Sarcoid myopathy mimicking polymyositis: A case report and pool analysis of the literature reviews

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Abstract

A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i.e., hypercalcemia, lymphadenopathy and subcutaneous nodules. Finally, a biopsy of the thigh and subcutaneous nodule revealed non-caseating granulomatous inflammation, consistent with sarcoidosis. He responded well to the corticosteroids, and finally, azathioprine was added as a steroid-sparing agent. Including our series, there are 103 cases of symptomatic muscle involvement in sarcoidosis patients published in the English literature to date. Further pool analysis of the cases will be reported in this review.

Original languageEnglish
Pages (from-to)800-806
Number of pages7
JournalActa Medica Iranica
Volume55
Issue number12
Publication statusPublished - 1 Jan 2017

Fingerprint

Polymyositis
Muscular Diseases
Sarcoidosis
Adrenal Cortex Hormones
Literature
Biopsy
Muscles
Myositis
Myalgia
Azathioprine
Hypercalcemia
Creatine Kinase
Thigh
Weight Loss
Steroids
Inflammation
Recurrence
Serum
Lymphadenopathy

Keywords

  • Granuloma
  • Myopathy
  • Sarcoidosis
  • Subcutaneous nodules

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Sarcoid myopathy mimicking polymyositis: A case report and pool analysis of the literature reviews",
abstract = "A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i.e., hypercalcemia, lymphadenopathy and subcutaneous nodules. Finally, a biopsy of the thigh and subcutaneous nodule revealed non-caseating granulomatous inflammation, consistent with sarcoidosis. He responded well to the corticosteroids, and finally, azathioprine was added as a steroid-sparing agent. Including our series, there are 103 cases of symptomatic muscle involvement in sarcoidosis patients published in the English literature to date. Further pool analysis of the cases will be reported in this review.",
keywords = "Granuloma, Myopathy, Sarcoidosis, Subcutaneous nodules",
author = "Shaharir, {Syahrul Sazliyana} and Adawiyah Jamil and Sumitro Kosasih and Fin, {Low Soo} and Radhika Sridharan and {Md Pauzi}, {Suria Hayati}",
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AU - Shaharir, Syahrul Sazliyana

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AU - Kosasih, Sumitro

AU - Fin, Low Soo

AU - Sridharan, Radhika

AU - Md Pauzi, Suria Hayati

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