Scale-up criteria and economic analysis for supercritical fluid extraction of Phyllanthus niruri

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Abstract

The purpose of this study is to determine the best scale-up criterion of the Supercritical Fluid Extraction (SFE) from Phyllanthus niruri. The modification of solubility determination for Sovová mass transfer model was successfully applied to the overall yield curves of SFE for the plant. Solvent to feed ratio (S/F) was found to be the best scale-up criterion for model verification and economic analysis because it will produce consistent yields at larger scale capacities. The economic analysis showed that this predicted process is profitable as it can achieve positive profit at the capacity of feed mass as low as 0.5 kg.

Original languageEnglish
Pages (from-to)14-22
Number of pages9
JournalChemical Engineering and Processing - Process Intensification
Volume139
DOIs
Publication statusPublished - 1 May 2019

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Supercritical fluids
Economic analysis
Profitability
Mass transfer
Solubility
Supercritical Fluid Chromatography

Keywords

  • Cost estimation
  • Mathematical modelling
  • Scale-up criteria
  • Supercritical fluid extraction

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Energy Engineering and Power Technology
  • Industrial and Manufacturing Engineering

Cite this

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title = "Scale-up criteria and economic analysis for supercritical fluid extraction of Phyllanthus niruri",
abstract = "The purpose of this study is to determine the best scale-up criterion of the Supercritical Fluid Extraction (SFE) from Phyllanthus niruri. The modification of solubility determination for Sovov{\'a} mass transfer model was successfully applied to the overall yield curves of SFE for the plant. Solvent to feed ratio (S/F) was found to be the best scale-up criterion for model verification and economic analysis because it will produce consistent yields at larger scale capacities. The economic analysis showed that this predicted process is profitable as it can achieve positive profit at the capacity of feed mass as low as 0.5 kg.",
keywords = "Cost estimation, Mathematical modelling, Scale-up criteria, Supercritical fluid extraction",
author = "Norsyamimi Hassim and Masturah Markom and Rosli, {Masli Irwan} and Shuhaida Harun",
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AU - Markom, Masturah

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AU - Harun, Shuhaida

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AB - The purpose of this study is to determine the best scale-up criterion of the Supercritical Fluid Extraction (SFE) from Phyllanthus niruri. The modification of solubility determination for Sovová mass transfer model was successfully applied to the overall yield curves of SFE for the plant. Solvent to feed ratio (S/F) was found to be the best scale-up criterion for model verification and economic analysis because it will produce consistent yields at larger scale capacities. The economic analysis showed that this predicted process is profitable as it can achieve positive profit at the capacity of feed mass as low as 0.5 kg.

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