SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: A multicenter cohort study and meta-analysis

Batoul Sadat Haerian, Larry Baum, Patrick Kwan, Hui Jan Tan, Raymond Azman Ali, Zahurin Mohamed

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Aim: Approximately a third of newly diagnosed epilepsy patients do not respond to antiepileptic drugs (AEDs). Evidence suggests that low penetrance variants in the genes of drug targets such as voltage-gated sodium channels may be involved in drug responsiveness. To examine this hypothesis, we compared data from two epilepsy cohorts from Malaysia and Hong Kong, as well as a meta-analysis from published data. Materials & methods: Genotype analysis of 39 polymorphisms located in the SCN1A, SCN2A and SCN3A genes was performed on 1504 epilepsy patients from Malaysia and Hong Kong who were receiving AEDs. Meta-analysis was performed for pooled data of SCN1A rs3812718 and rs2298771, and SCN2A rs17183814 polymorphisms. Results: Our data from the Hong Kong and Malaysia cohorts showed no significant allele, genotype and haplotype association of polymorphisms in the SCN1A, SCN2A, and SCN3A genes with drug responsiveness in epilepsy. This finding was supported by a meta-analysis for SCN1A rs3812718 and rs2298771, and for SCN2A rs17183814 polymorphisms. Conclusion: Our comprehensive study suggests that common polymorphisms in SCN1A, SCN2A and SCN3A do not play major roles in influencing response to AEDs.

Original languageEnglish
Pages (from-to)1153-1166
Number of pages14
JournalPharmacogenomics
Volume14
Issue number10
DOIs
Publication statusPublished - 2013

Fingerprint

Anticonvulsants
Multicenter Studies
Meta-Analysis
Epilepsy
Malaysia
Hong Kong
Cohort Studies
Genes
Genotype
Pharmaceutical Preparations
Voltage-Gated Sodium Channels
Penetrance
Haplotypes
Alleles

Keywords

  • drug responsiveness
  • epilepsy
  • polymorphism
  • SCN1A
  • SCN2A
  • SCN3A

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine
  • Medicine(all)

Cite this

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs : A multicenter cohort study and meta-analysis. / Haerian, Batoul Sadat; Baum, Larry; Kwan, Patrick; Tan, Hui Jan; Ali, Raymond Azman; Mohamed, Zahurin.

In: Pharmacogenomics, Vol. 14, No. 10, 2013, p. 1153-1166.

Research output: Contribution to journalArticle

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