Semi-Quantitative and Qualitative Assessment of Breast Ultrasound Elastography in Differentiating Between Malignant and Benign Lesions

Sharifah Majedah Idrus Alhabshi, Kartini Rahmat, Nurazidawati Abdul Halim, Suraya Aziz, Radhika Sridharan, Gek Choo Gan, Anushya Vijayananthan, Caroline Judy Westerhout, Mohammad Nazri Mohd-Shah, Saladina Jaszle Jasmin, Nani Harlina Mohd Latar, Rohaizak Muhammad

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the diagnostic value of qualitative and semi-quantitative assessment of ultrasound elastography in differentiating between benign and malignant breast lesions. This prospective study was conducted in two tertiary medical centers. Consecutive B-mode ultrasound and real-time elastographic images were obtained for 67 malignant and 101 benign breast lesions in 168 women. Four experienced radiologists analyzed B-mode ultrasound alone and B-mode ultrasound combined with elastography independently. Conventional ultrasound findings were classified according to the American College of Radiology Breast Imaging Reporting and Data System classification. The elastographic assessment was based on qualitative and semi-quantitative parameters (. i.e., strain pattern, width ratio, strain ratio). The sensitivity and specificity of combined elastography and conventional ultrasound were significantly higher than that of conventional ultrasound alone. The sensitivity, specificity, positive predictive value and negative predictive value was 97%, 61.4%, 62.5% and 96.8%, respectively, for conventional ultrasound and 100%, 93%, 99% and 90%, respectively, for combined technique. The semi-quantitative assessment with strain ratio and width ratio in elastography were the most useful parameters in differentiating between benign and malignant breast lesions. Cut-off point values for width ratio of more than 1.1 and strain ratio of more than 5.6 showed a high predictive value of malignancy with specificities of 84% and 76%, respectively (. p < 0.001). This combined technique also had the best results in detecting carcinoma and could reduce the need of unnecessary biopsy for benign lesions with indeterminate or equivocal features.

Original languageEnglish
Pages (from-to)568-578
Number of pages11
JournalUltrasound in Medicine and Biology
Volume39
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Elasticity Imaging Techniques
breast
lesions
Breast
Sensitivity and Specificity
data systems
radiology
sensitivity
Radiology
Information Systems
cut-off
cancer
Prospective Studies
Carcinoma
Biopsy
Neoplasms

Keywords

  • Breast
  • Carcinoma
  • Elastography
  • Imaging
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Semi-Quantitative and Qualitative Assessment of Breast Ultrasound Elastography in Differentiating Between Malignant and Benign Lesions. / Idrus Alhabshi, Sharifah Majedah; Rahmat, Kartini; Abdul Halim, Nurazidawati; Aziz, Suraya; Sridharan, Radhika; Gan, Gek Choo; Vijayananthan, Anushya; Westerhout, Caroline Judy; Mohd-Shah, Mohammad Nazri; Jasmin, Saladina Jaszle; Harlina Mohd Latar, Nani; Muhammad, Rohaizak.

In: Ultrasound in Medicine and Biology, Vol. 39, No. 4, 04.2013, p. 568-578.

Research output: Contribution to journalArticle

Idrus Alhabshi, Sharifah Majedah ; Rahmat, Kartini ; Abdul Halim, Nurazidawati ; Aziz, Suraya ; Sridharan, Radhika ; Gan, Gek Choo ; Vijayananthan, Anushya ; Westerhout, Caroline Judy ; Mohd-Shah, Mohammad Nazri ; Jasmin, Saladina Jaszle ; Harlina Mohd Latar, Nani ; Muhammad, Rohaizak. / Semi-Quantitative and Qualitative Assessment of Breast Ultrasound Elastography in Differentiating Between Malignant and Benign Lesions. In: Ultrasound in Medicine and Biology. 2013 ; Vol. 39, No. 4. pp. 568-578.
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