Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains

Fazren Azmi, Alysha G. Elliott, Zeinab G. Khalil, Waleed M. Hussein, Angela Kavanagh, Johnny X. Huang, Michelle Quezada, Mark A T Blaskovich, Robert J. Capon, Matthew A. Cooper, Mariusz Skwarczynski, Istvan Toth

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: To explore the potential of de novo designed cyclic lipopeptides and its linear counterparts as antibacterial agents. Materials & methods: The lipopeptides were synthesized via solid-phase peptide synthesis and the cyclization was achieved by using succinic acid linker. The antimicrobial activities of the lipopeptides were evaluated in vitro against a variety selection of Gram-negative and Gram-positive bacteria including clinical isolates of multidrug-resistant strains. Results: The synthesized lipopeptides were able to self-assemble into nanoparticles in an aqueous environment, with three exhibiting potent antibacterial activity against Gram-positive bacteria, including clinically relevant multidrug-resistant bacteria. Conclusion: The lead compounds have the potential to be developed as new antibacterials that are effective against Gram-positive bacteria, including multidrug-resistant isolates.

Original languageEnglish
Pages (from-to)3359-3371
Number of pages13
JournalNanomedicine
Volume10
Issue number22
DOIs
Publication statusPublished - 1 Nov 2015

Fingerprint

Lipopeptides
Gram-Positive Bacteria
Bacteria
bacterium
Lead compounds
Bactericides
Solid-Phase Synthesis Techniques
antimicrobial activity
Cyclization
Succinic Acid
peptide
Nanoparticles
Peptides
Anti-Bacterial Agents
Acids
acid

Keywords

  • antibacterial activity
  • Gram-positive bacteria
  • lipopeptides
  • multidrug resistant
  • nanoparticles
  • self-assembly

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

Cite this

Azmi, F., Elliott, A. G., Khalil, Z. G., Hussein, W. M., Kavanagh, A., Huang, J. X., ... Toth, I. (2015). Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10(22), 3359-3371. https://doi.org/10.2217/nnm.15.137

Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. / Azmi, Fazren; Elliott, Alysha G.; Khalil, Zeinab G.; Hussein, Waleed M.; Kavanagh, Angela; Huang, Johnny X.; Quezada, Michelle; Blaskovich, Mark A T; Capon, Robert J.; Cooper, Matthew A.; Skwarczynski, Mariusz; Toth, Istvan.

In: Nanomedicine, Vol. 10, No. 22, 01.11.2015, p. 3359-3371.

Research output: Contribution to journalArticle

Azmi, F, Elliott, AG, Khalil, ZG, Hussein, WM, Kavanagh, A, Huang, JX, Quezada, M, Blaskovich, MAT, Capon, RJ, Cooper, MA, Skwarczynski, M & Toth, I 2015, 'Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains', Nanomedicine, vol. 10, no. 22, pp. 3359-3371. https://doi.org/10.2217/nnm.15.137
Azmi, Fazren ; Elliott, Alysha G. ; Khalil, Zeinab G. ; Hussein, Waleed M. ; Kavanagh, Angela ; Huang, Johnny X. ; Quezada, Michelle ; Blaskovich, Mark A T ; Capon, Robert J. ; Cooper, Matthew A. ; Skwarczynski, Mariusz ; Toth, Istvan. / Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. In: Nanomedicine. 2015 ; Vol. 10, No. 22. pp. 3359-3371.
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