Secondary metabolites of Sophora mollis subsp. griffithii (Stocks) Ali

Atta-Ur-Rahman, M. Sohail Haroone, Rasool Baksh Tareen, Osman Mesaik Mohammed Ahmed Hassan, Saleem Jan, Ahmed Abbaskhan, Muhammad Asif, Tahsin Gulzar, Abdullah M. Al-Majid, Sammer Yousuf, M. Iqbal Choudhary

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two new compounds, (+)-3,5,7-trihydroxy-3-[3′-hydroxy-2′, 4′-dimethoxy-5-(3-methyl-2-butenyl)]-phenyl-(3R)-4H-1-benzopyran-4-one (1) and (-)-3-hydroxy-8,9-methylenedioxy-(6aR,11aS)-pterocarpan (2), were isolated from the methanolic extract of Sophora mollis subsp. griffithii. Two known compounds, β-sitosterol (3) and 19βH-lupeol-methyl-ether (4), were also obtained for the first time from this plant. The structures of 1-4 were identified through their spectroscopic data. CD Spectroscopy was also utilized for the structure elucidation of compounds 1 and 2. Compounds 1, 3 and 4 were studied for their effects on immune cells and only 1 was found to be substantially active.

Original languageEnglish
Pages (from-to)613-616
Number of pages4
JournalPhytochemistry Letters
Volume5
Issue number3
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

Fingerprint

Pterocarpans
Sophora
benzopyrans
circular dichroism spectroscopy
lupeol
Methyl Ethers
sitosterols
Metabolites
secondary metabolites
ethers
Spectrum Analysis
Spectroscopy
extracts
cells
benzopyran-4-one
gamma-sitosterol

Keywords

  • CD Spectrum
  • Immunomodulatory activity
  • Leguminoseae
  • Sophora mollis
  • Sophoranone

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Biochemistry
  • Biotechnology

Cite this

Atta-Ur-Rahman, Haroone, M. S., Tareen, R. B., Mohammed Ahmed Hassan, O. M., Jan, S., Abbaskhan, A., ... Choudhary, M. I. (2012). Secondary metabolites of Sophora mollis subsp. griffithii (Stocks) Ali. Phytochemistry Letters, 5(3), 613-616. https://doi.org/10.1016/j.phytol.2012.06.006

Secondary metabolites of Sophora mollis subsp. griffithii (Stocks) Ali. / Atta-Ur-Rahman; Haroone, M. Sohail; Tareen, Rasool Baksh; Mohammed Ahmed Hassan, Osman Mesaik; Jan, Saleem; Abbaskhan, Ahmed; Asif, Muhammad; Gulzar, Tahsin; Al-Majid, Abdullah M.; Yousuf, Sammer; Choudhary, M. Iqbal.

In: Phytochemistry Letters, Vol. 5, No. 3, 09.2012, p. 613-616.

Research output: Contribution to journalArticle

Atta-Ur-Rahman, Haroone, MS, Tareen, RB, Mohammed Ahmed Hassan, OM, Jan, S, Abbaskhan, A, Asif, M, Gulzar, T, Al-Majid, AM, Yousuf, S & Choudhary, MI 2012, 'Secondary metabolites of Sophora mollis subsp. griffithii (Stocks) Ali', Phytochemistry Letters, vol. 5, no. 3, pp. 613-616. https://doi.org/10.1016/j.phytol.2012.06.006
Atta-Ur-Rahman, Haroone MS, Tareen RB, Mohammed Ahmed Hassan OM, Jan S, Abbaskhan A et al. Secondary metabolites of Sophora mollis subsp. griffithii (Stocks) Ali. Phytochemistry Letters. 2012 Sep;5(3):613-616. https://doi.org/10.1016/j.phytol.2012.06.006
Atta-Ur-Rahman ; Haroone, M. Sohail ; Tareen, Rasool Baksh ; Mohammed Ahmed Hassan, Osman Mesaik ; Jan, Saleem ; Abbaskhan, Ahmed ; Asif, Muhammad ; Gulzar, Tahsin ; Al-Majid, Abdullah M. ; Yousuf, Sammer ; Choudhary, M. Iqbal. / Secondary metabolites of Sophora mollis subsp. griffithii (Stocks) Ali. In: Phytochemistry Letters. 2012 ; Vol. 5, No. 3. pp. 613-616.
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