Salphen metal complexes as tunable G-quadruplex binders and optical probes

Nurul Huda Abd Karim, Oscar Mendoza, Arun Shivalingam, Alexander J. Thompson, Sushobhan Ghosh, Marina K. Kuimova, Ramon Vilar

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A series of seven new metal complexes (metal = NiII, Cu II, PtII and VO2+) with substituted salphen ligands have been prepared and their duplex and G-quadruplex DNA affinities determined. The selectivity of the complexes towards a given DNA topology is dictated by several factors including geometry, overall charge and substitution pattern of the complex. We also show that the two platinum(II)-salphen complexes developed as part of this series are emissive. Confocal microscopy studies were carried out with these two complexes using four different cell lines (CHO, HeLa, U2OS and HepG2). These studies showed that the cell permeability and localization are different for the two probes and highly dependent on the cell line used.

Original languageEnglish
Pages (from-to)3355-3363
Number of pages9
JournalRSC Advances
Volume4
Issue number7
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Coordination Complexes
Metal complexes
Binders
DNA
Cells
Confocal microscopy
Platinum
Substitution reactions
Metals
Ligands
Topology
Geometry
salphen

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Abd Karim, N. H., Mendoza, O., Shivalingam, A., Thompson, A. J., Ghosh, S., Kuimova, M. K., & Vilar, R. (2014). Salphen metal complexes as tunable G-quadruplex binders and optical probes. RSC Advances, 4(7), 3355-3363. https://doi.org/10.1039/c3ra44793f

Salphen metal complexes as tunable G-quadruplex binders and optical probes. / Abd Karim, Nurul Huda; Mendoza, Oscar; Shivalingam, Arun; Thompson, Alexander J.; Ghosh, Sushobhan; Kuimova, Marina K.; Vilar, Ramon.

In: RSC Advances, Vol. 4, No. 7, 2014, p. 3355-3363.

Research output: Contribution to journalArticle

Abd Karim, NH, Mendoza, O, Shivalingam, A, Thompson, AJ, Ghosh, S, Kuimova, MK & Vilar, R 2014, 'Salphen metal complexes as tunable G-quadruplex binders and optical probes', RSC Advances, vol. 4, no. 7, pp. 3355-3363. https://doi.org/10.1039/c3ra44793f
Abd Karim NH, Mendoza O, Shivalingam A, Thompson AJ, Ghosh S, Kuimova MK et al. Salphen metal complexes as tunable G-quadruplex binders and optical probes. RSC Advances. 2014;4(7):3355-3363. https://doi.org/10.1039/c3ra44793f
Abd Karim, Nurul Huda ; Mendoza, Oscar ; Shivalingam, Arun ; Thompson, Alexander J. ; Ghosh, Sushobhan ; Kuimova, Marina K. ; Vilar, Ramon. / Salphen metal complexes as tunable G-quadruplex binders and optical probes. In: RSC Advances. 2014 ; Vol. 4, No. 7. pp. 3355-3363.
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