Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization

King Hwa Ling, Marie Adele Rajandream, Pierre Rivailler, Alasdair Ivens, Soon Joo Yap, Alda M B N Madeira, Karen Mungall, Karen Billington, Wai Yan Yee, Alan T. Bankier, Fionnadh Carroll, Alan M. Durham, Nicholas Peters, Shu San Loo, Mohd Noor Mat Isa, Jeniffer Novaes, Michael Quail, Rozita Rosli, Mariana Nor Shamsudin, Tiago J P SobreiraAdrian R. Tivey, Siew Fun Wai, Sarah White, Xikun Wu, Arnaud Kerhornou, Damer Blake, Rahmah Mohamed, Martin Shirley, Arthur Gruber, Matthew Berriman, Fiona Tomley, Paul H. Dear, Kiew Lian Wan

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Eimeria tenella is an intracellular protozoan parasite that infects the intestinal tracts of domestic fowl and causes coccidiosis, a serious and sometimes lethal enteritis. Eimeria falls in the same phylum (Apicomplexa) as several human and animal parasites such as Cryptosporidium, Toxoplasma, and the malaria parasite, Plasmodium. Here we report the sequencing and analysis of the first chromosome of E. tenella, a chromosome believed to carry loci associated with drug resistance and known to differ between virulent and attenuated strains of the parasite. The chromosome - which appears to be representative of the genome - is gene-dense and rich in simple-sequence repeats, many of which appear to give rise to repetitive amino acid tracts in the predicted proteins. Most striking is the segmentation of the chromosome into repeat-rich regions peppered with transposon-like elements and telomere-like repeats, alternating with repeat-free regions. Predicted genes differ in character between the two types of segment, and the repeat-rich regions appear to be associated with strain-to-strain variation.

Original languageEnglish
Pages (from-to)311-319
Number of pages9
JournalGenome Research
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 2007

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Eimeria tenella
Chromosomes, Human, Pair 1
Parasites
Chromosomes
Chromosomes, Human, 16-18
Plasmodium malariae
Apicomplexa
Coccidiosis
Eimeria
Cryptosporidium
Enteritis
Telomere
Toxoplasma
Poultry
Drug Resistance
Microsatellite Repeats
Genes
Genome
Amino Acids
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Ling, K. H., Rajandream, M. A., Rivailler, P., Ivens, A., Yap, S. J., Madeira, A. M. B. N., ... Wan, K. L. (2007). Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization. Genome Research, 17(3), 311-319. https://doi.org/10.1101/gr.5823007

Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization. / Ling, King Hwa; Rajandream, Marie Adele; Rivailler, Pierre; Ivens, Alasdair; Yap, Soon Joo; Madeira, Alda M B N; Mungall, Karen; Billington, Karen; Yee, Wai Yan; Bankier, Alan T.; Carroll, Fionnadh; Durham, Alan M.; Peters, Nicholas; Loo, Shu San; Isa, Mohd Noor Mat; Novaes, Jeniffer; Quail, Michael; Rosli, Rozita; Nor Shamsudin, Mariana; Sobreira, Tiago J P; Tivey, Adrian R.; Wai, Siew Fun; White, Sarah; Wu, Xikun; Kerhornou, Arnaud; Blake, Damer; Mohamed, Rahmah; Shirley, Martin; Gruber, Arthur; Berriman, Matthew; Tomley, Fiona; Dear, Paul H.; Wan, Kiew Lian.

In: Genome Research, Vol. 17, No. 3, 03.2007, p. 311-319.

Research output: Contribution to journalArticle

Ling, KH, Rajandream, MA, Rivailler, P, Ivens, A, Yap, SJ, Madeira, AMBN, Mungall, K, Billington, K, Yee, WY, Bankier, AT, Carroll, F, Durham, AM, Peters, N, Loo, SS, Isa, MNM, Novaes, J, Quail, M, Rosli, R, Nor Shamsudin, M, Sobreira, TJP, Tivey, AR, Wai, SF, White, S, Wu, X, Kerhornou, A, Blake, D, Mohamed, R, Shirley, M, Gruber, A, Berriman, M, Tomley, F, Dear, PH & Wan, KL 2007, 'Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization', Genome Research, vol. 17, no. 3, pp. 311-319. https://doi.org/10.1101/gr.5823007
Ling KH, Rajandream MA, Rivailler P, Ivens A, Yap SJ, Madeira AMBN et al. Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization. Genome Research. 2007 Mar;17(3):311-319. https://doi.org/10.1101/gr.5823007
Ling, King Hwa ; Rajandream, Marie Adele ; Rivailler, Pierre ; Ivens, Alasdair ; Yap, Soon Joo ; Madeira, Alda M B N ; Mungall, Karen ; Billington, Karen ; Yee, Wai Yan ; Bankier, Alan T. ; Carroll, Fionnadh ; Durham, Alan M. ; Peters, Nicholas ; Loo, Shu San ; Isa, Mohd Noor Mat ; Novaes, Jeniffer ; Quail, Michael ; Rosli, Rozita ; Nor Shamsudin, Mariana ; Sobreira, Tiago J P ; Tivey, Adrian R. ; Wai, Siew Fun ; White, Sarah ; Wu, Xikun ; Kerhornou, Arnaud ; Blake, Damer ; Mohamed, Rahmah ; Shirley, Martin ; Gruber, Arthur ; Berriman, Matthew ; Tomley, Fiona ; Dear, Paul H. ; Wan, Kiew Lian. / Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization. In: Genome Research. 2007 ; Vol. 17, No. 3. pp. 311-319.
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