Screening for gestational diabetes in low-risk women: Effect of maternal age

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Abstract

Gestational diabetes mellitus (GDM) is on the rise globally and there are various screening guidelines with regard to patients' criteria. We conducted a prospective cross-sectional study to determine the prevalence of GDM amongst low-risk pregnant women above the age of 25 years. A modified glucose tolerance test (MGTT) was performed between 24 and 36 weeks of gestation. Women with GDM were divided into two groups for analysis: age between 25 and 34 years (group A) and above 35 years (group B). They were managed as per hospital protocol and followed-up until delivery. The women's demographic data, treatment and subsequent pregnancy outcomes were analysed. The overall prevalence of GDM in our low-risk women was 14%. GDM was less common in the younger age group (25-34 years) in comparison to those aged above 35 years (9.7% vs. 26.3%, p = 0.001). There was a non-significant increase in the induction of labour (IOL) rate amongst those aged below 35 years compared to the older group (46.7 % vs. 38.5%). The insulin requirement in the age group 25-34 years and above 35 years, were 6.7% and 23.1%, respectively. There was no significant difference between both age groups with regard to caesarean delivery, birth weight above the 95th centile and neonatal hypoglycaemia. In low-risk women, the prevalence of GDM is significantly lower in those aged less than 35 years. Diagnosing GDM had resulted in the increment of IOL in this group, although with no significant increase in maternal and neonatal morbidity.

Original languageEnglish
Article number20170071
JournalUnknown Journal
DOIs
Publication statusAccepted/In press - 9 Feb 2018

Fingerprint

Gestational Diabetes
diabetes
Maternal Age
Medical problems
Screening
Age Groups
Induced Labor
pregnancy
labor
Personnel
Insulin
morbidity
Pregnancy Outcome
Glucose Tolerance Test
woman
screening
effect
Hypoglycemia
Birth Weight
Glucose

Keywords

  • age
  • diabetes in pregnancy
  • gestational diabetes
  • screening

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Endocrinology

Cite this

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title = "Screening for gestational diabetes in low-risk women: Effect of maternal age",
abstract = "Gestational diabetes mellitus (GDM) is on the rise globally and there are various screening guidelines with regard to patients' criteria. We conducted a prospective cross-sectional study to determine the prevalence of GDM amongst low-risk pregnant women above the age of 25 years. A modified glucose tolerance test (MGTT) was performed between 24 and 36 weeks of gestation. Women with GDM were divided into two groups for analysis: age between 25 and 34 years (group A) and above 35 years (group B). They were managed as per hospital protocol and followed-up until delivery. The women's demographic data, treatment and subsequent pregnancy outcomes were analysed. The overall prevalence of GDM in our low-risk women was 14{\%}. GDM was less common in the younger age group (25-34 years) in comparison to those aged above 35 years (9.7{\%} vs. 26.3{\%}, p = 0.001). There was a non-significant increase in the induction of labour (IOL) rate amongst those aged below 35 years compared to the older group (46.7 {\%} vs. 38.5{\%}). The insulin requirement in the age group 25-34 years and above 35 years, were 6.7{\%} and 23.1{\%}, respectively. There was no significant difference between both age groups with regard to caesarean delivery, birth weight above the 95th centile and neonatal hypoglycaemia. In low-risk women, the prevalence of GDM is significantly lower in those aged less than 35 years. Diagnosing GDM had resulted in the increment of IOL in this group, although with no significant increase in maternal and neonatal morbidity.",
keywords = "age, diabetes in pregnancy, gestational diabetes, screening",
author = "{Aida Hani}, {Mohd Kalok} and Pravin Peraba and Shah, {Shamsul Azhar} and {Abdullah Mahdy}, Zaleha and Jamil, {Mohamad Abdul} and Kampan, {Nirmala @ Chandralega} and Suraya Sulaiman and {Mohamed Ismail}, {Nor Azlin}",
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T1 - Screening for gestational diabetes in low-risk women

T2 - Effect of maternal age

AU - Aida Hani, Mohd Kalok

AU - Peraba, Pravin

AU - Shah, Shamsul Azhar

AU - Abdullah Mahdy, Zaleha

AU - Jamil, Mohamad Abdul

AU - Kampan, Nirmala @ Chandralega

AU - Sulaiman, Suraya

AU - Mohamed Ismail, Nor Azlin

PY - 2018/2/9

Y1 - 2018/2/9

N2 - Gestational diabetes mellitus (GDM) is on the rise globally and there are various screening guidelines with regard to patients' criteria. We conducted a prospective cross-sectional study to determine the prevalence of GDM amongst low-risk pregnant women above the age of 25 years. A modified glucose tolerance test (MGTT) was performed between 24 and 36 weeks of gestation. Women with GDM were divided into two groups for analysis: age between 25 and 34 years (group A) and above 35 years (group B). They were managed as per hospital protocol and followed-up until delivery. The women's demographic data, treatment and subsequent pregnancy outcomes were analysed. The overall prevalence of GDM in our low-risk women was 14%. GDM was less common in the younger age group (25-34 years) in comparison to those aged above 35 years (9.7% vs. 26.3%, p = 0.001). There was a non-significant increase in the induction of labour (IOL) rate amongst those aged below 35 years compared to the older group (46.7 % vs. 38.5%). The insulin requirement in the age group 25-34 years and above 35 years, were 6.7% and 23.1%, respectively. There was no significant difference between both age groups with regard to caesarean delivery, birth weight above the 95th centile and neonatal hypoglycaemia. In low-risk women, the prevalence of GDM is significantly lower in those aged less than 35 years. Diagnosing GDM had resulted in the increment of IOL in this group, although with no significant increase in maternal and neonatal morbidity.

AB - Gestational diabetes mellitus (GDM) is on the rise globally and there are various screening guidelines with regard to patients' criteria. We conducted a prospective cross-sectional study to determine the prevalence of GDM amongst low-risk pregnant women above the age of 25 years. A modified glucose tolerance test (MGTT) was performed between 24 and 36 weeks of gestation. Women with GDM were divided into two groups for analysis: age between 25 and 34 years (group A) and above 35 years (group B). They were managed as per hospital protocol and followed-up until delivery. The women's demographic data, treatment and subsequent pregnancy outcomes were analysed. The overall prevalence of GDM in our low-risk women was 14%. GDM was less common in the younger age group (25-34 years) in comparison to those aged above 35 years (9.7% vs. 26.3%, p = 0.001). There was a non-significant increase in the induction of labour (IOL) rate amongst those aged below 35 years compared to the older group (46.7 % vs. 38.5%). The insulin requirement in the age group 25-34 years and above 35 years, were 6.7% and 23.1%, respectively. There was no significant difference between both age groups with regard to caesarean delivery, birth weight above the 95th centile and neonatal hypoglycaemia. In low-risk women, the prevalence of GDM is significantly lower in those aged less than 35 years. Diagnosing GDM had resulted in the increment of IOL in this group, although with no significant increase in maternal and neonatal morbidity.

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