bakar, Osman Che ; Adam, Nor Fatini ; Osman, Hakim ; Osman, Arina ; Suleiman, Ahmad Hatim ; Abdul Manaf, Mohd Rizal ; Selamat, Mohd Ikhsan. / Seropositivity and serointensity of Toxoplasma gondii antibodies and DNA among patients with schizophrenia. In: Korean Journal of Parasitology. 2015 ; Vol. 53, No. 1. pp. 29-34.
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