Self-assembled potential bio nanocarriers for drug delivery

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Self-assembled nanocarriers attract increasing attention due to their wide application in various practical fields; among them, one of the most focused fields is drug delivery. Appropriate selection of surfactant is the basis for preparing a successful nanocarrier. Until now, from phospholipid to synthetic surfactants, many surfactants have been used to explore a suitable drug delivery vehicle for the complex in-vivo environment. Among all, bio surfactants are found to be more suitable due to their bio-origin, less-toxicity, biodegradability, cheaper rate and above all, their versatile molecular structures. This molecular property enables them to self assemble into fascinating structures. Moreover, binding DNA, enhancing pH sensitivity and stability allows novelty over their synthetic counterparts and phospholipid. This review paper focuses on the properties and applications of bio-nano-carriers for drug delivery. Micelle, microemulsion, and vesicle are the three nanocarriers which are discussed herein.

Original languageEnglish
Pages (from-to)1327-1339
Number of pages13
JournalMini-Reviews in Medicinal Chemistry
Volume13
Issue number9
DOIs
Publication statusPublished - 2013

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Surface-Active Agents
Pharmaceutical Preparations
Phospholipids
Drug Carriers
Micelles
Molecular Structure
DNA

Keywords

  • Biocompatible nanocarriers
  • Biosurfactants
  • Micelle
  • Microemulsion
  • Vesicle

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

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abstract = "Self-assembled nanocarriers attract increasing attention due to their wide application in various practical fields; among them, one of the most focused fields is drug delivery. Appropriate selection of surfactant is the basis for preparing a successful nanocarrier. Until now, from phospholipid to synthetic surfactants, many surfactants have been used to explore a suitable drug delivery vehicle for the complex in-vivo environment. Among all, bio surfactants are found to be more suitable due to their bio-origin, less-toxicity, biodegradability, cheaper rate and above all, their versatile molecular structures. This molecular property enables them to self assemble into fascinating structures. Moreover, binding DNA, enhancing pH sensitivity and stability allows novelty over their synthetic counterparts and phospholipid. This review paper focuses on the properties and applications of bio-nano-carriers for drug delivery. Micelle, microemulsion, and vesicle are the three nanocarriers which are discussed herein.",
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AU - Radiman, Shahidan

AU - K.P. Kunchi Mohamed, Faizal

AU - Reza, Mohammad Imam Hasan

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